Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Toxic Plant Toxin Gets a Safety Upgrade for New Drugs and Pesticides

Picrotoxinin, a plant-derived toxin that Asian fishermen traditionally have used to paralyze and catch fish, has long been seen as a possible starting point for new human therapeutics and other neuroactive products.

26 Dec 2023

Innovative Machine Learning Tool Predicts Functional Consequences of Genetic Variants

In a recent research, scientists from the Icahn School of Medicine at Mount Sinai unveiled LoGoFunc, an innovative computational tool designed to forecast both pathogenic gain- and loss-of-function variants throughout the genome.

15 Dec 2023

Understudied Brain Cell Holds Key to Glioblastoma's Immunotherapy Resistance

Glioblastoma is one of the most treatment-resistant cancers, with those diagnosed surviving for less than two years.

13 Dec 2023

Free AI Drug Discovery Course Surpasses 2,500 Users

An online course on Disease Modeling and Target Discovery launched 7 months ago by clinical stage generative artificial intelligence (AI)-driven biotechnology company Insilico Medicine has surpassed 2,500 users.

12 Dec 2023

SFU-UBC Collaboration Pushes Frontiers of Cellular Biology With AI-Enhanced Super-Resolution Microscopy

In 2014, the Nobel Prize in Chemistry celebrated the breakthroughs in super-resolution microscopy, a technology that allows us to capture highly detailed images of small parts of cells using fluorescent microscopy.

11 Dec 2023

Camena Bioscience Appoints Dr. Nicola Thompson as Chair of the Board

Camena Bioscience, a synthetic biology company providing genes to the pharmaceutical and biotechnology industries, today announced it has appointed Dr Nicola Thompson as Chair of its Board of Directors.

From Camena Bioscience 6 Dec 2023

Algorithmiq Demonstrates Path to Quantum Utility with IBM

Algorithmiq, a scaleup developing quantum algorithms to solve the most complex problems in life sciences, has successfully run one of the largest scale error mitigation experiments to date on IBM’s hardware.

6 Dec 2023

Discovery Park Ventures Expands Fund to £3m to Invest in More Innovative Science and Technology Start-Ups

Discovery Park Ventures (DPV) announces the expansion of its early-stage life science fund from £1m to £3m, in order to capitalise on exciting investment opportunities and support its existing portfolio.

5 Dec 2023

Could A Small Flower Hold The Key to More Stable Peptide Drugs?

Taking inspiration from a small purple flower found in the tropics, University of Bath scientists have successfully created a new tool that could help to create more stable, efficient and cost-effective drugs.

29 Nov 2023

New £100 Million Fund to Capitalise on AI’s Game-Changing Potential in Life Sciences and Healthcare

A new mission announced by the Prime Minister will accelerate the use of AI in life sciences to tackle the biggest health challenges of our generation.

30 Oct 2023

Revolutionizing Drug Discovery: The Role of AI in Lead Optimization

Lead optimization in the field of drug discovery poses a formidable challenge, predominantly hinging on conjectures and the expertise of medicinal chemists.

25 Oct 2023

BioLizard Launches New AI-Empowered “BioVerse” Platform to Facilitate Data-Driven R&D for Global Life Sciences Community

BioLizard, the bioinformatics, data analytics and data management service and consulting company heading digital transformation in the life sciences industry, today announced the launch of its new BioVerse platform.

11 Oct 2023

Targeted MicroRNA-34a Therapy Shows Promise in Slowing Tumor Growth in Mice

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division.

5 Sep 2023

Scale Biosciences Continues Commercial Expansion with Introduction of New and Differentiated Single Cell Methylation and Single Cell RNA Sequencing Solutions

Scale Biosciences, Inc. (ScaleBioTM), an innovator in single cell sequencing leveraging combinatorial indexing technologies, today announced an expansion of their product portfolio to enable a broader range of single cell omics experiments and unlock new translational research applications.

30 Aug 2023

Study Identifies 39 Genetic Mutations Associated With Heart Failure

In a new study co-led by investigators at the United States Department of Veterans Affairs and Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, a global team of scientists conducted one of the largest genetic association studies on heart failure to date.

25 Aug 2023

Innovative Method Accelerates Discovery of New Drugs by Harnessing the Power of Ribosomes

A research team led by University of California, Irvine scientists has developed an innovative method for quickly and efficiently creating vast collections of chemical compounds used in drug discovery by harnessing the power of ribosomes, the molecules found in all cells that synthesize proteins and peptides.

24 Aug 2023

From Neanderthals to New Drugs: Unlocking Ancient Proteins

We need to think big in antibiotics research.

17 Aug 2023

Discovering Age and Sex-Specific Obesity Genes in the Genome

Right from impacting how the human body stores fat to how the brain regulates appetite, hundreds of genes, together with environmental factors, jointly identify weight and body size.

3 Aug 2023

New Breakthrough in Generative AI Models and AlphaFold Structures for Drug Discovery

Insilico Medicine ("Insilico"), a clinical-stage end-to-end generative artificial intelligence (AI) drug discovery company, has achieved a significant breakthrough in the application of multiple generative AI models and AlphaFold structures for drug discovery.