Laboratory News and Research

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New Device Enables Construction of Complex 3D Organoids Without Using Elaborate Techniques

A team led by Masaya Hagiwara of RIKEN national science institute in Japan has developed an ingenious device, using layers of hydrogels in a cube-like structure, that allows researchers to construct complex 3D organoids without using elaborate techniques.

10 Apr 2023

Viruses Interact with a Far More Diverse Set of Hosts than was Previously Thought

Viruses are the most abundant and diverse biological entities on Earth, living in every type of habitat. In the ocean alone viruses are ten times more abundant than microbes.

7 Apr 2023

Evolutionary Encounter of Two Protein Components Could Occur Entirely by Chance

Proteins are the key players for virtually all molecular processes within the cell. To fulfil their diverse functions, they have to interact with other proteins.

7 Apr 2023

Promoting Gut Health in Mice with Broccoli Consumption

It is well known that broccoli is good for human health. For instance, studies have indicated that increasing the intake of cruciferous vegetables lowers the risk of type 2 diabetes and cancer.

7 Apr 2023

Attacking the HTLV-1 Virus With the Help of Special Gene Scissors

HTLV-1 triggers aggressive forms of leukemia or an incurable spinal cord disease that leads to paralysis: the virus is the often ignored but no less insidious sibling of the HIV virus that causes AIDS and also belongs to the family of retroviruses.

6 Apr 2023

Revealing how cohesin attaches to the DNA and forms loops

Ana Losada, a scientist at the Spanish National Cancer Research Centre (CNIO) and then at the Cold Spring Harbor Laboratory, identified cohesin, a protein essential to the process of cell division, in Xenopus frogs at the end of the 1990s.

5 Apr 2023

Male Beetles Neglect Maintenance of Gametes When Competing for Mating Opportunities

Male beetles face a trade-off between competing with other males for mating opportunities and repairing damage to their sperm DNA, according to a study publishing April 4th in the open access journal PLOS Biology by Mareike Koppik from Uppsala University, Sweden, and colleagues.

5 Apr 2023

New Shape-Shifting Antibiotics may Help Combat Drug-Resistant Superbugs

In the United States alone, drug-resistant bacteria and fungi infect almost 3 million people per year and kill about 35,000. Antibiotics are essential and effective, but in recent years overuse has led to some bacteria developing resistance to them.

5 Apr 2023

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

Each person has about 4 million sequence differences in their genome relative to the reference human genome.

4 Apr 2023

Newly Identified Rare Genetic Variants Could Point to One of the General Mechanisms Driving AMD

A study from the National Eye Institute (NEI) identified rare genetic variants that could point to one of the general mechanisms driving age-related macular degeneration (AMD), a common cause of vision loss in older adults.

3 Apr 2023

New cold "coping" mechanism of plants could offer solutions to breeding more climate resilient crops

On bright chilly mornings you can either snuggle down under the duvet or leap up and seize the day.

31 Mar 2023

First atomic-level structure of 'oil-eating' enzyme paves way for bioengineered catalysts

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have produced the first atomic-level structure of an enzyme that selectively cuts carbon-hydrogen bonds-;the first and most challenging step in turning simple hydrocarbons into more useful chemicals.

31 Mar 2023

Personal genome sequencing and personalized medicine

Genetic mutations have given life on Earth a stunning variety of various sizes, colors, and shapes. Some changes are beneficial, while others are dangerous or ineffective. There are about 4.5 million genetic variants per individual.

31 Mar 2023

Gene variants that improve nitrogen utilization identified

Nitrogen as a fertilizer can boost yields. Too much nitrogen, on the other hand, can have negative consequences such as high energy consumption in fertilizer manufacturing.

31 Mar 2023

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

A new study conducted at the National Eye Institute (NEI) has identified incredibly rare genetic variants that might uncover the mechanisms underlying the development of AMD.

31 Mar 2023

Study helps understand at the cellular level how physical activity contributes to fitness during aging

Regular exercise can guarantee quality of life and longevity, specialists agree. However, exactly how exercise influences the functioning of muscle cells is poorly understood.

30 Mar 2023

COVID-19 vaccines boost the levels of T cells in immunocompromised hematology patients

Researchers found that, despite being heavily immunocompromised, hematology patients generate strong cellular immune responses against SARS-CoV-2 after vaccination, on par with that of healthy individuals.

30 Mar 2023

FDA-approved compound promotes photoreceptor survival in lab models of inherited retinal ciliopathy

A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

30 Mar 2023

SARS-CoV-2 infection hijacks and damages parts of infected cells' vital RNA machinery

Coronavirus disease (COVID-19) hijacks parts of infected cells' vital RNA machinery, thereby blocking important functions in the cells. These damaging changes in the RNA can likely be reversed, potentially leading to new drugs against COVID-19, University of Gothenburg researchers show.

30 Mar 2023

Epigenetic fingerprinting helps trace the origin of animal products

Food analysis laboratories can provide an answer to questions like “Was the salmon for dinner really caught wild or did it come from aquaculture? What to make of the alleged ‘biolabel quality’ of the shrimp for the seafood salad? And was the chicken for the Sunday roast really allowed to spend its life in the open air?” to a limited extent.

30 Mar 2023

Laboratory News and Research

New Device Enables Construction of Complex 3D Organoids Without Using Elaborate Techniques

Viruses Interact with a Far More Diverse Set of Hosts than was Previously Thought

Evolutionary Encounter of Two Protein Components Could Occur Entirely by Chance

Promoting Gut Health in Mice with Broccoli Consumption

Attacking the HTLV-1 Virus With the Help of Special Gene Scissors

Revealing how cohesin attaches to the DNA and forms loops

Male Beetles Neglect Maintenance of Gametes When Competing for Mating Opportunities

New Shape-Shifting Antibiotics may Help Combat Drug-Resistant Superbugs

New Resource Provides a Better Annotation of the Genome and Understanding of Variant Impact

Newly Identified Rare Genetic Variants Could Point to One of the General Mechanisms Driving AMD

New cold "coping" mechanism of plants could offer solutions to breeding more climate resilient crops

First atomic-level structure of 'oil-eating' enzyme paves way for bioengineered catalysts

Personal genome sequencing and personalized medicine

Gene variants that improve nitrogen utilization identified

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

Study helps understand at the cellular level how physical activity contributes to fitness during aging

COVID-19 vaccines boost the levels of T cells in immunocompromised hematology patients

FDA-approved compound promotes photoreceptor survival in lab models of inherited retinal ciliopathy

SARS-CoV-2 infection hijacks and damages parts of infected cells' vital RNA machinery

Epigenetic fingerprinting helps trace the origin of animal products

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