Knockout News and Research

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Groundbreaking field trials underscore the potential of gene-editing technology

Field trials that explore healthy chemicals in agronomically significant brassica crops have underscored the “immense potential” of gene-editing technology.

22 Jun 2021

ASU study reveals how diets high in saturated fats cause colon cancer

For decades, physicians and dieticians have urged people to limit their intake of high fat foods, citing links to poor health outcomes and some of the leading causes of death in the U.S., such as diabetes, heart disease and cancer.

10 Jun 2021

Lack of functional GAS2 gene causes severe hearing impairment in mice

A gene called GAS2 plays a key role in normal hearing, and its absence causes severe hearing loss, according to a study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.

10 May 2021

Protein in skeletal muscular system may play a key role in the body's fight or flight response

Researchers at the University of Cincinnati say a regulatory protein found in skeletal muscle fiber may play an important role in the body's fight or flight response when encountering stressful situations.

26 Apr 2021

Strong cell-cell junctions preserve the quiescent properties of stem cells

The skin is known to be the largest organ in the human body, and its outermost layer, called the epidermis, is renewed every three weeks.

29 Mar 2021

Specific protein helps insect-eating plants trap their prey

A Venus flytrap will shut immediately just at the brush of an insect’s wing.

26 Mar 2021

Noncoding RNA plays key role in sepsis, regulates inflammatory gene expression

Sepsis can result when the body’s immune response to a specific infection gets out of control.

From University of California Santa Cruz 2 Feb 2021

3D genome study reveals molecular regulatory mechanisms of human brain evolution

A team led by Prof. SU Bing from the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences (CAS), Prof. LI Cheng from Peking University, and Prof. ZHANG Shihua from the Academy of Mathematics and Systems Science of CAS has reported the highest resolution by far of the 3D genome of the primate brain, and demonstrated the molecular regulatory mechanisms of human brain evolution through cross-species multi-omics analysis and experimental validation. The study was published in Cell.

29 Jan 2021

Study shows why obese mothers tend to have children susceptible to metabolic diseases

A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop the metabolic disease during their lifetime, as suggested by previous research.

27 Jan 2021

New computational tool can segment and analyze cell images of C. elegans

A joint research team co-led by City University of Hong Kong (CityU) has developed a novel computational tool that can reconstruct and visualise three-dimensional (3D) shapes and temporal changes of cells, speeding up the analysing process from hundreds of hours by hand to a few hours by the computer.

23 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Genetic predispositions affect the efficacy of COVID-19 drugs

A paper recently uploaded to bioRxiv* aimed to utilize genome-wide CRISPR screening to identify genes involved in modulating the activity of COVID-19 drugs.

29 Oct 2020

Researchers identify new potential therapeutic targets for SARS-CoV-2 infection

To identify new potential therapeutic targets for SARS-CoV-2, a team of scientists at the New York Genome Center, New York University, and the Icahn School of Medicine at Mount Sinai, performed a genome-scale, loss-of-function CRISPR screen to systematically knockout all genes in the human genome.

27 Oct 2020

Research focuses on understanding production of memory B cells and immune responses

The current COVID-19 climate has made vaccines, antibodies, and immune responses topics of everyday conversation. Now, it isn't just immunologists who want to know how our bodies respond to re-infections months, years, or sometimes decades after an initial immune response.

From Osaka University 13 Oct 2020

Study reveals how the loss of a protein affects proper brain development

Normal brain development requires a precise interplay between neuronal and non-neuronal (also called glial) cells. In a new study, researchers from the University of Tsukuba revealed how the loss of protein arginine methyltransferase (PRMT) 1 causes disruptions in glial cells and affects proper brain development.

24 Sep 2020

$1.2 million NIH grant awarded to create humanized mice susceptible to COVID-19

The National Institutes of Health has awarded a grant of $1.2 million to the Mouse Biology Program at the University of California, Davis, to create mice that are susceptible to the COVID-19 virus, and to distribute them to researchers.

11 Aug 2020

Study reveals new strategy to reduce tumor growth

According to a new study, tumors can escape the immune system by instructing immune cells to create immunosuppressive steroids.

31 Jul 2020

Discovering the Critical Role of Astrocytes in Neurodegenerative Diseases

AZoLifeSciences talks to Dr. Shane Liddelow about their research into discovering the critical role of astrocytes in neurodegenerative diseases like glaucoma.

From New York University (NYU) 29 Jul 2020

Golgi membrane protein drives growth and invasion of breast cancer

The cover for issue 28 of Oncotarget features Figure 5, "TMEM165 expression levels alters N-linked glycosylation," by Murali, et al., and reported that the TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry.

15 Jul 2020

Study shows how epigenetics contribute to the development of autoimmune diseases

The human immune system is expected to guard people against the invasion of external microbes, but at times, it possibly leads to autoimmune disorders.

From Osaka University 6 Jul 2020