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Researchers discover a unique origin of severe pediatric brain cancer

A new cause of severe childhood brain cancer has been discovered by scientists.

25 Apr 2022

New technique controls gene activity without altering the DNA sequence of the genome

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them.

7 Mar 2022

Study findings likely to be instrumental in synthetic biology approaches

Plant geneticists can utilize a range of synthetic biology tools made by a group at Louisiana State University (LSU) to drive gene expression.

22 Feb 2022

Cancer driving protein plays crucial role in the development of lung cancer, study reveals

Lung cancer is the second leading cancer in the United States and the No. 1 cause of cancer-associated deaths.

15 Feb 2022

New gene therapy approach may help treat a wide variety of electrical heart diseases

Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice.

7 Feb 2022

Late-life exercise may alleviate epigenetic aging in skeletal muscle

For people who hate exercising, here comes some more bad news: it may also keep you younger. Not just looking younger, but actually younger, on an epigenetic level.

24 Jan 2022

Genes key to microbial colonization of plant roots discovered

Some microbes can form thin films called biofilms. These biofilms give them an advantage over other microbes by protecting them from stresses such as a lack of nutrients or the presence of harmful substances in the environment.

24 Dec 2021

Researchers identify genes responsible for “spinach teeth”

People are generally familiar with “spinach teeth,” the harmless but gritty-chalky mouthfeel triggered because of a vegetable.

23 Dec 2021

Multiple changes in brain cells during embryonic development may contribute to schizophrenia

Multiple changes in brain cells during the first month of embryonic development may contribute to schizophrenia later in life, according to a new study by Weill Cornell Medicine investigators.

17 Dec 2021

Identification of genetic variant provides a big step for precision medicine in dialysis

Every day, the human kidneys clean about 1,500 liters of blood by producing approximately 1–2 liters of urine. Thereby, the body gets rid of excess water and toxic waste products of the metabolism or also drugs and maintains the balance of water and minerals in the tissues.

21 Oct 2021

Junk DNA' plays a crucial role in early embryonic development in all mammals, study shows

Nearly half of our DNA has been written off as junk, the discards of evolution: sidelined or broken genes, viruses that got stuck in our genome and were dismembered or silenced, none of it relevant to the human organism or human evolution.

19 Oct 2021

Scientists analyze the molecular machinery of poxviruses at an atomic level

Poxviruses have found a unique way of translating their genes into proteins in the infected organism. A team of researchers from Würzburg shows for the first time how the molecular machinery involved works at an atomic level.

24 Sep 2021

CRISPR-Cas9 system could help perform very effective target gene silencing

CRISPR-Cas9's extraordinary ability to modify specific areas of DNA has made it a favorite among gene-editing tools for researchers.

6 Jul 2021

Exposure to even low levels of lead can trigger epigenetic changes

A research team from Brazil and Portugal has identified a link between a microRNA (miRNA) and the presence of lead in an organism.

18 May 2021

Supercoiling characteristic of DNA's structure controls gene expression, research shows

The two meters of -stretched- DNA contained in human cells are continuously twisting and untwisting to give access to genetic information: when a gene is expressed to generate a protein, the two strands of DNA are separated to give access to all the machinery necessary for this expression, resulting in an excessive accumulation of coiling that needs to be resolved later.

10 May 2021

New gene editing approach bypasses disease-causing mutations

A new approach to gene editing using the CRISPR/Cas9 system bypasses disease-causing mutations in a gene, enabling treatment of genetic diseases linked to a single gene, such as cystic fibrosis, certain types of sickle cell anemia, and other rare diseases.

From Penn State University 22 Apr 2021

Study reveals DNA supercoiling is involved in regulating gene expression

The (when stretched) two-meter-long DNA molecule in each human cell is continuously being unpacked and packed again to enable the expression of genetic information.

15 Apr 2021

CSHL investigator aims to predict the effects of mutations on different tomato varieties

Both people and tomatoes come in different shapes and sizes. That is because every individual has a unique set of genetic variations--mutations--that affect how genes act and function. Added together, millions of small genetic variations make it hard to predict how a particular mutation will impact any individual.

13 Apr 2021

New mechanism of transcriptional regulators influences tumor development

The Wistar Institute scientists have discovered a novel mechanism of transcriptional regulation of cellular senescence that promotes the release of inflammatory molecules that, in turn, affect tumor growth by changing the surrounding microenvironment.

2 Apr 2021

Researchers use CRISPR to tinker with corn kernel numbers

Corn--or maize--has changed over thousands of years from weedy plants that make ears with less than a dozen kernels to the cobs packed with hundreds of juicy kernels that we see on farms today. Powerful DNA-editing techniques such as CRISPR can speed up that process.

23 Feb 2021