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New gene editing approach bypasses disease-causing mutations

A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases.

From Penn State University 22 Apr 2021

Study identifies multiple genes that are frequently mutated in uterine leiomyosarcomas

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

6 Apr 2021

Study reveals mechanisms behind the activation of MRN complex

Researchers from the Tokyo Institute of Technology have revealed mechanisms behind the stimulation of the MRN complex—the DNA scissors of the cells.

11 Mar 2021

Fungal hybridization confers greater adaptive potential in Verticillium longisporum

Several plant pathogens belong to the genus Verticillium and affect many different plant hosts.

24 Feb 2021

Researchers identify tumor suppressor gene involved in stress response

Even the larvae of the Drosophila fly contain adult progenitor cells. And these cells are the only ones that are preserved throughout the growth and are responsible for the development of adult tissues and organs.

11 Feb 2021

Researchers gain a deep insight into the evolutionary history of bitter receptors

To evaluate the chemical composition of food from a physiological point of view, it is important to know the functions of the receptors that interact with food ingredients. These include receptors for bitter compounds, which first evolved during evolution in bony fishes such as the coelacanth.

3 Feb 2021

Study uncovers unusual sex chromosomes of Australian iconic animals

The sex chromosomes genetically define the developmental fate of an embryo to become a male or a female individual, and usually, appear as one pair of morphologically different chromosomes between sexes.

8 Jan 2021

Study may lead to new treatments for certain types of disease

Researchers at the Francis Crick Institute have found a new way to prevent some tumours from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments for certain types of the disease.

17 Dec 2020

Imperfect egg cells more common than originally thought

AZoLifeSciences speaks to Dr. Terry Hasssold about his latest research into oocytes and how imperfect egg cells are more common than scientists initially thought.

16 Dec 2020

Scientists identify biosynthetic genes involved in the production of usnic acid in lichens

Scientists from the Faculty of Pharmacy at the Complutense University of Madrid have headed an international study that has successfully detected a sequence of biosynthetic genes that play a key role in the synthesis of usnic acid in lichen—a kind of compound that exhibits antioxidant, antiviral, antibacterial, anticancer, and neuroprotective activity.

14 Dec 2020

Repair proteins can help healthy cells to avoid damage during cancer therapy

A key way radiation therapy and chemotherapy work is by making highly lethal double-strand breaks in the DNA of cancer cells.

10 Dec 2020

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

A research team has used a novel method that could help resolve the issue of unnecessary genetic changes encountered in the CRISPR-Cas9 technique.

7 Dec 2020

Study reveals cellular and molecular mechanisms of hypoxic stress and inflammation

Ion channels, transports, and membrane receptors are immediately delivered to defined cellular membranes once they are synthesized in the cytoplasm.

24 Aug 2020

New bioluminescent reporter tracks DNA double stranded break repair in cells

A new bioluminescent reporter that tracks DNA double stranded break (DSB) repair in cells has been developed by researchers from Massachusetts General Hospital (MGH) and the Academia Sinica in Taiwan.

24 Aug 2020

DNA repair tool is tailored to deal with specific type of complex break, study shows

Our cells are constantly dividing, and as they do, the DNA molecule - our genetic code - sometimes gets broken. DNA has twin strands, and a break in both is considered especially dangerous.

7 Jul 2020

Study sheds light on DNA sculpting properties of enigmatic protein

Sometimes, when something is broken, the first step to fixing it is to break it even more. In a recent example, scientists seeking to understand the mechanism of a DNA-repairing enzyme have discovered that the molecule performs its functions by first marking and then further breaking damaged DNA.

22 Jun 2020

Homologous News and Research

New gene editing approach bypasses disease-causing mutations

Study identifies multiple genes that are frequently mutated in uterine leiomyosarcomas

Study reveals mechanisms behind the activation of MRN complex

Fungal hybridization confers greater adaptive potential in Verticillium longisporum

Researchers identify tumor suppressor gene involved in stress response

Researchers gain a deep insight into the evolutionary history of bitter receptors

Study uncovers unusual sex chromosomes of Australian iconic animals

Study may lead to new treatments for certain types of disease

Imperfect egg cells more common than originally thought

Scientists identify biosynthetic genes involved in the production of usnic acid in lichens

Repair proteins can help healthy cells to avoid damage during cancer therapy

New method could help resolve unwanted genetic changes associated with CRISPR-Cas9 technique

Study reveals cellular and molecular mechanisms of hypoxic stress and inflammation

New bioluminescent reporter tracks DNA double stranded break repair in cells

DNA repair tool is tailored to deal with specific type of complex break, study shows

Study sheds light on DNA sculpting properties of enigmatic protein

New insights into recombination of sex chromosomes during meiosis

Study identifies brain structure that controls our behavior

Choosing alternate pathways of DNA repair to limit harmful chromosomal rearrangements

NMR spectroscopy reveals mechanisms involved in DNA repair

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