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New classification method divides breast cancers into 12 distinct biological groups

Researchers at UNC Lineberger Comprehensive Cancer Center have taken a major step forward in melding two key methods for studying breast cancer: one by genetic analysis and the second by looking at the architecture of cells, or their pathology.

9 Dec 2021

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

A next-generation technology that allows the study of protein expression at the single-cell level and the location of the cells within the tumor microenvironment (TME) was feasible and provided information on the benefit of adding the immune checkpoint inhibitor atezolizumab (Tecentriq) to chemotherapy as neoadjuvant treatment for patients with early high-risk and locally advanced triple negative breast cancer (TNBC), according to results presented at the San Antonio Breast Cancer Symposium, held December 7-10, 2021.

8 Dec 2021

New strategy to improve the therapeutic efficacy of liver cancer immunotherapy

In recent years, tumor immunotherapy has emerged as a highly promising and much-touted oncological approach.

8 Dec 2021

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.

2 Dec 2021

Study identifies genes that protect ovarian cancer from antitumor immunity

Immunotherapies are exhibiting better clinical benefit in the treatment of numerous cancers, particularly when used along with chemotherapy.

2 Dec 2021

Study finds amphipathic peptide that safely opens endosomal membrane

The cell plasma membrane and the derived endosomal membranes are both greasy barriers that prevent the inflow of water-soluble macromolecules like nucleic acids and proteins into cells.

2 Dec 2021

Introducing the PhysioMimix™ OOC Multi-Organ Microphysiological System

CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS.

From CN Bio Innovations Limited 1 Dec 2021

Researchers show that tumor cells contribute differently to the formation of metastases

A type of cell transformation known as EMT enables cancer cells to break away from the tumor and form metastases elsewhere.

30 Nov 2021

Treatment with common allergy medication linked to improved immunotherapy response

New research from The University of Texas MD Anderson Cancer Center found that treatment with antihistamines, a commonly used allergy medication, was associated with improved responses to immune checkpoint inhibitors.

29 Nov 2021

Novel therapeutic approach forces cancer cells to dormancy, prevents metastasis

A novel therapeutic approach inhibits the growth of metastatic tumors in mice by coercing cancer cells into a dormant state—where they cannot proliferate.

25 Nov 2021

Regulating the activity of a protein enhances health span, says research

Scientists from KAIST put forth novel insights for enhancing the health span by controlling a protein’s activity.

25 Nov 2021

Study identifies key proteins that damage skin cells in psoriasis

Psoriasis is an autoimmune disease that is characterized by patches of red, inflamed skin and painful, scaly rashes.

25 Nov 2021

UD biochemist explores how mRNA eraser enzymes work in our cells

University of Delaware biochemist Jeff Mugridge is trying to figure out how so-called mRNA eraser enzymes work in our cells, why those erasers can sometimes misbehave and lead to cancer, and how science can pave the way for possible solutions to this problem.

25 Nov 2021

MIT researchers identify a way to indirectly activate T cells to fight tumors

Under the right circumstances, the body's T cells can detect and destroy cancer cells. However, in most cancer patients, T cells become disarmed once they enter the environment surrounding a tumor.

22 Nov 2021

Cancer cells disarm immune cells by hijacking mitochondria, says research

Researchers utilized the power of nanotechnology to identify a novel means that cancer cells use to disarm their would-be cellular attackers.

19 Nov 2021

New group of molecules that have an antibacterial effect identified

Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria.

18 Nov 2021

Genomic changes in advanced tumors reveal interactions with treatment

A novel way to look at cancer treatment resistance offers the possibility for identifying genetic mechanisms involved and alternative treatment approaches.

17 Nov 2021

New technique anticipated to deliver personalized immunotherapies for cancer

Recent research led to a very effective technique to create many immune cells particularly engineered to identify neoantigens.

17 Nov 2021

Researchers test a neoantigen-specific transgenic immune cell therapy for malignant gliomas

Doctors and scientists from the German Cancer Research Center (DKFZ) and from Heidelberg University's Medical Faculty Mannheim have successfully tested a neoantigen-specific transgenic immune cell therapy for malignant brain tumors for the first time using an experimental model in mice.

16 Nov 2021

Study shows how a common gene mutation robs people of natural cancer protection

Scientists from the University of Virginia School of Medicine have identified how a common gene mutation deprives people of natural protection against cancer.

15 Nov 2021

Tumor News and Research

New classification method divides breast cancers into 12 distinct biological groups

Single-cell spatial analysis may provide information about neoadjuvant therapy for triple-negative breast cancer

New strategy to improve the therapeutic efficacy of liver cancer immunotherapy

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

Study identifies genes that protect ovarian cancer from antitumor immunity

Study finds amphipathic peptide that safely opens endosomal membrane

Introducing the PhysioMimix™ OOC Multi-Organ Microphysiological System

Researchers show that tumor cells contribute differently to the formation of metastases

Treatment with common allergy medication linked to improved immunotherapy response

Novel therapeutic approach forces cancer cells to dormancy, prevents metastasis

Regulating the activity of a protein enhances health span, says research

Study identifies key proteins that damage skin cells in psoriasis

UD biochemist explores how mRNA eraser enzymes work in our cells

MIT researchers identify a way to indirectly activate T cells to fight tumors

Cancer cells disarm immune cells by hijacking mitochondria, says research

New group of molecules that have an antibacterial effect identified

Genomic changes in advanced tumors reveal interactions with treatment

New technique anticipated to deliver personalized immunotherapies for cancer

Researchers test a neoantigen-specific transgenic immune cell therapy for malignant gliomas

Study shows how a common gene mutation robs people of natural cancer protection

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