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Mapping Gene Targets of HNF4A and HNF1A in Human Pancreatic Beta Cells and Liver Cells

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells.

26 Jun 2024

Engineered Enzyme Boosts Gene Editing Efficiency for Potential Cystic Fibrosis Treatment

Researchers at the Broad Institute of MIT and Harvard have enhanced a gene-editing technology, enabling it to efficiently insert or substitute entire genes in the genome of human cells.

11 Jun 2024

"Cervix-on-a-Chip" Offers Promise for New Bacterial Vaginosis Treatments

Bacterial Vaginosis (BV) has been identified as one of the many unmet needs in women's health and affects more than 25% of reproductive-aged women.

3 Jun 2024

The Influence of Inherited Genes on Melanoma Risk

Most people associate skin cancer warnings with sunburn and tanning beds. “Cancer genes” or inherited risks are associated with diseases such as breast and colon cancer.

22 May 2024

Mapping Neurodevelopmental Disease with High-Throughput In Vivo Perturb-seq

The brain is often referred to as a "black box"-;one that's difficult to peer inside and determine what's happening at any given moment.

21 May 2024

Genetic Analysis Sheds Light on the Role of Ribosomal DNA Copy Number in Inflammation and Disease

Ribosomal DNA (rDNA) is present in hundreds of copies in the genome, but has not previously been part of genetic analyses.

16 May 2024

New Technique Reveals Microscopic Heart Vessels with Unprecedented Clarity

A new imaging technique tested in patients could improve the evaluation of cardiac conditions and undiagnosed chest pain.

7 May 2024

Expert Insights: HiMedia Labs on Advancing Nucleic Acid Extraction Across Industries

An interview with Dr. Rajas Warke, HiMedia Laboratories' youngest director.

From Himedia Laboratories Private Limited 29 Apr 2024

UCI Researchers Receive $1.19 Million Grant to Unravel the Genetic Basis of Nicotine Addiction

A three-year, $1.19 million grant from the Tobacco-Related Disease Research Program will allow University of California, Irvine researchers to explore how specific sections of DNA might influence nicotine addiction.

26 Apr 2024

Small RNA-Binding Protein Promotes Prime Editing Efficiency

Through years of engineering gene-editing systems, researchers have developed a suite of tools that enable the modification of genomes in living cells, akin to 'genome surgery'.

23 Apr 2024

Unlocking Bacterial Dormancy: Polyphosphates' Role Revealed

Most disease-causing bacteria are known for their speed: In mere minutes, they can double their population, quickly making a person sick.

12 Apr 2024

Study Reveals Structure of Two Nucleic Acid-Degrading Enzymes

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.

3 Apr 2024

High-Resolution Map Tracks Cellular Changes During Inflammation

Cells within the intestines fulfill diverse functions, including nutrient absorption, sensing, and regulating homeostasis. Gut inflammation is a characteristic that sets certain chronic disorders apart.

3 Apr 2024

Genetic Origins of Birth Defects Discovered

A new study led by the University of California, Irvine has revealed a potential shift in our basic knowledge of the origins of birth defects, which affect about 3 percent of babies born in the United States each year.

29 Mar 2024

To Bolster Global Efforts in Combating Antibiotic-Resistant Bacteria KFSH&RC Scientists Discover New Bacteria Species: Riyadhensis

In a ground-breaking development, scientists at King Faisal Specialist Hospital and Research Centre (KFSH&RC) have identified a new species of bacteria, referred to as "Stenotrophomonas Riyadhensis" through the application of whole-genome sequencing (WGS) technology.

27 Mar 2024

Nucleus Genomics Introduces DNA Analysis Product for Personalized Medicine

Nucleus Genomics, the next-generation genetic testing and analysis company, today announced the launch of its DNA analysis product to bring the benefits of personalized medicine to everyone.

26 Mar 2024

Groundbreaking Physics Study Offers Insights Into Self-Organization of Biological Particles

Erin McCarthy '23, physics summa cum laude, is a rarity among young scientists. As an undergraduate researcher in Syracuse University's College of Arts & Sciences' Department of Physics, she guided a study that appeared in March 2024 in Physical Review Letters. It is the most-cited physics letters journal and the eighth-most cited journal in science overall.

25 Mar 2024

New Approach to Constructing Human Artificial Chromosomes Avoids Unintended Multimerization

Constructing human artificial chromosomes (HACs) in budding yeast overcomes the long-standing problem of uncontrolled multimerization – the rampant joining of similar molecules – and results in HACs that are large, stable, and structurally well-defined, researchers report.

22 Mar 2024

Non-Immune Cells Form Memory, Boosts Inflammatory Response

An essential component of adaptive immunity is immunological memory, which is the capacity to react to a foreign material or antigen more quickly and intensely when exposed again.

21 Mar 2024

Metabolic Insights into Immune Cell Activation and Response

Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

18 Mar 2024