Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Peptidomimetics Unlock New Potential in Drug Discovery

Collaborating with the Universities of Bristol and Leeds, researchers at the University of Birmingham have effectively demonstrated a method for modifying peptides to transform them into potentially useful tools for drug discovery and disease diagnosis

10 Jun 2024

Brain Organoids Emerge as Powerful Tool for Drug Discovery in Mitochondrial Disease

The use of brain organoids in screening for drugs against mitochondrial diseases, which have hitherto presented challenges in treatment.

4 Jun 2024

Secarna and Orbit Discovery Partner to Develop Next-Generation Targeted ASO Therapeutics

Secarna Pharmaceuticals GmbH & Co. KG (Secarna), a leading independent European antisense drug discovery and development company, and Orbit Discovery Ltd. (Orbit), a leader in the discovery of therapeutic peptide hits, today announced that they have entered into a collaboration to discover and develop peptide-conjugated targeted antisense oligonucleotide (ASO) therapeutics.

3 Jun 2024

Integrative genomic study identifies two new potential drug targets in Mycobacterium tuberculosis

Researchers used existing whole genome sequences of M. tuberculosis and conducted a pangenomic analysis to identify potential drug targets.

28 May 2024

Mapping Neurodevelopmental Disease with High-Throughput In Vivo Perturb-seq

The brain is often referred to as a "black box"-;one that's difficult to peer inside and determine what's happening at any given moment.

21 May 2024

Sartorius Expands Collaboration with NVIDIA to Advance AI-Powered Drug Discovery

The life science group Sartorius is expanding its multidisciplinary collaboration with NVIDIA to help enable the development of new and better therapies, combining Sartorius’ in-depth knowledge of life sciences and bioprocessing with NVIDIA’s AI-powered computing platforms and software.

20 May 2024

Syntekabio to Unveil Novel Biologics Platform at 20th Annual PEGS Boston Summit

Syntekabio (226330.KQ), a global artificial intelligence (AI) drug discovery pioneer, today announced its participation at the 20th Annual PEGS Boston – The Essential Protein & Antibody Engineering Summit, where the company will highlight its novel biologics platform. The event is being held May 13-17, 2024 at the Omni Hotel at the Seaport, Boston, MA.

11 May 2024

New AI Platform Generates Multi-Target Cancer Drug Candidates

Scientists at UC San Diego have developed a machine learning algorithm to simulate the time-consuming chemistry involved in the earliest phases of drug discovery, which could significantly streamline the process and open doors for never-before-seen treatments.

7 May 2024

Epigenomic Analysis Reveals Potential Treatment Avenues for ALS

For most patients, it's unknown exactly what causes amyotrophic lateral sclerosis (ALS), a disease characterized by degeneration of motor neurons that impairs muscle control and eventually leads to death.

3 May 2024

Mapping Small Molecule-Protein Interactions for Drug Development

For most human proteins, there are no small molecules known to bind them chemically (so called "ligands"). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines.

30 Apr 2024

Enhancing Drug Discovery Through Automated Protein Labeling

Exact protein observation in cells is crucial for many scientific fields, but it has proven to be a difficult technical task, particularly in living cells where each protein needs to have its fluorescent label applied separately.

22 Apr 2024

Unveiling Cannabinoid’s Potential for Treating Age-Related Brain Degeneration

Scientists at the Salk Institute observed the neuroprotective effects of cannabinol in fruit flies and discovered cannabinoid analogs that may prove to be promising future treatments for Parkinson's, Alzheimer's, and traumatic brain injury.

18 Apr 2024

Unlocking Bacterial Dormancy: Polyphosphates' Role Revealed

Most disease-causing bacteria are known for their speed: In mere minutes, they can double their population, quickly making a person sick.

12 Apr 2024

Designing Compounds for Next-Gen Antibiotics and Cancer Treatments

Chemists at Cold Spring Harbor Laboratory (CSHL) have generated a novel set of molecular compounds and are evaluating them as possible candidates for novel drug discovery leads.

5 Apr 2024

Study Reveals Structure of Two Nucleic Acid-Degrading Enzymes

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.

3 Apr 2024

Unveiling the Potential of the New Antibiotics Against Bacteria

A novel family of antibiotics with strong action against bacteria resistant to many drugs has been found by Uppsala University researchers, and they have demonstrated that this class of antibiotics may treat bloodstream infections in mice.

2 Apr 2024

Groundbreaking AI Framework Revolutionizes Drug Discovery

A transformative study published in Health Data Science, a Science Partner Journal, introduces a groundbreaking end-to-end deep learning framework, known as Knowledge-Empowered Drug Discovery, aimed at revolutionizing the field of drug discovery.

1 Apr 2024

Federal Regulation Urged for Direct-to-Consumer Microbiome Tests

Scientific research has linked a person's microbiome to everything from gut and mental health to immunity and predisposition to cancer.

25 Mar 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024

U of T Researchers Develop Groundbreaking Platform for Protein-Based Disease Treatment

Researchers at the University of Toronto and Sinai Health have created a new platform to identify proteins that can be co-opted to control the stability of other proteins -; a new but largely unrealized approach to the treatment of disease.

25 Mar 2024