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X-ray method helps track protein folding

Researchers from the Korea Advanced Institute of Science and Technology (KAIST) have employed an X-ray technique to monitor the mechanism of protein folding.

13 Jul 2020

Scientists report detailed proteomic analysis of human lung adenocarcinoma

A team of Chinese scientists from the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica under the Chinese Academy of Sciences, the State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, and Shanghai Jiao Tong University, recently reported a comprehensive proteomic analysis based on 103 Chinese patients with lung adenocarcinoma (LUAD), a leading cause of death among all types of cancer worldwide.

10 Jul 2020

New start-up to exploit novel drug-transporting technology

Researchers from IRB Barcelona, the University of Barcelona (UB) and the Sant Joan de Déu Research Institute - Hospital Sant Joan de Déu (SJD) have set up Gate2Brain, a company based on a novel technology developed at IRB Barcelona to transport drugs into the brain.

10 Jul 2020

Study: PINK1 and Parkin work together to induce selective autophagy

Researchers at TMIMS have revealed that PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins of damaged mitochondria to induce selective autophagy called mitophagy.

10 Jul 2020

Study shows sex hormones alter the behavior of non-sex organs

In one of the first studies addressing the role of sex hormones' impact on stem cells in the gut, scientists outline new insights showing how a steroidal sex hormone, that is structurally and functionally similar to human steroid hormones, drastically alters the way intestinal stem cells behave, ultimately affecting the overarching structure and function of this critical organ.

10 Jul 2020

Researchers use super-resolution microscopy to study close protein associations

With the advent of super-resolution microscopy, scientists can study close protein associations better than ever before.

10 Jul 2020

Single-nucleus RNA sequencing helps compare transcriptional responses to acute cocaine

The lab of Jeremy Day, Ph.D., at the University of Alabama at Birmingham, has used single-nucleus RNA sequencing approaches to compare transcriptional responses to acute cocaine in 16 unique cell populations from a portion of the brain called the nucleus accumbens, or NAc.

From University of Alabama 10 Jul 2020

Study explains why human mitochondrial genomes mutate frequently

One could say that mitochondria, the energy-producing organelles inside every human cell, dance to their own beat.

10 Jul 2020

TMEM106B gene reveals the causes of neurodegenerative diseases

Across the globe, approximately 50 million people are living with dementia. The two most common forms are Alzheimer's disease and frontotemporal lobar degeneration (FTLD), which develop when neurons in specific parts of the brain stop functioning - triggering memory loss and other behavioral or personality changes.

10 Jul 2020

Metabolomics can help understand the impact of calorie-restricted diets on aging

Changes in a few small molecules involved in a cell's metabolism seem to indicate whether a restricted "life extension" diet will actually extend, shorten, or have no effect on lifespan, a study of fruit flies has found.

10 Jul 2020

Study: Deep-sea microbes could have large amounts of available energy

Microbial cells are found in abundance in marine sediments beneath the ocean and make up a significant amount of the total microbial biomass on the planet.

10 Jul 2020

Bioinformaticians reveal previously unknown features of genes involved in brain functioning

In a recent study of genes involved in brain functioning, their previously unknown features have been uncovered by bioinformaticians from the Moscow Institute of Physics and Technology and the Institute of Mathematical Problems of Biology, RAS. The findings are reported in PLOS One.

10 Jul 2020

High concentrations of blood sodium can influence the biological clock of mice

A new study from McGill University shows that increases in the concentrations of blood sodium can have an influence on the biological clock of mice, opening new research avenues for potentially treating the negative effects associated with long-distance travel or shift work.

10 Jul 2020

Expansion stress promotes immunosuppression and enhances growth of breast cancer cells

Expansion stress can have an alarming impact on breast cancer cells by creating conditions that could lead to dangerous acceleration of the disease, an interdisciplinary team of University of Alabama at Birmingham researchers has found.

10 Jul 2020

Salmonella biofilm protein can cause autoimmunity and arthritis in animals

Scientists from the Vaccine and Infectious Disease Organization-International Vaccine Centre at the University of Saskatchewan and Temple University have demonstrated that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals.

10 Jul 2020

CU scientists identify key role of brain's immune cells during development

Researchers at the University of Colorado School of Medicine have identified how specific brain cells interacting during development could be related to neurological and neuropsychiatric diseases, including some that occur later in life.

10 Jul 2020

Preventing immune cell reprogramming could be a new way to stop breast cancer metastasis

Natural killer cells, a type of immune cell, are known to limit metastasis by inducing the death of cancer cells. But metastases still form in patients, so there must be ways for cancer cells to escape.

10 Jul 2020

ASC-enriched fat grafts for breast augmentation could produce superior results

Results of a clinical trial released today in STEM CELLS Translational Medicine indicates that breast augmentation in patients treated with fat grafts enriched with autologous adipose-derived stem cells (ASCs) had significantly superior results compared to those treated with non-enriched grafts.

9 Jul 2020

Supergenes may have a massive role in evolutionary adaption

Massive blocks of genes--inherited together 'plug and play' style--may play a larger role in evolutionary adaption than previously thought, according to new research in Nature.

9 Jul 2020

Research uncovers how 'reubiquitination' promotes elimination of misfolded membrane proteins

Chinese researchers recently discovered a protein quality control mechanism called "reubiquitination".

9 Jul 2020

Research News and Research

X-ray method helps track protein folding

Scientists report detailed proteomic analysis of human lung adenocarcinoma

New start-up to exploit novel drug-transporting technology

Study: PINK1 and Parkin work together to induce selective autophagy

Study shows sex hormones alter the behavior of non-sex organs

Researchers use super-resolution microscopy to study close protein associations

Single-nucleus RNA sequencing helps compare transcriptional responses to acute cocaine

Study explains why human mitochondrial genomes mutate frequently

TMEM106B gene reveals the causes of neurodegenerative diseases

Metabolomics can help understand the impact of calorie-restricted diets on aging

Study: Deep-sea microbes could have large amounts of available energy

Bioinformaticians reveal previously unknown features of genes involved in brain functioning

High concentrations of blood sodium can influence the biological clock of mice

Expansion stress promotes immunosuppression and enhances growth of breast cancer cells

Salmonella biofilm protein can cause autoimmunity and arthritis in animals

CU scientists identify key role of brain's immune cells during development

Preventing immune cell reprogramming could be a new way to stop breast cancer metastasis

ASC-enriched fat grafts for breast augmentation could produce superior results

Supergenes may have a massive role in evolutionary adaption

Research uncovers how 'reubiquitination' promotes elimination of misfolded membrane proteins

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