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The Promise of siRNA Nanomedicine for HIV Treatment

Society learned about the usefulness of mRNA during the COVID-19 pandemic when scientists and medical professionals leveraged its power to deliver a vaccine for the virus within a year.

21 Feb 2024

Unraveling Lenacapavir's Impact on the HIV Life Cycle

A new anti-retroviral medication for the treatment of human immunodeficiency virus (HIV) infections was licensed by the US Food and Drug Administration and the European Union just over a year ago.

14 Feb 2024

Understanding T Cell Responses to Tuberculosis Infection

Researchers find promising targets for a tuberculosis vaccine and medication by monitoring T cell activity.

7 Feb 2024

Unveiling HIV's Hidden Entry Point for Targeted Antibodies

As the HIV virus approaches a human cell to dock and potentially deliver its lethal genetic code, there is a remarkably brief moment during which a tiny portion of its surface undergoes a rapid opening, initiating the infection process.

5 Feb 2024

Scientists Create "Immunologically Silent" DNA Vaccine for Potent Virus Defense

Using a virus-like delivery particle made from DNA, researchers from MIT and the Ragon Institute of MGH, MIT, and Harvard have created a vaccine that can induce a strong antibody response against SARS-CoV-2.

31 Jan 2024

Scientists Reveal HIV's Secret Weapon for Invading Cell Nucleus

Around one million individuals worldwide become infected with HIV, the virus that causes AIDS, each year.

27 Jan 2024

Structural Insights Unmask Novel Adaptations and Functions of Human LINE-1 ORF2

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

20 Dec 2023

No Container, No Problem—Studying Self-Contained Spheres of Liquid Protein in Space Could Help Improve Medicine on Earth

How could studying liquid drops of protein solution in space help solve an Achilles’ heel in medicine production on Earth? Find out in the latest issue of Upward, the official magazine of the International Space Station (ISS) National Laboratory.

5 Dec 2023

Study Sheds Light on Factors Contributing to Low-Level Viremia in HIV Patients

Human immunodeficiency virus (HIV) works by entering specific immune cells and replicating inside them.

15 Nov 2023

Age-Related Hearing Loss Associated With Decrease of Cholesterol in the Inner Ear

Researchers led by María Eugenia Gomez-Casati, the Institute of Pharmacology, School of Medicine, University of Buenos Aires-CONICET; Mauricio Martin, the Institute of Medical Research Mercedes; and Martín Ferreyra, (INIMEC-CONICET-UNC), National University of Córdoba in Argentina report that age-related hearing loss is associated with a decrease of cholesterol in the inner ear.

25 Aug 2023

Supporting Informed Decisions on Malaria Biocontrol Interventions

Following World Mosquito Day, we spoke with Dr. Michael Santos from GeneConvene Global Collaborative about using genetically engineered mosquitoes to help tackle malaria and how the Collaborative supports informed decision-making regarding this potentially game-changing technique.

21 Aug 2023

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

Revealing the Function of Retrotransposons

A retrotransposon, a parasitic DNA sequence that borrows the cell’s own machinery to accomplish its objectives, has been discovered.

13 Jul 2023

EMBL-EBI Launches Pathogens Portal to Enhance Global Pathogen Surveillance

EMBL's European Bioinformatics Institute (EMBL-EBI) has launched the Pathogens Portal – an online platform that enables researchers, clinicians, and policymakers to access the most comprehensive collection of biomolecular data about pathogens.

7 Jul 2023

Using Pressure to Understand RNA Dynamics

Similar to how there are limitless secrets in space, there is still a lot to discover when looking at biomolecules, which are one trillion times smaller than a meter.

23 Jun 2023

Theta Supercomputer Used To Find Essential Factors That Control Structural Change of HIV Protease

Every disease has a protein basis. For some diseases, like HIV, changes in protein structure are critical for how the virus infects a person's cells.

20 Jun 2023

Microglial Cells Serve as a Stable Viral Reservoir for Latent HIV

Human immunodeficiency virus-1 (HIV) introduces a copy of its DNA into human immune cells as part of its life cycle. Some of these newly infected immune cells can subsequently enter an inactive, latent state for an extended length of time, which is known as HIV latency.

19 Jun 2023