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Mechanisms of MCL-1 Inhibitor-Induced MCL-1 Protein Upregulation and Induction of Apoptosis

A new editorial paper was published in Oncotarget's Volume 14 on June 21, 2023, entitled, "Decoding the mechanism behind MCL-1 inhibitors: A pathway to understanding MCL-1 protein stability."

29 Jun 2023

Analyzing Glioma Progression and Implicating CPNs’ Long-Range Projections

Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor. Despite treatment, GBM recurrence is inevitable and tends to occur outside surgical margins or in locations remote to the primary tumor, highlighting the central role played by tumor infiltration in this malicious disease.

29 Jun 2023

New Breakthrough of Genetic Marker Improves Treatment for Multiple Sclerosis

A study of more than 22,000 people with multiple sclerosis has discovered the first genetic variant associated with faster disease progression, which can rob patients of their mobility and independence over time.

29 Jun 2023

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells.

29 Jun 2023

The Influence of Streptomyces on Soil Microorganisms

Chemical substances called arginoketides, which are produced by bacteria of the genus Streptomyces, cause a variety of reactions in other microorganisms: Algae group together to form aggregates, fungi produce signaling molecules that they would not otherwise produce, and bacteria develop biofilms that cause other organisms to respond differently.

28 Jun 2023

Cell Fate Conversion Plays Crucial Role in Cancer Research

Researchers from the Max Delbrück Center for Molecular Medicine in the Helmholtz Association in Berlin and the Centre for Genomic Regulation (CRG) in Barcelona have discovered how cells speed changes to their identity known as “cell fate conversion.”

28 Jun 2023

Probiotic Bacteria may Help Maintain Brain Function in Aging Nematodes

A group from Nagoya University in Japan has discovered that when the diet of nematodes, tiny worms measuring about a millimeter or less in length, includes the bacteria Lactobacillus reuteri, the weakening of associative learning ability caused by aging does not occur.

28 Jun 2023

Discovering a Major Factor Causing Aggressive Cancer

Researchers from the University of Otago have identified a crucial factor that contributes to the aggressive spread of colon cancer, marking a significant advancement in the fight against fatal tumors.

27 Jun 2023

New Computational Methods for Improving Alzheimer’s Disease Characterization

An improved method of subtyping Alzheimer’s disease based on genetic and tau PET imaging data has been developed computationally.

27 Jun 2023

Analyzing the Cis-Regulatory Elements and Transcription Factors Related to Auxin Signaling

Phytohormones are chemical messengers that control the growth of plants and also their response to the environment.

27 Jun 2023

Novel Drug Slows Development of Antibiotic Resistance

At the Baylor College of Medicine, a research group is gaining ground in its quest for solutions to the global concern of bacterial antibiotic resistance, which was accountable for almost 1.3 million deaths in 2019.

26 Jun 2023

Location-Dependent Gene Expression in Ovarian Cancer: Insights from 3-D Models

Variations in gene activity based on where a cell is in a tumor have been discovered by researchers with the help of 3-D models of ovarian cancer tumors.

26 Jun 2023

The Method by Which Plants Prevent Cracking Under Growth Stress

An obscure aquatic plant has helped to explain how plants avoid cracking up under the stresses and strains of growth.

23 Jun 2023

Immune Deficits in Space are Temporary

An increase in proof has been found that astronauts are highly vulnerable to infections while in space. For instance, astronauts on board the International Space Station (ISS) generally suffer from skin rashes, and also respiratory and non-respiratory diseases.

23 Jun 2023

The Asgard Connection: New Research Uncovers the Origins of Complex Life

Thor, the legendary Norse god from the mythological city of Asgard, is not alone. According to groundbreaking research published in the journal Nature, we humans -; along with eagles, starfish, daisies and every complex organism on Earth -; are, in a sense, Asgardians.

23 Jun 2023

TTUHSC and TTU Researchers Uncover Promising Leads in the Fight Against Leishmaniasis

Leishmaniasis is a tropical disease caused by parasites known as Leishmania, which are transmitted to humans and animals through the bites of more than 90 species of sand flies.

23 Jun 2023

New Genetic Marker Could Predict Lenvatinib Resistance in Hepatocellular Carcinoma

A genetic marker discovered by UT Southwestern Medical Center researchers could help physicians predict which patients with hepatocellular carcinoma are most likely to develop resistance to the drug lenvatinib.

23 Jun 2023

New Approach to Revolutionize Synthetic Biology

For the first time, scientists at the Lawrence Berkeley National Laboratory of the Department of Energy (Berkeley Lab) have created a genome-scale method to map the regulatory role of transcription factors, proteins that are essential for controlling gene expression, and a plant’s physiological features.

22 Jun 2023

Loss of the Y Chromosome Impairs Body's Ability to Fight Cancer

According to recent Cedars-Sinai Cancer research, as men age, some of their cells lose the very feature that makes them biological males—the Y chromosome—and this loss impairs the body’s ability to fight cancer.

22 Jun 2023

Cells with “Jumping Genes” Self-Destruct in the Early Stages of Development

A previously unknown type of cell that self-destructs within days of forming as part of a quality control procedure to protect the growing fetus has been found by researchers studying gene activity data of the early human embryo.

21 Jun 2023