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Potential approach to improve solid tumor T cell therapy

Researchers at the Perelman School of Medicine at the University of Pennsylvania have been working on a preclinical study that focuses on a new strategy that uses a “one-two punch” to assist T cells in attacking solid tumors.

17 Mar 2023

Study reveals: Coronaviruses that cause common colds boost immune response to COVID-19

During the pandemic, it became clear that children who contracted COVID-19 became less ill than adults. One hypothesis has been that common colds would give children immunity protecting against a severe form of the disease. Researchers at Karolinska Institutet are now able to show that OC43, one of the coronaviruses that cause common colds, boosts the immune response to COVID-19. The study, which is published in PNAS, could give rise to more tailored vaccine programmes for children and adults.

16 Mar 2023

Artificial pancreas helps improve blood sugar control in children with type 1 diabetes

An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study.

16 Mar 2023

High blood caffeine levels lower body fat and the long-term risks of type 2 diabetes, study finds

A high blood caffeine level might curb the amount of body fat a person carries and their risk of type 2 diabetes, suggests research published in the open access journal BMJ Medicine.

16 Mar 2023

Novel newborn screening test for HCU works by measuring homocysteine levels

Scientists have developed a test that could greatly improve quality of life for infants with homocystinuria (HCU)-;a congenital disease that, if not treated early, causes serious complications. Research demonstrating the efficacy of this test was published today in AACC's Clinical Chemistry journal.

16 Mar 2023

Study examines the role of dietary vitamin A in preventing or treating AAP

Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment.

16 Mar 2023

Study reveals the detrimental effects of even a few extra pounds on young people

A Kaiser Permanente study of more than 800,000 young people between the ages of 3 and 17 showed that youth at the upper range of average weight had a 26% higher risk of developing hypertension than those closer to what is considered average weight. The study was published March 14, 2023, in JAMA Network Open.

15 Mar 2023

High correlation between the product of a gene in the majority of cancers

The product of a gene expressed in most cancers, including the most prevalent type of head and neck cancer, has been linked to elevated levels of white blood cells that produce antibodies inside tumors, according to researchers at the University of California San Diego School of Medicine and UC San Diego Moores Cancer Center.

14 Mar 2023

Novel technology easily detects active Mycobacterium tuberculosis infection antibodies

A team of faculty from Wayne State University has discovered new technology that will quickly and easily detect active Mycobacterium tuberculosis (TB) infection antibodies.

14 Mar 2023

Developing new therapies that leverage the host immune system

Yersinia bacteria cause a variety of human and animal diseases, the most notorious being the plague, caused by Yersinia pestis. A relative, Yersinia pseudotuberculosis, causes gastrointestinal illness and is less deadly but naturally infects both mice and humans, making it a useful model for studying its interactions with the immune system.

14 Mar 2023

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Microorganisms live in or on almost every part of the human body and play an important role in the regulation of normal human processes. As a result, changes in the number or type of microorganisms, also known as the microbiome, can contribute to disease and altered responses to therapy, including cancer treatment.

14 Mar 2023

Investigating the potential cellular effects of C-reactive protein

The biological function of the C-reactive protein, CRP, has long been unidentified. Investigators at LiU have discovered that this protein has a useful function in the inflammatory disease systemic lupus erythematosus or SLE.

10 Mar 2023

Experts receive funding to analyze individualized hemodialysis as a dynamic treatment

The Patient-Centered Outcomes Research Institute (PCORI) recently awarded researchers at Wake Forest University School of Medicine $10.2 million to study the effectiveness of an individualized model of hemodialysis, a procedure in which the blood is cleaned by a dialysis machine. The project is a collaboration between the School of Medicine, the Renal Research Institute and other health care systems across the country.

10 Mar 2023

Study identifies a novel rare mutation in gene linked to Harlequin Ichthyosis

Harlequin ichthyosis (HI) is a severe genetic skin disorder characterized by thick white, brown, or dark brown patches on the skin covering a newborn's entire body. HI has a low incidence of 1 per 300,000 live births but comes with the highest mortality rate among skin conditions. It is caused by a mutation in the ABCA12 gene, which codes for a protein involved in transporting lipids necessary for the formation of the skin barrier. Such protein shortage leads to a weaker epidermal barrier.

9 Mar 2023

Potential therapeutic can synergize with existing drugs to effectively destroy leukemia cells

A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells.

9 Mar 2023

Deeper understanding of T-cell responses may lead to better, more personalized immunotherapies

For the first time, a research team has identified and analyzed the steps by which immune cells "see" and respond to cancer cells, providing insights into reasons some treatments may be effective for certain patients but not others.

9 Mar 2023

Pentamer shape of C-reactive protein can suppress the immune response in inflammatory disease

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers at Linköping University in Sweden now show that this protein has a beneficial function in systemic lupus erythematosus, SLE, an inflammatory disease.

9 Mar 2023

Monitoring the development and maturation of cardiomyocytes using tissue-embedded devices

Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.

9 Mar 2023

Study findings reveal drug development possibilities for brain diseases

Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer's disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms.

9 Mar 2023

Liver-produced hormone protects mice against the harmful effects of intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study.

8 Mar 2023

Blood News and Research

Potential approach to improve solid tumor T cell therapy

Study reveals: Coronaviruses that cause common colds boost immune response to COVID-19

Artificial pancreas helps improve blood sugar control in children with type 1 diabetes

High blood caffeine levels lower body fat and the long-term risks of type 2 diabetes, study finds

Novel newborn screening test for HCU works by measuring homocysteine levels

Study examines the role of dietary vitamin A in preventing or treating AAP

Study reveals the detrimental effects of even a few extra pounds on young people

High correlation between the product of a gene in the majority of cancers

Novel technology easily detects active Mycobacterium tuberculosis infection antibodies

Developing new therapies that leverage the host immune system

Understanding the relationship between gut microbiome and CAR T-cell therapy response

Investigating the potential cellular effects of C-reactive protein

Experts receive funding to analyze individualized hemodialysis as a dynamic treatment

Study identifies a novel rare mutation in gene linked to Harlequin Ichthyosis

Potential therapeutic can synergize with existing drugs to effectively destroy leukemia cells

Deeper understanding of T-cell responses may lead to better, more personalized immunotherapies

Pentamer shape of C-reactive protein can suppress the immune response in inflammatory disease

Monitoring the development and maturation of cardiomyocytes using tissue-embedded devices

Study findings reveal drug development possibilities for brain diseases

Liver-produced hormone protects mice against the harmful effects of intoxication

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