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DNA Methylation Governs Citric Acid Production in Lemons

Lemons owe their signature tang to citric acid, yet the molecular mechanisms governing its accumulation have long remained a mystery.

12 Feb 2025

Scientists Discover Hidden Role of RNA Introns in Cellular Stress Response

Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing production of certain messenger RNAs and appear to help cells respond to oxidative stress.

12 Feb 2025

Mismatch Repair Genes Found to be Key Drivers of Huntington's Disease

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream pathologies and motor impairment, shedding light on disease mechanisms and potential new ways to develop therapies.

12 Feb 2025

Researchers Uncover Genomic Drivers Behind Aggressive Breast Cancer

Breast cancers can be classified into subgroups that hint at the aggressiveness of the cancer and the likelihood that the patient will experience a recurrence years after their initial diagnosis.

11 Feb 2025

Researchers Cultivate an Ultrasmall Bacterial Strain Parasitizing Archaea

AIST researchers, in collaboration with JAMSTEC, Hokkaido University and Tohoku University, have succeeded in cultivating an ultrasmall bacterial strain parasitizing archaea and classified the strain PMX.108T as new species and genus of Minisyncoccus archaeiphilus.

11 Feb 2025

Study Uncovers Immune Cell Interaction Driving Aggressive Brain Tumor Growth

A type of aggressive, treatment-resistant brain tumor has a distinct population of immune cells that support its growth, according to new research led by investigators at the Johns Hopkins Kimmel Cancer Center Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins University School of Medicine.

11 Feb 2025

Novel Biorecycling Method Transforms Nylon Waste into Bioplastics

A group of researchers from the Institute of Bio- and Geosciences – Biotechnology at Forschungszentrum Jülich, in collaboration with the company Novonesis, has successfully engineered a bacterium capable of “eating” individual building blocks of various types of nylon and converting them into value-added products.

11 Feb 2025

High-Resolution Images Reveal How Cells Discard Faulty Spliceosomes

A sophisticated molecular machine, the spliceosome, ensures the accurate assembly of genetic information from the genome into mature mRNA after it has been transcribed into mRNA precursors.

10 Feb 2025

The Antibiotic Arms Race: Can Science Stay Ahead of Rapidly Evolving Antibiotic-Resistant Bacteria?

A study reveals alarming rates of antibiotic resistance in Gram-negative bacteria, highlighting the urgent need for innovative strategies to combat this crisis.

10 Feb 2025

Genetic Editing Reveals Key Functions of Bean Plant Genes in Nitrogen Fixation

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume.

8 Feb 2025

New Gene Map Reveals Potential Drug Targets for Malaria Treatment

Researchers at Harvard T.H. Chan School of Public Health and their collaborators have created a comprehensive map of all the genes essential for blood infections in Plasmodium knowlesi, a parasite that causes malaria in humans.

7 Feb 2025

New CRISPR Tool Reveals Key Lymphoma Genes

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

7 Feb 2025

Scientists Decode Migration Patterns of Painted Lady Butterflies

Painted lady butterflies are world travelers. The ones we encounter in Europe fly from Africa to Sweden, ultimately returning to areas north and south of the Sahara.

5 Feb 2025

Genetic Map of Yerba Mate Offers Insight into Evolution of Caffeine Biosynthesis

Yerba mate, along with tea and coffee, is one of the world's most popular caffeinated beverages. Widely consumed in South America, this remarkable plant is rich in diverse, bioactive compounds that contribute many health benefits.

5 Feb 2025

Exploring Chromatin's Resilience to Develop Anti-Aging Strategies

The process of aging in the body may be more resilient than previously believed, according to a new study.

4 Feb 2025

Generative AI Decodes the 3D Structure of DNA

Although the genetic sequence is the same in every cell in the body, only a subset of those genes is expressed by each cell.

3 Feb 2025

Scientists Design Ultra-Stable Synthetic Proteins That Could Change Drug Discovery

Innovative designs of GPCRs with enhanced signaling and stability offer new insights for drug discovery and synthetic biology, transforming protein engineering.

3 Feb 2025

Random Versions of Human Genomes Created to Unlock Disease Mechanisms

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

3 Feb 2025

First Cell Atlas of Focal Cortical Dysplasia Offers New Insights for Treatment

Using a single-cell sequencing technique, Brazilian researchers have created the first cell atlas of focal cortical dysplasia (FCD), a malformation of the cerebral cortex that leads to drug-resistant epilepsy.

31 Jan 2025

Research Paves Way for Off-the-Shelf CAR T Cells for Cancer Treatment

CAR T cell therapy is one of the most promising new cancer treatments to emerge in recent years. It involves removing a patient's own immune T cells and engineering them to recognize specific targets on the surface of the cancer cell.

31 Jan 2025