CRISPR News and Research

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In the late 1980s and mid-1990s, genomes of diverse lineages of bacteria and archaea (the latter representing a domain of single-celled prokaryotic microorganisms) revealed clusters of regularly interspaced short palindromic repeats, known today under the abbreviation CRISPR. Later it was found that these repeat sequences (previously considered disparate) share a common set of features.

Mouse model helps track organism’s development, cell by cell

Scientists at the Stem Cell Research program at Boston Children's Hospital and Dana-Farber Cancer Institute/Harvard Medical School have devised a mouse model that lets researchers track every cell in the body, from the embryonic stage until adulthood.

15 May 2020

Biosynthetic capacity allows cancer stem cells to contribute to tumor growth

Tumors are not a consistent cluster of cells. In fact, colon cancers carry differentiated-like cells, just like the functional cells of the intestinal wall and pluripotent cells—the supposed tumor stem cells.

13 May 2020

Single-cell gene expression studies can shed more light on disrupted genes

Scientists can gain a better understanding of the cellular roles of the disrupted gene by disturbing the expression of a specific gene and tracking how this change has an impact on the expression of other types of genes.

13 May 2020

Entos and Precision NanoSystems to develop vaccines and therapeutics using NanoAssemblr GMP System

Entos Pharmaceuticals, a healthcare biotechnology company developing next generation nucleic acid medicines with their Fusogenix delivery platform announced today a partnership with Precision NanoSystems, Inc., (PNI), a global leader in enabling transformative nanomedicines, to produce clinical grade vaccines and therapeutics using PNI's NanoAssemblr GMP System.

7 May 2020

Study shows how DNA mimic protein helps phages to attack their victims

A research team from the Severinov Laboratory at Skoltech, together with their collaborators from Israel and Switzerland, has analyzed a bacterial BREX defense mechanism that was poorly studied to date.

29 Apr 2020

A Step Toward A Better Way To Make Gene Therapies To Attack Cancer, Genetic Disorders

A UCLA-led research team today reports that it has developed a new method for delivering DNA into stem cells and immune cells safely, rapidly and economically.

28 Apr 2020

Researchers use CRISPR/Cas9 to search for Alzheimer's-related genes

Experts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "molecular scissors" of CRISPR/Cas9 to search for new genes related to the neurodegenerative disease.

22 Apr 2020

Researchers use genome-wide CRISPR technology to identify leukemia's weakness

A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse.

From UC San Diego 21 Apr 2020

Novel protein facilitates a critical event in mammalian fertilization

Fertilization is a fundamental process in sexual reproduction when the combination of male and female gametes blends genetic material to create a new unique individual. Now, researchers from Japan have identified a new factor that may help orchestrate this vitally complex life event.

From Osaka University 17 Apr 2020

Study clears potential obstacle to using gene drive strategy to control mosquitoes

New research from entomologists at UC Davis clears a potential obstacle to using CRISPR-Cas9 "gene drive" technology to control mosquito-borne diseases such as malaria, dengue fever, yellow fever and Zika.

From The University of California, Davis 17 Apr 2020

Diagnostics, Meet CRISPR

The simplicity of urine sampling has been combined with the excellent sensing abilities of CRISPR to improve diagnostic testing for kidney transplant patients.

17 Apr 2020

How human cells recognize undesirable guests

Until now, the immune sensor TLR8 has remained in the shadows of science. A research team led by the University of Bonn has now discovered how this sensor plays an important role in defending human cells against intruders.

15 Apr 2020

New genetic techniques expand microbial research

A team of international scientists has developed a suite of more than 200 new genetic techniques for using marine microbes to investigate a host of questions in biology.

7 Apr 2020

Study examines molecular causes of spondylocostal dysostosis

Researchers from EMBL Barcelona’s Ebisuya group collaborated with colleagues from RIKEN, Kyoto University, and Meijo Hospital in Nagoya, Japan, to investigate oscillating patterns of gene expression, coordinated across time and space within a tissue grown in vitro.

7 Apr 2020

Primitive bacterial parasites were first to use CRISPR to combat against one another

Humans are not the first to leverage the benefits of CRISPR. Pioneering research at the University of Copenhagen (UCPH) has enabled redefining what CRISPR is.

25 Mar 2020

New CRISPR technology targets thousands of genes

Thanks to CRISPR-based genetic screens, researchers were able to detect genes that play a major role in lung cancer metastasis, cancer immunotherapy, sickle-cell anemia, and a host of other medical disorders.

18 Mar 2020

Study explains “dark” portion of human genome implicated in various disorders

A “dark” part of the human genome has puzzled researchers for many years, similar to an enigmatic dark matter that accounts for 85% of the universe.

12 Mar 2020

Study reports first-ever application of CRISPR-Cas12b system in plant genome engineering

In a study reported recently in Nature Plants, Yiping Qi—assistant professor of Plant Science at the University of Maryland—has found a new CRISPR genome engineering system, called CRISPR-Cas12b, that is viable in plants for the first time.

10 Mar 2020

Study explores the impact of solute carriers on the activity and potency of cytotoxic drugs

At the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, scientists have investigated how solute carriers (SLCs)—a large class of membrane transport proteins—affect the activity and potency of cytotoxic drugs, for example, those used to treat leukemia and other cancers.

10 Mar 2020

New chromosome-level detectors developed to monitor cellular activity

For researchers investigating the regulatory processes in cells that are vital to all life, an innovative system that amplifies gene expression signals could be a turning point.

10 Mar 2020