Biomedicine News and Research

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Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.

2 Dec 2021

Researchers show that tumor cells contribute differently to the formation of metastases

A type of cell transformation known as EMT enables cancer cells to break away from the tumor and form metastases elsewhere.

30 Nov 2021

Researchers expand understanding of how T cells recognize infections or disease

T cells communicate with other cells in the body in search of infections or diseases. This crosstalk relies on specialized receptors known as T cell receptors that recognize foreign molecular fragments from an infection or cancer that are presented for detection by particular molecules called major histocompatibility complex (MHC) or MHC-like.

23 Nov 2021

Research demonstrates how diet affects immunity through the gut microbiome

The cliché "you are what you eat" has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.

From Harvard Medical School 17 Nov 2021

Apoptosis of mesenchymal stromal cells benefits therapeutic function

Scientists recently identified the therapeutic benefits to patients receiving mesenchymal stromal cell (MSC) therapy.

15 Nov 2021

Novel technique enhances the predictability of protein manufacturing

Researchers from VIB and Ghent University devised a new technique to analyze the secretability of hundreds of thousands of protein sequences at once.

10 Nov 2021

Researchers employ hepatic organoids for disease modeling

Associate Professor Tamer Önder created and analyzed the hepatic organoid culture system utilizing human induced pluripotent stem cell as an intermediate.

8 Nov 2021

Researchers propose novel model for mitochondrial nucleoid self-assembly

Mitochondria, the powerhouse of mammalian cells, also perform vital roles in cell signaling, cell metabolism, and apoptosis.

8 Nov 2021

Earlier known protein complex acts as a centriole stabilizer, says study

Microtubules are fibers in cells that construct a network to offer shape and structure to cells along with mediating transport mechanisms.

4 Nov 2021

CHOP-led network aims to unlock the genetic mysteries behind pediatric brain tumors

Unlocking the genetic mysteries behind pediatric brain tumors is at the heart of the mission of the Center for Data Driven Discovery in Biomedicine (D3b) at Children's Hospital of Philadelphia.

3 Nov 2021

Scientists identify genes responsible for allowing Candida fungus to survive treatment

It is estimated that 80% of women will suffer from vaginal candidiasis at least once in their lives. In addition to superficial infections, which can be oral or vaginal and do not usually have a serious prognosis, fungi of the Candida genus can cause systemic diseases in immunocompromised individuals and these are fatal in 40% of cases.

26 Oct 2021

Mitochondrial inner membrane fusion protein acts as a molecular chaperone

Cells contain numerous functional “micro-organs” known as organelles. Mitochondria, the “power plant” of the cell, are the energy-producing organelles.

25 Oct 2021

Creating Protein Songs Using Classical Music

AZoLifeSciences speaks to researchers about their latest protein research, and how protein songs can be created from classical music.

From National University of Singapore (NUS) 7 Oct 2021

Study sheds light on the genetic toolkit used during evolution to create different extremities

A sophisticated system guides the development of our limbs. Researchers at University of Basel have shed new light on the genetic toolkit used during evolution to create a range of different extremities such as fins, wings, hooves, toes and fingers.

30 Sep 2021

Master regulator behind the development of antibody-producing cells identified

Scientists from Weill Cornell Medicine recently found the master regulator behind the development of antibody-creating cells.

27 Sep 2021

New approach to identify molecular targets for improved prostate cancer therapy

In a new study, researchers have introduced DSER, a technique for identifying molecular targets for enhanced therapy in prostate cancer.

14 Sep 2021

Study identifies C9orf72 repeat expansion using novel genetic marker

Research offers a new genetic tool to pinpoint C9orf72 repeat expansion-carrying frontotemporal lobar degeneration from huge population-based cohorts.

25 Aug 2021

Study shows how T cells become activated when encountering pathogens

Researchers from Monash University have made a significant breakthrough relating to how T cells get activated when exposed to pathogens, like viruses.

9 Jun 2021

Study describes the impact of DNA methylation on the 3D structure of genome

Although all cells in an organism share the same DNA sequence, their shapes, roles, and even lifespans differ drastically.

4 Jun 2021

Scientists discover the central role of LRRC8A gene in cellular ability to survive osmotic shock

Cells have to constantly adapt to their surroundings in order to survive. A sudden increase in the environmental levels of an osmolyte, such as salt, causes cells to lose water and shrink. In a matter of seconds, they activate a mechanism that allows them to recover their initial water volume and avoid dying.

2 Jun 2021