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Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

A research team has used a novel method that could help resolve the issue of unnecessary genetic changes encountered in the CRISPR-Cas9 technique.

7 Dec 2020

Gene therapy and medication can provide certain beneficial effects of physical exercise

Jose Bianco Moreira from NTNU is now convinced that gene therapy can be used to achieve the positive health benefits of physical exercise.

7 Dec 2020

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

According to a new study, a novel T cell genetically engineered by scientists from The University of Arizona Health Sciences can target and attack pathogenic T cells that are responsible for causing Type 1 diabetes. These latest findings may result in new immunotherapy therapies.

7 Dec 2020

Study determines 3D structure of molecular machine involved in placement of key proteins

Within a single cell, more than a quarter of all proteins are found in the membrane, in which they carry out crucial functions.

7 Dec 2020

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting.

7 Dec 2020

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma, according to findings from a multi-institutional phase I study being presented by Alfred L. Garfall, MD, an assistant professor of Medicine in the division of Hematology-Oncology in the Perelman School of Medicine at the University of Pennsylvania, at the annual American Society of Hematology & Exposition Meeting on Dec. 5 (abstract #180).

7 Dec 2020

Scientists develop effective solution to improve direct methanol fuel cell

Because of the many environmental problems caused by the use of fossil fuels, many scientists worldwide are focused on finding efficient alternatives.

7 Dec 2020

Biochemist discovers hidden cellular machinery essential for higher-order life

In his first year of graduate school, Rice University biochemist Zachary Wright discovered something hidden inside a common piece of cellular machinery that's essential for all higher order life from yeast to humans.

7 Dec 2020

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes.

7 Dec 2020

CRISPR-based test for COVID-19 provides quick, accurate results

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

7 Dec 2020

Gasdermin E triggers pyroptosis and involved in pathogen-induced coral death

Pyroptosis is a highly inflammatory form of programmed necrotic cell death that acts as a defense mechanism against the infection of bacterial and viral pathogens. Pyroptosis is executed by gasdermin, a family of pore-forming proteins.

7 Dec 2020

Study shows fluorescent protein molecules act as tiny antennas with optical properties

Scientists have revealed that fluorescent protein molecules serve as antennas with optical characteristics according to their spatial orientation.

4 Dec 2020

Researchers use super-resolution microscopy to study bacterial infection mechanisms

Expansion microscopy, abbreviated as ExM, allows scientists to image cells and their components with a spatial resolution down to 200 nm.

4 Dec 2020

Study sheds new light on potential risk factors for preterm birth

A recent study has detected new genetic markers linked to the duration of gestation. These findings shed new light on the possible risk factors for preterm birth.

4 Dec 2020

Study may lead to novel organisms that are more efficient at converting plants into biofuels

A new study reveals how bacteria control the chemicals produced from consuming 'food.' The insight could lead to organisms that are more efficient at converting plants into biofuels.

4 Dec 2020

Research reveals fundamental insights into the causes of severe birth defects

Research by Kai Jiao, M.D., Ph.D., and colleagues at the University of Alabama at Birmingham and in Germany has yielded fundamental insights into the causes of severe birth defects known as CHARGE syndrome cases. These congenital birth defects include severe and life-threatening heart malformations.

3 Dec 2020

Drug meant for bacterial infections can combat weight gain

A drug originally developed to treat bacterial infections has proved capable of boosting the metabolism and attenuating the weight gain induced by a fatty diet in tests with mice. The study was conducted at the University of Campinas (UNICAMP) with FAPESP's support, and the findings have just been published in the journal Science Advances.

3 Dec 2020

Specific immune mechanism in COVID-19 patients triggers inflammatory process

Researchers at the University of São Paulo (USP) in Brazil have demonstrated for the first time that in COVID-19 patients an immune mechanism known as the inflammasome participates in activation of the inflammatory process that can damage several organs and even lead to death.

3 Dec 2020

Researchers determine role of NLRP1 protein in detecting the common cold virus

The role of a protein in detecting the common cold virus and kickstarting an immune response to fight infection has been uncovered by a team of scientists from Nanyang Technological University, Singapore (NTU Singapore), the Agency for Science, Technology and Research (A*STAR) and the National University of Singapore.

From Nanyang Technological University Singapore (NTU Singapore) 3 Dec 2020

Cell News and Research

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

Gene therapy and medication can provide certain beneficial effects of physical exercise

Researchers target pathogenic T cells that could lead to new immunotherapy treatments

Study determines 3D structure of molecular machine involved in placement of key proteins

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

Scientists develop effective solution to improve direct methanol fuel cell

Biochemist discovers hidden cellular machinery essential for higher-order life

Scientists reveal health benefits of clonal hematopoiesis in allogeneic transplants

CRISPR-based test for COVID-19 provides quick, accurate results

Gasdermin E triggers pyroptosis and involved in pathogen-induced coral death

Study shows fluorescent protein molecules act as tiny antennas with optical properties

Researchers use super-resolution microscopy to study bacterial infection mechanisms

Study sheds new light on potential risk factors for preterm birth

Study may lead to novel organisms that are more efficient at converting plants into biofuels

Research reveals fundamental insights into the causes of severe birth defects

Drug meant for bacterial infections can combat weight gain

Specific immune mechanism in COVID-19 patients triggers inflammatory process

Researchers determine role of NLRP1 protein in detecting the common cold virus

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