Ribosome News and Research

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Innovative Method Accelerates Discovery of New Drugs by Harnessing the Power of Ribosomes

A research team led by University of California, Irvine scientists has developed an innovative method for quickly and efficiently creating vast collections of chemical compounds used in drug discovery by harnessing the power of ribosomes, the molecules found in all cells that synthesize proteins and peptides.

24 Aug 2023

Scaffolding Protein Helps in the Creation of Biomolecular Condensate

Biomolecular condensates are loosely organized assemblies that carry out a variety of vital tasks inside all live cells. However, the mechanism by which proteins and other biomolecules combine to create these assemblies within cells is not fully known.

16 Aug 2023

Access of METAPs to Protein Factories is Controlled by NAC

On the basis of genetic blueprints, individual amino acids have been assembled into long amino acid chains, the proteins, in the protein factories of human cells, called the ribosomes.

23 Jun 2023

New Automated Machine Learning Tool to Design and Interpret Biological Sequences

The amount of data generated by scientists today is massive, thanks to the falling costs of sequencing technology and the increasing amount of available computing power.

22 Jun 2023

Reengineering the Cellular Synthetic Machinery to Produce Never-Before-Seen Polymers

Synthetic biologists have become increasingly creative in engineering yeast or bacteria to churn out useful chemicals -; from fuels to fabrics and drugs -; beyond the normal repertoire of microbes.

14 Jun 2023

Natural Peptide From Fruit Flies may Pave Way for New Antibiotics

Scientists at the University of Illinois Chicago have found that a peptide from fruit flies could lead to new antibiotics.

7 Jun 2023

New Delivery Mechanism Brings Messenger RNA to the Point of Need in Neurons

Brain cells manufacture proteins in every corner, including their long branches. Neurons missing this ability cause severe neurological disorders like disability and epilepsy.

5 Jun 2023

New Insight into the Dynamics of a Ribosomal Protein - RPL3L

A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

23 May 2023

Long-Ignored Antibiotic may Provide Much-Needed Protection Against Multi-Drug Resistant Bacteria

An old antibiotic may provide much-needed protection against multi-drug resistant bacterial infections, according to a new study publishing May 16th in the open access journal PLOS Biology by James Kirby of Harvard Medical School, US, and colleagues.

17 May 2023

Revealing an Unanticipated Mechanism for Chaperone-Mediated Ribosome Repair

Researchers have discovered that if oxidative stress destroys protein factories known as ribosomes, repair crews may go in to assist in repairing the damage so that production may restart rapidly.

26 Apr 2023

Two Molecular Mechanisms Combine to Make the Bacterium Extra Resistant

When the intestinal flora is killed by antibiotics, a species of ordinary gut bacteria that humans carry flourishes. Because the bacteria are naturally immune to many drugs, it poses complications, especially in healthcare settings.

18 Apr 2023

The protein synthesis mechanism in the Giardia parasite

Cryo-electron microscopy was employed by Uppsala University researchers to reveal information on the protein synthesis mechanism in the parasite Giardia intestinalis, which causes diarrhea. The new findings could help in the development of specific medicines to combat Giardia and other protozoan parasites.

20 Mar 2023

Using a programmable control switch to deliver therapeutic RNA molecules to target cells

Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene.

17 Mar 2023

Nanosatellite paves the way for developing RNA-based medicines

Researchers from Aarhus University and Berkeley Laboratory have designed RNA molecules, that folds into nanoscale rectangles, cylinders, and satellites, and have studied their 3D structure and dynamics with advanced nanotechnological methods.

28 Feb 2023

Learning about cellular proteins through “snapshots” of translation

Pep-tRNAs, nascent polypeptides inside the ribosome that are covalently connected to transfer RNA, are engaged in a variety of cell processes, including gene expression, according to advances in molecular biology.

1 Feb 2023

Novel insights into the elongation dynamics of eukaryotic cells

The proper functioning of numerous proteins generated in cells by ribosomes is essential for life. This diversified variety of proteins, called proteome, is sustained by the ribosomes’ vigorous translation elongation of amino acid sequences.

6 Jan 2023

An accurate overview of gene activity could provide targeted therapies

Normal gene activity in the afflicted cells is changed during pathological events. Therefore, obtaining a precise picture of gene activity could hold the key to the creation of new, targeted therapies.

18 Oct 2022

The ability of cells to adjust their growth to changing environmental conditions

Growth is a fundamental element of all life on this planet, whether it be a mammal, a single-celled organism, a plankton, or a sequoia.

18 Oct 2022

Therapeutic mRNAs do not significantly impact translational fidelity

Synthetic mRNA therapeutics for the treatment and prevention of disease has attracted a lot of interest due to the exceptional efficacy of mRNA vaccinations against SARS-CoV-2.

30 Aug 2022

Researchers explore how tRNAs evolve in protein synthesis

In the process of protein synthesis, a peptide bond is formed between two amino acids that are bound to two different transfer RNAs (tRNAs). Researchers have long been perplexed as to how these tRNAs evolved to be so near to one another on the ribosome.

From Tokyo University of Science 22 Apr 2022