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Stem Cells' Ability to Respond to Physical Forces Uncovered

A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to their environment, with implications for inflammatory bowel disease and colorectal cancer.

4 Dec 2024

Novel Fungal Commensal Shaping Mouse Immune Responses

Researchers from Weill Cornell Medicine have found a fungus in the stomach of mice that may provide a clue to the evolution of fungi in the gastrointestinal tract.

28 Nov 2024

New Role for the Golgi Apparatus in Cancer Immunotherapy

The Golgi apparatus modifies, sorts, and packages proteins to be sent to their final destinations, whether that is within or outside of the cell.

25 Nov 2024

Novel Approach to Lipid Nanoparticle Engineering

To enhance mRNA distribution, Penn engineers have created an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the COVID-19 vaccines and other cutting-edge treatments.

25 Nov 2024

Immunotherapy Advances: CAR T Cells Targeting GD2 Offer Hope for Glioma Patients

Findings suggest GD2-specific CAR T-cell therapy is a viable option for H3K27M-mutant gliomas, with significant tumor shrinkage and clinical benefits observed.

22 Nov 2024

Discover Photon etc.'s latest innovation: LightIR

Photon etc. announces the launch of its newest instrument, the LightIR system, designed for preclinical fluorescence imaging and clinical research.

From Photon etc. 31 Oct 2024

Encrypted Peptides Offer Hope Against Antibiotic-Resistant Infections

Researchers have discovered a new class of antimicrobial compounds called encrypted peptides, which could boost the immune system's toolkit to combat infection and counteract the growing problem of antibiotic-resistant bacteria.

29 Oct 2024

C. elegans Model Revolutionizes Search for Amyloid Inhibitors

An international team led by researchers at the University of Toronto has developed an efficient and robust system, using the C. elegans nematode, to screen for compounds that can stop the growth of amyloid proteins.

29 Oct 2024

EVQ-218: A Promising Candidate for Tackling Superbugs Without Triggering Antimicrobial Resistance

As the United Nations (UN) prepares to address the escalating threat of antimicrobial resistance, EVŌQ Nano is helping raise awareness through an educational infographic depicting a common trigger of antimicrobial resistance and highlighting EVQ-218's novel mechanism of action.

18 Oct 2024

Researchers Develop Innovative Human Macrophage Model for Disease Study

A human cell culture model of the lung's most important immune cells, alveolar macrophages, helped make a key finding that is prompting researchers to rethink the role of another immune protein in infectious disease.

15 Oct 2024

New Mouse Model Shows Superior Ability to Study Human Immune Response to Cancer

Immunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells – by using engineered antibodies – or by simply providing it with new cells, pre-equipped to search and destroy cancer. Either way, what is paramount is a deep understanding of how the immune system works and confronts tumors.

15 Oct 2024

Melanin May Act as a "Drug Sponge," Influencing Medication Effectiveness

Skin pigmentation may act as a "sponge" for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report in a perspective article published in the journal Human Genomics.

15 Oct 2024

Researchers Develop Highly Selective SARS-CoV-2 Mpro Inhibitors

New research from The Wistar Institute's Salvino lab -; led by professor Joseph Salvino, Ph.D. -; has identified a novel series of SARS-CoV-2 Mpro inhibitors that may lead to potential new COVID-19 treatments that, according to preclinical testing, effectively inhibits COVID-19 and synergizes with existing anti-COVID therapies.

9 Oct 2024

CAR-NKT Cells Show Promise in Overcoming Solid Tumor Barriers

Chimeric antigen receptor T-cell therapy (CAR-T) has shown significant promise in the treatment of blood malignancies in the fight against cancer.

8 Oct 2024

UNC Researchers Unveil CAR-NKT Therapy for Enhanced Antitumor Activity

In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.

8 Oct 2024

Two Alzheimer’s Genetic Risk Factors Trigger Harmful Inflammation in Females

Weill Cornell Medicine investigators have found that two genetic variants that confer high risk of Alzheimer's disease (AD) together trigger a harmful inflammatory response in the brain's immune cells, particularly in females, in a preclinical model.

1 Oct 2024

Innovative Approach Supercharges T Cells by Transferring Healthy Mitochondria

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion.

16 Sep 2024

Monoclonal Antibody SC27 Shows Broad Effectiveness Against SARS-CoV-2 Variants

A monoclonal antibody appears effective at neutralizing the numerous variants of SARS-CoV-2, as well as related viruses in animals that could pose a threat if they were to begin spreading in people.

10 Sep 2024

New Study Identifies Key Protein Influencing Longevity

It turns out that a particular gene has a great influence on longevity, a new study from the University of Copenhagen concludes. This may pave the way for new treatment.

5 Sep 2024

Microbiotica Secures Approvals to Begin Clinical Studies in EU and UK for New Microbiome Medicines

Microbiotica, a biopharma company developing a pipeline of oral precision microbiome medicines called live biotherapeutic products (LBPs), is pleased to announce that it has received regulatory approvals to initiate clinical studies for its first two programmes in advanced melanoma (MELODY-1) and ulcerative colitis (COMPOSER-1) in selected EU countries and the UK. Both studies are due to start shortly, with initial data readouts expected by the end of 2025.

30 Aug 2024