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Columbia researchers develop new blood test to measure the pace of biological aging

Researchers at Columbia University Mailman School of Public Health have developed a new blood test to measure the pace of biological aging. Based on an analysis of chemical tags on the DNA contained in white blood cells, called DNA methylation marks, the new test is named DunedinPACE, after the Dunedin Birth Cohort used to develop it.

19 Jan 2022

Immune cells in arteries can sniff out their surroundings and cause inflammation

An artery is not like a nose. Or is it? Scientists at La Jolla Institute for Immunology (LJI) have discovered that immune cells in arteries can "sniff" out their surroundings and cause inflammation.

17 Jan 2022

Daily consumption of more olive oil linked to lower mortality risk

Consuming more than 7 grams (>1/2 tablespoon) of olive oil per day is associated with lower risk of cardiovascular disease mortality, cancer mortality, neurodegenerative disease mortality and respiratory disease mortality, according to a study publishing today in the Journal of the American College of Cardiology.

17 Jan 2022

Risk linked to coronary arteriosclerosis may be explained by changes in gene networks

Up to 60 percent of the risk associated with coronary arteriosclerosis may be explained by changes in the activity of hundreds of genes working together in networks across several organs in the body.

17 Jan 2022

Researchers identify new potential drug target that may block SARS-CoV-2 infection

In the quest for new treatments for COVID-19, a team led by researchers at UC San Francisco has identified a new potential drug target that may block infection by SARS-CoV-2. The protein, called BRD2, regulates the ACE2 receptor, which the novel coronavirus relies on to gain entry to its host's cells.

17 Jan 2022

Changes in the activity of gene networks may explain arteriosclerosis risk

Up to 60 percent of the risk associated with coronary arteriosclerosis may be explained by changes in the activity of hundreds of genes working together in networks across several organs in the body.

13 Jan 2022

Scientists examine key mechanisms underlying genomic imprinting

Hereditary diseases, along with cancers and cardiovascular diseases, may be linked to genomic imprinting.

13 Jan 2022

Targeting the inflamed intestinal wall may be a novel way to prevent inflammation in HIV patients

New UCLA-led research in mice suggests that adding a certain type of tomato concentrate to the diet can reduce the intestinal inflammation that is associated with HIV. Left untreated, intestinal inflammation can accelerate arterial disease, which in turn can lead to heart attack and stroke.

13 Jan 2022

Study analyzes the impact of T cells from common cold coronaviruses against SARS-CoV-2 exposure

A new study has illustrated that people having higher levels of T cells from common cold coronaviruses are not likely to get infected with SARS-CoV-2.

13 Jan 2022

Increasing the expression of a gene slows Alzheimer’s progression in mice

According to a recent research, enhancing the expression of one gene in cells that help the brain’s neurons, shields neurons in mouse models of Alzheimer’s disease.

13 Jan 2022

Scientists discover new Senp5S protein with crucial role in brain development

Understanding how the brain develops is crucial to formulating treatments and management protocols for a variety of developmental disorders, as well as degenerative neurological diseases. Right from the embryonic stage, brain development is facilitated by the differentiation of neurons (brain cells).

12 Jan 2022

Research explains how E4 peptide exerts antifibrotic effect and what makes it so effective

A research team at the Medical University of South Carolina led by Carol Feghali-Bostwick, Ph.D., reports in the Journal of Clinical Investigation Insight that the E4 peptide reverses fibrosis, or scarring, in human and mouse tissues by activating an antifibrotic pathway that is common to all organ systems.

11 Jan 2022

Scientists develop molecules for myocardial PET and fluorescence bimodal imaging

Heart disease continues to be a leading cause of mortality and morbidity across the globe. Positron emission tomography (PET) has slowly become a remarkable technology of a non-invasive technique for accurately diagnosing cardiac diseases.

11 Jan 2022

Versatile method produces massive numbers of authentic human heart muscle cells

Scientists at the Leiden University Medical Centre (LUMC) successfully cultured human heart muscle cells on a large scale.

11 Jan 2022

CAR T cells produced in vivo using modified mRNA treat cardiac injury

A new study by researchers from the University of Pennsylvania shows that experimental immunotherapy can temporarily reprogram the immune cells of patients.

10 Jan 2022

Research shows how bacteria silence potentially deadly genes

Humans are all made of collections of cells, where each cell contains instructions in the DNA to become another cell.

7 Jan 2022

In vivo generation of engineered CAR T cells to treat heart injury

A novel immunotherapy strategy using in vivo generation of transient engineered chimeric antigen receptor (CAR) T cells, through the delivery of modified mRNA, can reduce fibrosis and restore cardiac function in a mouse model of heart failure, researchers report.

7 Jan 2022

Research highlights opportunities to expand the manufacture of stem cells in space

The secret to producing large batches of stem cells more efficiently may lie in the near-zero gravity conditions of space. Scientists at Cedars-Sinai have found that microgravity has the potential to contribute to life-saving advances on Earth by facilitating the rapid mass production of stem cells.

3 Jan 2022

Study reveals a tug-of-war between genes inherited from the father and the mother

Cambridge scientists have identified a key signal that the fetus uses to control its supply of nutrients from the placenta, revealing a tug-of-war between genes inherited from the father and from the mother. The study, carried out in mice, could help explain why some babies grow poorly in the womb.

28 Dec 2021

Blocking function of blood-clotting protein prevents bone loss from gum disease in mice

Blocking function of a blood-clotting protein prevented bone loss from periodontal (gum) disease in mice, according to research led by scientists at the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health.

24 Dec 2021

Heart News and Research

Columbia researchers develop new blood test to measure the pace of biological aging

Immune cells in arteries can sniff out their surroundings and cause inflammation

Daily consumption of more olive oil linked to lower mortality risk

Risk linked to coronary arteriosclerosis may be explained by changes in gene networks

Researchers identify new potential drug target that may block SARS-CoV-2 infection

Changes in the activity of gene networks may explain arteriosclerosis risk

Scientists examine key mechanisms underlying genomic imprinting

Targeting the inflamed intestinal wall may be a novel way to prevent inflammation in HIV patients

Study analyzes the impact of T cells from common cold coronaviruses against SARS-CoV-2 exposure

Increasing the expression of a gene slows Alzheimer’s progression in mice

Scientists discover new Senp5S protein with crucial role in brain development

Research explains how E4 peptide exerts antifibrotic effect and what makes it so effective

Scientists develop molecules for myocardial PET and fluorescence bimodal imaging

Versatile method produces massive numbers of authentic human heart muscle cells

CAR T cells produced in vivo using modified mRNA treat cardiac injury

Research shows how bacteria silence potentially deadly genes

In vivo generation of engineered CAR T cells to treat heart injury

Research highlights opportunities to expand the manufacture of stem cells in space

Study reveals a tug-of-war between genes inherited from the father and the mother

Blocking function of blood-clotting protein prevents bone loss from gum disease in mice

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