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Single-Cell Analysis Uncovers Impact of TREM2 Mutation on Beta-Amyloid Plaques

Researchers led by the University of California, Irvine have discovered how the TREM2 R47H genetic mutation causes certain brain areas to develop abnormal protein clumps, called beta-amyloid plaques, associated with late-onset Alzheimer's disease.

8 Aug 2024

Mini-Gut Model Unlocks Secrets of COVID-19 Diarrhea

Researchers at Johns Hopkins Medicine claim to have identified multiple molecular pathways linked to diarrhea caused by COVID-19, offering possible therapeutic interventions utilizing human stem cells to create a sort of “mini intestine-in-a-dish.

7 Aug 2024

Mast Cells Recruit Neutrophils in Immune Response

Mast cells are well-known for their part in allergic reactions, but the immune system relies heavily on them. They release chemicals in response to allergens, which cause common allergy symptoms like tissue swelling and inflammation.

5 Aug 2024

Breakthrough Method Captures Aging Impact on Alzheimer’s Disease in Lab-Grown Neurons

Researchers at Washington University School of Medicine in St. Louis have developed a way to capture the effects of aging in the development of Alzheimer's disease.

2 Aug 2024

New Study Links Keloid Formation to Microbiome Imbalance

A study explores the microbiome of keloids, which are treatment-resistant raised scars. Some wounds heal completely; some wounds leave a scar; and some wounds leave a noticeable raised and growing bump larger than the original wound called a keloid.

1 Aug 2024

Swabbing Technique Reveals Diversity of Immune Cells in the Upper Airway

Scientists at La Jolla Institute for Immunology (LJI) have published the first-ever, in-depth analysis of immune cell memory in the upper airways of adult volunteers. Among these immune cells, the researcher spotted "tissue resident" memory cells, which stand ready to defend the airway from SARS-CoV-2 and other respiratory diseases.

1 Aug 2024

Uncovering the Molecular Mechanisms Underlying Liver Regeneration

The liver can renew itself quite well. Maintaining organ function and recuperating from surgery or injury depends on this quality. Using clinical samples, researchers from the University of Leipzig Medical Center, the Max Planck Institute for Evolutionary Anthropology, TU Dresden, and ETH Zurich have examined the changes in liver cell types before and following regeneration.

31 Jul 2024

IL-22BP Protein's Influence on Gut Microbiota and Infection Response Revealed

A study reported in Proceedings of the National Academy of Sciences (PNAS) shows how the presence of a specific protein called IL-22BP affects the composition of the gut microbiota and the body's response to bacterial infection.

30 Jul 2024

Harvard Researchers Crack the Code on Western Equine Encephalitis Decline

The story of the rise and fall of western equine encephalitis as a lethal disease offers essential lessons about how a pathogen can gain or lose its ability to jump from animals to humans.

29 Jul 2024

New ProteoCHIP EVO 96 Boosts Single-Cell Proteomics Sensitivity and Throughput

A label-free single-cell proteomics workflow that integrated the automated sample handling, optimal ion usage, and high-throughput capacities.

18 Jul 2024

How an obesity gene influences brain function

A complex condition, obesity is brought on by a confluence of factors including behavior, diet, and heredity. Getting enough food to survive and thrive was a challenge for millennia.

16 Jul 2024

Macrophage Inflammation may Contribute to LSD Symptoms

Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).

15 Jul 2024

UQ Researchers Reveal Mechanism of Immune Evasion by Haemophilus influenzae

Researchers from The University of Queensland have identified how a common bacterium is able to manipulate the human immune system during respiratory infections and cause persistent illness.

12 Jul 2024

New Insights into ILC2 Development Could Lead to Innovative Therapies for Allergic Diseases

Scientists have discovered a novel mechanism of ILC2 immune cell development which may be involved in exacerbating allergic diseases.

11 Jul 2024

Retron-Based Tool Enables Multi-Site DNA Editing

Genome editing has become a widely adopted technology to modify DNA in cells, allowing scientists to study diseases in the lab and develop therapies that repair disease-causing mutations.

10 Jul 2024

Scientists develop first fully functional human immune system in mouse model

Researchers at The University of Texas Health Science Center in San Antonio have produced a mouse model that is humanized, complete with a human immune system and a gut microbiome that resembles that of a human being and is able to elicit particular antibody responses.

8 Jul 2024

Study Reveals Epigenetic Changes in Sperm from Non-Genetic Infertility Causes

How non-genetic factors can induce epigenetic modifications to the sperm and cause male infertility.

3 Jul 2024

Study Highlights MSC-EVs Potential for Alleviating Lung Fibrosis

Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation, causing structural damage and lung failure.

27 Jun 2024

Scientists Identify Gene Region that Fuels Asthma Inflammation

Pollen and house dust mites are two common allergens that cause respiratory distress in asthma patients. But type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s) release a class of proteins known as type-2 cytokines in response to a variety of asthma triggers. GATA-binding protein 3 (GATA3) is essential for the maturation of Th2 and ILC2.

25 Jun 2024

Researchers Develop New Way to Simulate Personalized, Microbiome-Mediated Diet Responses

Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more.

25 Jun 2024