Biochemistry News and Research

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Bridge RNA: The Revolutionary Tool in Genetic Recombination

In a leap forward for genetic engineering, a team of researchers from the Arc Institute have discovered the bridge recombinase mechanism, a precise and powerful tool to recombine and rearrange DNA in a programmable way.

27 Jun 2024

AI-Driven Design of Soluble Protein Analogs for Drug Discovery and Antibody Development

Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter cellular behavior.

24 Jun 2024

New Cold-Sensing Protein Discovery Could Revolutionize Pain Management

The only available treatments for millions of people with chronic pain worldwide frequently involve the use of opioids, which pose the risk of addiction and overdose.

24 Jun 2024

Breakthrough Imaging Reveals the Dynamics of the Brain's Fast-Acting Kainate Receptor

New groundbreaking images of one of the brain's fastest-acting proteins are providing critical clues that may lead to the development of targeted therapies to treat epilepsy and other brain disorders.

18 Jun 2024

Simplified Proteomics Method Could Open the Door Toward Precision Medicine

Proteins are workhorses that carry out most of the biological functions in our cells.

12 Jun 2024

Multiciliated Cell Differentiation Regulated by an Alternative Cell Cycle

A fertilized egg can develop into a baby through the amazing process of cell division, while a malignant cell can become a malignant tumor. Since there is so much on the line, nature maintains strict control over it through a mechanism known as the cell cycle that scientists once believed they thoroughly understood.

7 Jun 2024

Novel Lipopeptide from Serratia marcescens Shows Promise Against Staphylococcus aureus Infections

A novel antibacterial lipopeptide produced by the bacterium Serratia marcescens has been shown to be highly effective in killing Staphylococcus aureus – one of the most important pathogens occurring in humans.

7 Jun 2024

Study Unveils Key Mechanism of Telomere Maintenance by CST–Polα/Primase

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, resulting in telomere disorders with serious health consequences.

6 Jun 2024

UC San Diego Researchers Find Cause of Cellular 'Short-Circuit'

A group of researchers at University of California San Diego has identified the cause of a "short-circuit" in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.

5 Jun 2024

Researchers Advance Single-Molecule DNA Sequencing Techniques

In recent years, technologies that allow scientists to investigate a person's DNA at single-molecule resolution have greatly increased the knowledge of the human genome, microbiome, and the genetic basis of disease.

5 Jun 2024

Brain Organoids Emerge as Powerful Tool for Drug Discovery in Mitochondrial Disease

The use of brain organoids in screening for drugs against mitochondrial diseases, which have hitherto presented challenges in treatment.

4 Jun 2024

RNAConnect, Inc. Formally Launched to Drive RNA Analysis

RNAConnect, a pioneering life science reagent company, officially launches today, promising groundbreaking solutions for exploring the real-world diversity of RNA sequence and structure.

From RNA Connect 29 May 2024

Multiplexed Orthogonal Base Editors for Precise Mutation Modeling

The human genome consists of around 3 billion base pairs and humans are all 99.6% identical in their genetic makeup.

23 May 2024

Air-Dried Soil Archives Proven Viable for Long-Term Microbial Community Analysis

Post-doctoral researcher Joe Edwards and graduate student Sarah Love, both in the Department of Ecology and Evolutionary Biology, published findings this spring that can save fellow researchers a lot of time and energy when storing soil samples for later study of their microbial content.

21 May 2024

Breakthrough in Natural Vanillin Production Using Engineered Enzyme

Vanilla extract is one of the most widely used flavoring compounds in food products and cosmetics.

17 May 2024

Glycosylation and its Role in Human Health and Disease

The current understanding of glycosylation genetics in mammals and the consequences of mutations that impact glycosylation.

16 May 2024

Targeting RNA Modifications: A Novel Approach for Neuroblastoma Treatment

Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain.

6 May 2024

Protein Complex Movement May Regulate Cell Division, Impacting Disease Research

Scientists at Umeå University in Sweden have found that the movement of a unique protein complex known as the Mediator along DNA genes may affect the process of cell division.

6 May 2024

Understanding How Genetic Drivers Influence the Evolution of Photosynthesis Mechanism in Tillandsia

Researchers at the University of Vienna, along with collaborators from France, Germany, Switzerland and the USA, have achieved a major breakthrough in understanding how genetic drivers influence the evolution of a specific photosynthesis mechanism in Tillandsia (air plants).

2 May 2024

Unlocking Brown Fat's Potential: Study Reveals Key Protein in Obesity Regulation

Brown fat, also known as brown adipose tissue (BAT), is a type of fat in our bodies that's different from the white fat around our belly and thighs that we are more familiar with.

30 Apr 2024