Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

3D “mini eyes” provide insight into genetically induced blindness

The development of “mini eyes” by researchers at the UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) has made it possible to study and comprehend the onset of blindness in the rare genetic disease known as Usher syndrome more.

From University College London 22 Nov 2022

New guidelines to generate high-quality, well-structured organoids

Researchers have opened a new avenue for investigations of neurological development, disease, and therapies that cannot be undertaken in living people by employing stem cells to grow small brain-like structures in the lab.

30 Sep 2022

Researchers reveal key developmental difference between the brains of modern humans and Neanderthals

AZoLifesciences speaks to Dr. Anneline Pinson and Prof. Dr. Wieland B. Huttner from The Max Planck Institute of Molecular Cell Biology and Genetics about their latest research which found a greater neuron production in the frontal lobe during brain development in modern humans than Neanderthals, due to the change of a single amino acid in the protein TKTL1.

From The Max Planck Institute 20 Sep 2022

Human-specific gene involves in neocortical expansion during evolution

Great ape animal experiments have long been prohibited in Europe due to ethical concerns. An alternative to using animals in investigations is the use of organoids, which are three-dimensional cell structures that can be generated in the lab and are only a few millimeters in size.

From The Max Planck Institute 14 Sep 2022

Engineers develop the world's smallest EEG caps for mini brains

It could be the world's tiniest EEG electrode cap, created to measure activity in a brain model the size of a pen dot. Its designers expect the device to lead to better understanding of neural disorders and how potentially dangerous chemicals affect the brain.

18 Aug 2022

Scientists develop microscopy technology that observes how new neurons struggle to reach their developmental destination

With organoids to model early growth, scientists employed a developing microscopy technology to observe that new neurons find it hard to reach their developmental goal.

From Massachusetts Institute of Technology (MIT) 1 Aug 2022

How can High-Content Screening accelerate Drug Discovery?

As part of our SLAS Europe 2022 coverage, we speak to Professor Jeremy Simpson from the University College Dublin about the role high-content screening can play in accelerating drug discovery.

From Society for Laboratory Automation and Screening (SLAS) 6 Jul 2022

Researchers demonstrate a possible new way of generating insulin-producing cells

Researchers at Karolinska Institutet in Sweden show how a molecule that they have identified stimulates the formation of new insulin-producing cells in zebrafish and mammalian tissue, through a newly described mechanism for regulating protein synthesis.

14 Jun 2022

Researchers analyze functional microglia to empower retinal organ

Professor Zi-Bing Jin is in charge of this research (Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, and Capital Medical University). He has spent the last decade working on retinal organoids, which can accurately mimic retinal development.

3 Jun 2022

Scientists demonstrate how stomach stem cells switch from one state to the other upon injury

A stomach adult stem cell population can fulfill two distinct functions: either help with digestion under normal conditions or take the lead on injury response. S

26 May 2022

Research sheds light on new options for organ cultivation in vitro

How do human cells organize themselves to give the organs their ultimate shape? The solution is morphogenesis, a collection of systems that controls their spatial distribution throughout embryonic development. In this sector, a team from the University of Geneva (UNIGE) recently discovered an unexpected discovery: when a tissue curves, the volume of the cells that makes it up grows rather than decreases.

18 May 2022

Scientists reveal how autism-linked genetic mutation disrupts neural development using mini-brains

In a study published May 02, 2022 in Nature Communications, scientists at University of California San Diego School of Medicine used human brain organoids to reveal how a genetic mutation associated with a profound form of autism disrupts neural development.

From UC San Diego 3 May 2022

Combining organoids and microfluidics to study how the immune system responds to hepatitis C

A vaccine for hepatitis C has eluded scientists for more than 30 years, for several reasons. For one, the virus that causes the disease comes in many genetic forms, complicating the creation of a widely effective vaccine.

7 Apr 2022

Intestinal cell changes are driven by the BMP signaling pathway, study finds

Intestinal cells can change specializations during their lives. The BMP signaling pathway – an important communication mechanism between cells – appears to be the driver of these changes.

2 Mar 2022

Scientists elucidate mechanism that causes treatment resistance in aggressive pancreatic cancer

Drug resistance is a major obstacle in the treatment of cancers. In an aggressive type of pancreatic cancer, for instance, drug resistance is associated with the suppression of programmed cell death, which results in the uncontrolled growth of cancer cells.

25 Feb 2022

Organoids News and Research

3D “mini eyes” provide insight into genetically induced blindness

New guidelines to generate high-quality, well-structured organoids

Researchers reveal key developmental difference between the brains of modern humans and Neanderthals

Human-specific gene involves in neocortical expansion during evolution

Engineers develop the world's smallest EEG caps for mini brains

Scientists develop microscopy technology that observes how new neurons struggle to reach their developmental destination

How can High-Content Screening accelerate Drug Discovery?

Researchers demonstrate a possible new way of generating insulin-producing cells

Researchers analyze functional microglia to empower retinal organ

Scientists demonstrate how stomach stem cells switch from one state to the other upon injury

Research sheds light on new options for organ cultivation in vitro

Scientists reveal how autism-linked genetic mutation disrupts neural development using mini-brains

Combining organoids and microfluidics to study how the immune system responds to hepatitis C

Intestinal cell changes are driven by the BMP signaling pathway, study finds

Scientists elucidate mechanism that causes treatment resistance in aggressive pancreatic cancer

Chlamydia and HPV co-infection causes a unique cellular reprogramming, study shows

Human nose organoids reveal the first events of SARS-CoV-2 and RSV infection

Researchers discover DisCo for effective processing of samples with fewer cells

Infusion of intestinal organoids to replace damaged intestinal tissue

Different autism risk genes have similar effects on brain development, study finds

eBook: Essential Guide to Organoids for Drug Discovery Applications eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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