therapeutics News and Research

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De Novo Antibody Protein Sequencing Reveals Novel Functional and Neutralizing Antibodies Post-SARS-CoV-2 Vaccination

Rapid Novor has published a study that highlights the power of combining de novo antibody protein sequencing with conventional proteomics to uncover functional and neutralizing antibodies in human plasma following SARS-CoV-2 vaccination.

From Rapid Novor Inc 14 Oct 2024

New Approach Aims to Enhance CRISPR Safety and Precision

CRISPR is a revolutionary tool that allows scientists to precisely modify the genome and gene expression of cells in any organism.

8 Oct 2024

New Tool START Enables Precision Mapping of Neuronal Connectivity

Scientists at the Salk Institute are unveiling a new brain-mapping neurotechnology called Single Transcriptome Assisted Rabies Tracing (START). The cutting-edge tool combines two advanced technologies-;monosynaptic rabies virus tracing and single-cell transcriptomics-;to map the brain's intricate neuronal connections with unparalleled precision.

1 Oct 2024

Stem Cell Study Reveals Developmental Dance Behind Individual Variation

Researchers at the Johns Hopkins University School of Medicine have conducted a comprehensive analysis of the variations present in human stem cells. This study sheds light on how the unique “developmental dance” at the molecular level within an individual's cells can shape the formation of the brain and the body.

26 Sep 2024

High-throughput screening identifies potential drugs for low-grade serous ovarian cancer

In a recent study, researchers used high-throughput drug screening to identify potential therapeutic targets and novel treatments for low-grade serous ovarian cancer (LGSOC), offering hope for more effective and personalized therapies.

26 Sep 2024

A Novel Function for STING in DNA Damage Response

A study published in the journal Molecular Cell has shed light on the multifaceted role of STING, a protein previously implicated in antiviral signaling pathways. The study reveals that STING also plays a crucial part in facilitating cellular stress resolution and promoting cell survival.

23 Sep 2024

AI-Driven Insights into Lasso Peptide Biosynthesis

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, published in Nature Chemical Biology, researchers have constructed and tested models for how these peptides are made and demonstrated how this information might be used to advance lasso peptide-based drugs into the clinic.

23 Sep 2024

Harnessing the Power of Beneficial Bacteria to Fight Enterobacteriaceae

Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time. Gram-negative bacteria such as Enterobacteriaceae are a common cause of these infections and have few treatment options. Fecal microbiota transplants have shown promise to curb some of these infections, but their composition varies between batches and they aren't always successful.

23 Sep 2024

Low Extracellular Sodium Concentrations Can Suppress mRNA Expression in Brain Cells

Brain and mental problems can result from chronic hyponatremia, a disorder marked by low blood salt levels.

19 Sep 2024

New study highlights the medicinal potential of plants consumed by gorillas

In a recent study, researchers examined the antibacterial and antioxidant properties of plants used by western lowland gorillas for self-medication, highlighting the potential of these bioactive compounds for therapeutic applications in human medicine.

19 Sep 2024

One-Third of Antibody Drugs Show Unintended Target Binding

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Lipids Found to Play Key Role in Cancer Immune Evasion

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes.

18 Sep 2024

Breakthrough Discovery on How TGF-Beta Communicates in Cells

Scientists discover how TGF-Beta, a crucial protein in development and cancer, sends its message even while tethered to the cell membrane.

17 Sep 2024

Innovative Approach Supercharges T Cells by Transferring Healthy Mitochondria

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion.

16 Sep 2024

Decoding the Infant Microbiome's Three Pioneers

Researchers discovered that newborn newborns had one of three pioneer bacteria in their stomach immediately after birth, one of which might be exploited to generate novel personalized infant therapeutic probiotics.

9 Sep 2024

Rice Researchers Map Protein Interactions for Creating Functional Gas Vesicles

As far as water gear goes, floaties are not exactly high tech. But the tiny air-filled bubbles some microorganisms use as flotation devices when they compete for light on the water surface are a different story.

4 Sep 2024

New AI Tool Deciphers Cellular Metabolism

Biology depends on humans' ability to comprehend metabolism, the process by which cells use resources and create energy.

2 Sep 2024

A Landmark Study Reveals the Widespread Existence of DNA i-Motifs

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

30 Aug 2024

Evolution of Blood Sugar Regulation in Neotropical Bats

Humans must regulate blood sugar concentrations to stay healthy and to fuel our cells. Too little or too much can cause serious health complications, and high blood sugar is a hallmark of the metabolic condition, diabetes. New research from the Stowers Institute for Medical Research may enable potential solutions to metabolic disease by turning to evolution and to bats.

29 Aug 2024

RNA Interference Drugs Offer Faster, More Effective Alternative to Traditional Drug Discovery

Alnylam's RNA interference platform accelerates drug discovery by targeting RNA transcripts, addressing complex diseases with innovative therapeutic strategies.

28 Aug 2024