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Fastest-evolved regions of the human genome diverged rapidly after split from chimpanzee ancestor

A team of Duke researchers has identified a group of human DNA sequences driving changes in brain development, digestion and immunity that seem to have evolved rapidly after our family line split from that of the chimpanzees, but before we split with the Neanderthals.

24 Nov 2022

Revealing the functional significance of DDX41 in great detail

The DDX41 gene encodes the nuclear enzyme DEAD-box-type RNA helicase. Hematopoietic malignancies are caused by DDX41 mutations. However, the mechanism behind the development of this malignancy remains unknown.

21 Nov 2022

Rapid fluctuations in electrical activity within breast cancer cells identified

Recent research has discovered that the membranes of breast cancer cells have varying voltages, revealing information regarding their growth and spread.

15 Nov 2022

Novel method tags proteins from specific cancer cells

Biomarkers are extremely useful tools that enable doctors to research biology and disease by, for instance, diagnosing a disease from a blood or tissue sample, predicting whether a treatment will be beneficial in a person, or determining how much of a drug is entering diseased cells.

28 Oct 2022

Innovative method opens myriad new avenues for understanding the biology behind COVID-19

A highly innovative method using the latest technology has generated a comprehensive list of SARS-CoV-2 viral and human proteins that interact with each other, with one such interaction showing the virus directly influencing proteins that regulate the human immune system.

18 Oct 2022

Characterizing the transcription profile of microglia in a mouse model

Researchers from Tohoku University have now shown that the consolidation and extinction of contextual fear conditioning alter the microglial genes connected to the synapse—structures that permit neurons to communicate with one another.

13 Sep 2022

Researchers create novel human cell line to explore blinding eye disorders

Researchers at the LSU Health New Orleans Neuroscience Center of Excellence have created a novel, experimental human cell line from retinal pigment epithelial cells, under the supervision of Boyd Professor Nicolas Bazan, MD, PhD.

14 Jul 2022

Scientists link the function of specific domain of proteins to a cancer trigger in humans

Researchers at the Department of Energy's Oak Ridge National Laboratory have definitively linked the function of a specific domain of proteins important in plant-microbe biology to a cancer trigger in humans, knowledge that had eluded scientists for decades.

6 Jul 2022

Researchers discover effective therapy for pediatric T-acute leukemia

The most frequent type of malignancy in kids is acute lymphoblastic leukemia (ALL).

27 Jun 2022

Drugs used for myelodysplastic syndrome could potentially activate a sleeping oncogene

Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.

From National University of Singapore (NUS) 27 May 2022

National DNA Day 2022: an interview with Professor Matthew Cobb

To celebrate National DNA Day 2022, we spoke to science communicator Professor Matthew Cobb.

From The University of Manchester 25 Apr 2022

High performance microplates for enhanced cell growth and survival

The Sero Krystal™ PDL range of coated microplates from Porvair Sciences set a new benchmark for reproducible cell culture even with challenging cell types.

From Porvair Sciences Limited 20 Apr 2022

Scientists produce the first complete, gapless sequence of a human genome

Two decades after the Human Genome Project delivered the first preliminary human genome sequence, researchers have published the first full, gapless sequence of a human genome.

From National Human Genome Research Institute (NHGRI) 4 Apr 2022

Researchers discover a novel pathway for DNA transfer in the tumor microenvironment

Scientists from the University of Notre Dame have found a new way for tumor cells to transmit genetic material to other cells in their microenvironment, allowing cancer to spread.

1 Apr 2022

Orbit Discovery and WuXi AppTec sign agreement to access peptide discovery and optimisation technologies

Orbit Discovery is pleased to announce the commencement of a partnership with WuXi AppTec, a leading global provider of R&D and manufacturing services.

8 Mar 2022

Simple lab model helps investigate the properties of muscle cells from sIBM patients

A team of researchers at Tohoku University have developed a simple lab-based system for growing human muscle cells that are capable of vigorously contracting.

3 Mar 2022

Researchers identify a sound-sensitive mammalian protein

Salk researchers have programmed mammalian cells to be stimulated with ultrasound.

14 Feb 2022

Cell culture environments are unstable and drive reproducibility crisis

Culture environments of different cell types growing in culture vessels or Petri dishes vary significantly from each other and from conditions in the living body, potentially driving the "reproducibility crisis" in biomedical research, according to a team of KAUST bioscientists.

9 Feb 2022

Label-free device enables in-situ tracking of cell development and maturation

The biological intracellular microenvironment is diverse, consisting of several cell compartments and intracellular components.

20 Jan 2022

NRL scientists apply new methods to analyze cell behavior

Naval Research Laboratory researchers in the Chemistry Division apply their knowledge of biology in conjunction with materials to improve understanding of how cells and tissues organize and apply new methods to affect cell communication.

From United States Naval Research Laboratory 6 Jan 2022