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Chemical Modification Improves Non-Viral Gene Editing as Well as a New Type of DNA Repair

Gene editing is a powerful method for both research and therapy. Since the advent of the Nobel Prize-winning CRISPR/Cas9 technology, a quick and accurate tool for genome editing discovered in 2012, scientists have been working to explore its capabilities and boost its performance.

12 May 2023

Researchers Show a Second Key Gene Involved in Malaria's Resistance to Chloroquine

How malaria parasites evolved to evade a major antimalarial drug has long been thought to involve only one key gene.

12 May 2023

Prime Editing System Could Accelerate the Study of Cancer-Linked Mutations

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development.

12 May 2023

How the Natural Process of DNA Repair Fails to Cause Disease

We often come to an understanding of what causes a disease. We know, for example, that cancers are caused by mutations at critical locations in the genome, resulting in loss of control of cell growth.

11 May 2023

Researchers Use Cheese Rinds to Show Fungal Antibiotics Can Influence Microbiome Development

Fungi produce metabolites that humans have used to improve health. For example, they secrete penicillin, which is then purified and used as an antibiotic for humans, leading to the development of many other antibiotics.

11 May 2023

Genetic Material Inherited from Neanderthals Influences the Shape of Our Noses

Humans inherited genetic material from Neanderthals that affects the shape of our noses, finds a new study led by UCL researchers.

9 May 2023

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

5 May 2023

Innate Tumor Suppression Mechanism Uncovered

The p53 gene is one of the most important in the human genome: the only role of the p53 protein that this gene encodes is to sense when a tumor is forming and to kill it.

5 May 2023

Understanding How Supernumerary Chromosomes Arise

The majority of chromosomes have existed for millions of years.

5 May 2023

Study Uncovers Cancer-Like Changes in Mitochondrial Disease of Newborns

A study found that a mitochondrial disease of newborns shows cancer-like changes in proliferating cells, causing tissues to age prematurely.

4 May 2023

Researchers Map GCK Gene Variants to Better Diagnose Hereditary Diseases

Researchers at the Department of Biology, University of Copenhagen, have now contributed to solving this problem for a specific gene called GCK. The study has just been published in Genome Biology.

4 May 2023

Study Advances Understanding of the Deep Evolutionary History of Viruses

Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.

3 May 2023

Study Reveals That Transcriptional Buffering Occurs in Rett Syndrome Nerve Cells

Every cell in our body is able to turn genes (DNA) on or off, producing RNA, but when genes are 'turned on' to the wrong level it can result in a variety of health conditions.

3 May 2023

Texas A&M Research Provides a Definitive Answer to the Evolutionary Timeline of Mammals

Research led by a team of scientists from the Texas A&M School of Veterinary Medicine and Biomedical Sciences puts to bed the heated scientific debate regarding the history of mammal diversification as it relates to the extinction of the non-avian dinosaurs.

2 May 2023

Newly Identified Broad-Spectrum Antivirals Can Target Multiple Families of RNA Viruses

A new study has identified potential broad-spectrum antiviral agents that can target multiple families of RNA viruses that continue to pose a significant threat for future pandemics.

2 May 2023

New Approach Could Power the Development of Advanced Cell Therapies

A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods.

2 May 2023

Study Uncovers Somatic Mutations That Play a Role in Common Form of Adult Epilepsy

Epilepsy affects approximately 1-in-26 people and the most common form, known as temporal lobe epilepsy (TLE), often cannot be adequately treated with anti-seizure medications.

2 May 2023

Genome Sequencing of 'Lablab Bean' Paves Way for Wider Cultivation of the African Crop

An international team of researchers has fully sequenced the genome of a climate-resilient bean that could bolster food security in drought-prone regions.

2 May 2023

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Recent research from Temple University’s Lewis Katz School of Medicine and the University of Nebraska Medical Center demonstrates that gene-editing therapy aimed at two targets - HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that aids the virus getting into cells—can effectively eliminate HIV infection.

2 May 2023

Markers Indicating Early Signs of Schizophrenia Identified

For the first time, a global study group headed by investigators at Virginia Commonwealth University has found markers that might point out early if a person is susceptible to schizophrenia in the early stage itself.

28 Apr 2023

Genome News and Research

Chemical Modification Improves Non-Viral Gene Editing as Well as a New Type of DNA Repair

Researchers Show a Second Key Gene Involved in Malaria's Resistance to Chloroquine

Prime Editing System Could Accelerate the Study of Cancer-Linked Mutations

How the Natural Process of DNA Repair Fails to Cause Disease

Researchers Use Cheese Rinds to Show Fungal Antibiotics Can Influence Microbiome Development

Genetic Material Inherited from Neanderthals Influences the Shape of Our Noses

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

Innate Tumor Suppression Mechanism Uncovered

Understanding How Supernumerary Chromosomes Arise

Study Uncovers Cancer-Like Changes in Mitochondrial Disease of Newborns

Researchers Map GCK Gene Variants to Better Diagnose Hereditary Diseases

Study Advances Understanding of the Deep Evolutionary History of Viruses

Study Reveals That Transcriptional Buffering Occurs in Rett Syndrome Nerve Cells

Texas A&M Research Provides a Definitive Answer to the Evolutionary Timeline of Mammals

Newly Identified Broad-Spectrum Antivirals Can Target Multiple Families of RNA Viruses

New Approach Could Power the Development of Advanced Cell Therapies

Study Uncovers Somatic Mutations That Play a Role in Common Form of Adult Epilepsy

Genome Sequencing of 'Lablab Bean' Paves Way for Wider Cultivation of the African Crop

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Markers Indicating Early Signs of Schizophrenia Identified

Genetics & Genomics - Second Edition eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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