Signaling Pathway News and Research

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New Genetic Mutations Linked to Canine Bladder Cancers Identified

Researchers have identified new genetic mutations linked to a subset of canine bladder cancers. Their findings have implications both for early cancer detection and for targeted treatments in dogs and humans.

26 Apr 2023

New Mechanism Controlling Cellular Proliferation in Response to Serum Revealed

Researchers of the Genome Dynamics Project team at Tokyo Metropolitan Institute of Medical Science revealed new mechanism controlling cellular proliferation in response to serum, which triggers growth of resting cells.

13 Apr 2023

Stimulating Beige Fat Production Could Help Reverse the Effects of Age-Related Slowing Metabolism

New research suggests a strategy to ward off age-related weight gain, which could prevent obesity and associated health disorders like Type 2 diabetes, heart disease and chronic inflammation.

7 Apr 2023

KAI2-Ligand Signaling Pathway Responsible for Regulating Vegetative Reproduction in Liverwort Plants

Asexual, or vegetative, reproduction in plants is controlled by environmental conditions, but the molecular signaling pathways that control this process are poorly understood.

3 Apr 2023

Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer That...

Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.

29 Mar 2023

Study identifies previously unknown cell types that drive the onset of osteoarthritis

A Michigan Medicine study has identified a new potential target for treating osteoarthritis – a debilitating joint disease that affects over 31 million Americans and is a leading cause of disability worldwide.

10 Mar 2023

Using nanoparticles to carry drugs across the blood-brain barrier

Brain tumors are notoriously hard to treat. One reason is the challenge posed by the blood-brain barrier, a network of blood vessels and tissue with closely spaced cells.

3 Mar 2023

Robust method for induced pluripotent stem cell culture

Different types of cells, such as the heart, liver, blood, and sperm cells, have characteristics that help them perform their specific functions in the body. In general, those traits are hard-wired. A heart cell will not randomly transform into a liver cell if not stimulated.

23 Feb 2023

LMU physician explores the causes of high susceptibility to deadly infections in prematurely born babies

LMU physician Markus Sperandio has discovered why the immune system of prematurely born babies is not working properly after birth.

23 Feb 2023

Study reveals the mechanisms that prevent effective cancer cell death

Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes. Mutations in tumor suppressor genes can allow tumors to grow unchecked – a case of no brakes – while mutations in oncogenes can activate cell proliferation, pushing the gas pedal all the way to the floor.

14 Feb 2023

A treatment strategy to hasten cancer cell death

Gene mutations are the cause of cancer. Tumor suppressors and oncogenes are the two main groups of these altered genes in cancer. Mutations in oncogenes can drive cell proliferation, pushing the gas pedal to the floor, whereas mutations in tumor suppressor genes can cause tumors to grow unchecked—a situation in which there is no control.

13 Feb 2023

Massive clinical study on type 1 diabetes patients

A massive clinical study on an approved psoriasis drug is now underway. The drug will be tested on people who have just been diagnosed with type 1 diabetes. The drug, according to the theory, could preserve the patient’s remaining insulin production.

30 Jan 2023

Grasping how a biological pathway causes stem cells to regenerate or die

According to a recent study conducted by Cedars-Sinai and the University of California, San Francisco (UCSF), altering a cellular process can cause stem cells, which are the cells that give rise to all other types of body cells, to either die or regenerate.

18 Jan 2023

New gene helps drive the development of the common lung cancer type

At the NYU Langone Health’s Perlmutter Cancer Center, a team headed by scientists has determined a gene that forces the development of the second most common type of lung carcinoma.

From New York University (NYU) 11 Jan 2023

Deubiquitinating enzymes vital for endosomal transport identified

The University of Konstanz’s Plant Physiology and Biochemistry research group has discovered previously unrecognized molecular mechanisms by which plants acclimatize to their environment—vital basic knowledge in times of climate change.

28 Nov 2022

The critical role of amino acid sensing pathways in driving colorectal cancer

A dietary modification may be essential to improving colon cancer treatment, according to research from the University of Michigan Rogel Cancer Center.

22 Nov 2022

Mitochondria play a crucial role in the regulation of the NF-κB signaling pathway

Mitochondria are highly regarded as the cell's powerhouse. However, these cellular organelles are essential for more than only energy production: Professor Konstanze Winklhofer and her colleagues at Ruhr University Bochum’s Faculty of Medicine have found that mitochondria play an essential role in signal transduction in innate immune pathways.

21 Nov 2022

Low protein synthesis in humans causes rare intestinal disease

According to a recent study, which will be published on November 1st, 2022, by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues, a decrease in protein synthesis in growing gut cells contributes to a rare genetic condition, and an affordable nutritional supplement could help reverse that decrease.

3 Nov 2022

Scientists uncover the robust mechanism used by insects

Researchers at IRB Barcelona, under the direction of Dr Marco Milan, have identified a very robust system that insects use for wing formation and regeneration.

25 Aug 2022

Biotrophic fungus uses host auxin signaling pathway for its own purposes

Ustilago maydis attacks and reproduces in the aerial parts of the corn plant. At the location of the infection, massive tumor-like tissue growths frequently develop. The size of these galls can exceed that of a child’s skull.

12 Aug 2022