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CAR T-cell therapy effective in mice with ovarian cancer

CAR T-cell therapy, a certain kind of cancer treatment in which the immune system's T cells are programmed to attack tumor cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer.

6 Feb 2023

Antibody that blocks VEGF-B could be a potential therapeutic option for fatty liver disease

There is currently no drug for treating non-alcoholic fatty liver disease, which affects many people with type 2 diabetes and which can result in other serious liver diseases.

6 Feb 2023

Non-immunosuppressive strategy mitigates immune-mediated intestinal diseases

The severity of immune-mediated intestinal diseases like graft-versus-host disease (GVHD) or inflammatory bowel disease is known to be associated with changes in the gut microbiome, but what causes such disruption in the microbial community is unknown.

3 Feb 2023

Losartan prevents immunotherapy-related edema, improves survival in glioblastoma mouse models

Patients with glioblastoma-;the deadliest type of primary brain tumor-;may potentially benefit from immunotherapy medications called immune checkpoint inhibitors that stimulate an immune response against cancer cells.

3 Feb 2023

Easy-to-use method quantifies exosomal miRNAs

Most cancer diagnostic procedures, like endoscopies, biopsies, and mammograms, are stressful and invasive. Although blood samples may be a less unpleasant option, only a few forms of the disease can as of now be diagnosed this way.

2 Feb 2023

Deletion of p16Ink4a cells does not negatively impact β-cell mass and proliferation in mice

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 2, entitled, "Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity."

1 Feb 2023

UNC research describes another layer to the challenge of HIV latency

When people living with HIV take antiviral therapy (ART), their viral loads are driven so low that a standard blood test cannot detect the virus.

1 Feb 2023

Research supports the safety and efficacy of COVID-19 vaccination in cancer patients receiving immunotherapy

Research findings published in Frontiers in Immunology show that cancer immunotherapy does not interfere with COVID-19 immunity in previously vaccinated patients.

1 Feb 2023

CHOP scientists build a custom tool that drastically reduces engraftment reporting error rates

Researchers at Children's Hospital of Philadelphiahave developed a custom-built application to automate determination of engraftment, a key outcome after hematopoietic stem cell transplant (HSCT).

31 Jan 2023

Effective new drugs to reduce the massive number of malaria cases

Malaria is known as a disastrous disease, with 247 million cases and 619,000 deaths reported in 2021 alone.

From The University of New South Wales (UNSW) 31 Jan 2023

Cedars-Sinai's Stem Cell and Bone Marrow Transplant Program recognized with two hallmarks of quality

The Stem Cell and Bone Marrow Transplant Program at Cedars-Sinai Cancer was recently recognized with two important hallmarks of quality: official accreditation for CAR T-cell therapy, and a third year in a row ranking among the top adult bone marrow transplant programs in the U.S.

31 Jan 2023

Anti-aging gene found in centenarians can rewind the heart's biological age by 10 years

An anti-aging gene discovered in a population of centenarians has been shown to rewind the heart's biological age by 10 years.

31 Jan 2023

Massive clinical study on type 1 diabetes patients

A massive clinical study on an approved psoriasis drug is now underway. The drug will be tested on people who have just been diagnosed with type 1 diabetes. The drug, according to the theory, could preserve the patient’s remaining insulin production.

30 Jan 2023

Long-term deep meditation may have a beneficial effect on gut microbiota, study suggests

Regular deep meditation, practised for several years, may help to regulate the gut microbiome and potentially lower the risks of physical and mental ill health, finds a small comparative study published in the open access journal General Psychiatry.

30 Jan 2023

Newly discovered genetic mutation may be a root cause of severe cases of childhood glaucoma

An international team of scientists led by Mass Eye and Ear, a member of Mass General Brigham, and Boston Children's Hospital, has discovered a new genetic mutation that may be a root cause of severe cases of childhood glaucoma, a devastating condition that runs in families and can rob children of their vision by 3 years of age.

30 Jan 2023

Novel adoptive T cell receptor therapy shows promising results for patients with solid tumors

Afamitresgene autoleucel (afami-cel; formerly ADP-A2M4), an adoptive T cell receptor (TCR) therapy targeting the MAGE-A4 cancer antigen, achieved clinically significant results for patients with multiple solid tumor types in a Phase I clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.

30 Jan 2023

New spray can prevent infections and kill antibiotic-resistant bacteria

The World Health Organization ranks antibiotic resistance as one of the top ten threats to global health. There is therefore a great need for new solutions to tackle resistant bacteria and reduce the use of antibiotics.

27 Jan 2023

Flexible copper sensor detects heavy metals in sweat

Heavy metals such as lead and cadmium are present in batteries, cosmetics, food and other things that are part of everyday life.

24 Jan 2023

New genetic condition that raises vulnerability to opportunistic infections

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including life-threatening fungal pneumonia.

24 Jan 2023

Role of clonal hematopoiesis as a broad driver of atherosclerosis

A group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), collaborating with institutions in the USA, has shown that acquired mutations in the gene encoding the protein p53 contribute to the onset of atherosclerotic cardiovascular disease.

18 Jan 2023

Blood News and Research

CAR T-cell therapy effective in mice with ovarian cancer

Antibody that blocks VEGF-B could be a potential therapeutic option for fatty liver disease

Non-immunosuppressive strategy mitigates immune-mediated intestinal diseases

Losartan prevents immunotherapy-related edema, improves survival in glioblastoma mouse models

Easy-to-use method quantifies exosomal miRNAs

Deletion of p16Ink4a cells does not negatively impact β-cell mass and proliferation in mice

UNC research describes another layer to the challenge of HIV latency

Research supports the safety and efficacy of COVID-19 vaccination in cancer patients receiving immunotherapy

CHOP scientists build a custom tool that drastically reduces engraftment reporting error rates

Effective new drugs to reduce the massive number of malaria cases

Cedars-Sinai's Stem Cell and Bone Marrow Transplant Program recognized with two hallmarks of quality

Anti-aging gene found in centenarians can rewind the heart's biological age by 10 years

Massive clinical study on type 1 diabetes patients

Long-term deep meditation may have a beneficial effect on gut microbiota, study suggests

Newly discovered genetic mutation may be a root cause of severe cases of childhood glaucoma

Novel adoptive T cell receptor therapy shows promising results for patients with solid tumors

New spray can prevent infections and kill antibiotic-resistant bacteria

Flexible copper sensor detects heavy metals in sweat

New genetic condition that raises vulnerability to opportunistic infections

Role of clonal hematopoiesis as a broad driver of atherosclerosis

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