DNA Damage News and Research

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Researchers Identify Key Protein in Maintaining Two Organelles, Thereby Preventing Cellular Aging

Healthy organelles are essential to the operation of the cell, just as healthy organs are essential to human well-being.

2 Jan 2024

Sirtuin 6 Boosts DNA Repair in Aging Cartilage Cells

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

20 Dec 2023

Tokyo Metropolitan University Decodes DNA Repair Mechanisms

Tokyo Metropolitan University researchers have uncovered crucial aspects of the DNA repair mechanism within human bodies.

16 Nov 2023

Nucleotide Metabolite Controls DNA Repair and Cancer Sensitivity

Scientists have unraveled the mechanism by which a particular metabolite regulates DNA repair activity and the susceptibility of tissues to cancer treatment.

3 Nov 2023

Targeting eIF4A with Zotatifin: A Promising Strategy for TNBC Treatment

Enhancing treatment options for triple-negative breast cancer (TNBC), a highly aggressive tumor with a grim prognosis and limited therapeutic possibilities has proven to be a formidable challenge.

31 Oct 2023

New Insights Into the Role of Autophagy in Yeast Aging

Aging is an inevitable process that impacts all cell types, making yeast cells a common choice as a model organism in aging research.

26 Oct 2023

Researchers Develop Drug Targeting lncRNA TUG1 to Control Brain Tumor Growth in Mice

A new study has unraveled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.

13 Oct 2023

Scientists Explain How Enhancer Reprogramming Promotes Tumor Cell Growth

Cancer cells can boost tumor development by hijacking enhancer DNA, which is typically utilized when tissues and organs form, according to researchers at the University of Toronto (U of T).

29 Sep 2023

Unraveling the Link Between Chromosomal Instability and Cancer Spread

Chromosomal instability is a phenomenon marked by rapid alterations in the count and configuration of chromosomes during cell division. This occurrence is prevalent in solid tumors and is closely associated with the aggressive dissemination of cancer, known as metastasis.

27 Sep 2023

Newly Discovered Fungus Helps Destroy a Harmful Food Toxin

Patulin is a harmful mycotoxin produced by fungi typically found in damaged fruits, including apples, pears, and grapes.

1 Sep 2023

Elephants may Hold Secrets to Long Life

Indiana University researcher Daniella Chusyd is studying human aging in an unlikely way: through elephants.

7 Aug 2023

Discovering Age and Sex-Specific Obesity Genes in the Genome

Right from impacting how the human body stores fat to how the brain regulates appetite, hundreds of genes, together with environmental factors, jointly identify weight and body size.

3 Aug 2023

Analyzing DNA Damage-Induced NF-κB Targeted by Novel Small Molecule Inhibitors

Chemotherapy and radiotherapy aim to destroy cancer cells by inducing DNA double-strand breaks – damage that, once inflicted, usually causes the cells to die. But damage to a cell's genetic material also activates a signaling pathway called IKK/NF-κB that helps prevent cell death, thus limiting the success of these treatments in patients.

28 Jul 2023

Cells with “Jumping Genes” Self-Destruct in the Early Stages of Development

A previously unknown type of cell that self-destructs within days of forming as part of a quality control procedure to protect the growing fetus has been found by researchers studying gene activity data of the early human embryo.

21 Jun 2023

Scientists Discover New Embryonic Cell Type that Self-Destructs to Protect the Developing Embryo

Scientists studying gene activity data of the early human embryo have discovered an overlooked type of cell which self-destructs within days of forming, as part of a quality control process to protect the developing foetus.

21 Jun 2023

Heat-Damaged DNA in Food Linked to Possible Genetic Risks

Researchers have newly discovered a surprising and potentially significant reason why eating foods frequently cooked at high temperatures, such as red meat and deep-fried fare, elevates cancer risk. The alleged culprit: DNA within the food that's been damaged by the cooking process.

14 Jun 2023

Study Provides Evidence for Involvement of p53/p16/RB-E2F-DREAM Repressional Targets in Cellular Senescence

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

14 Jun 2023

Unraveling the Link Between Environmental Toxins and Lymphoma in Dogs

Lymphoma is a common cancer in dogs, but unlike human studies, which have associated the disease with environmental toxins, little is known about how it originates in dogs.

2 Jun 2023

Antioxidant Enzymes Relocate to the Nucleus in Response to DNA Damage

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

2 Jun 2023

Novel Map Depicts the Human Body's Highly Complicated System for Repairing DNA Damage

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage -; a cause and consequence of many diseases.

23 May 2023