Cancer News and Research

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Cancer begins in your cells, which are the building blocks of your body. Normally, your body forms new cells as you need them, replacing old cells that die. Sometimes this process goes wrong. New cells grow even when you don't need them, and old cells don't die when they should. These extra cells can form a mass called a tumor. Tumors can be benign or malignant. Benign tumors aren't cancer while malignant ones are. Cells from malignant tumors can invade nearby tissues. They can also break away and spread to other parts of the body.

Study discovers the ability of certain blood immune cells to proliferate

The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell.

20 Mar 2023

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR. The human body has more than 800 types of GPCRs that provide cells with information about the external environment to calibrate responses.

20 Mar 2023

Immune landscape in invasive ER+ breast cancers reveals a macrophage-driven microenvironment

Most immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer.

20 Mar 2023

New combination therapy regimen may reduce prostate cancer progression or death by 37%

TALAPRO-2, a study led by Neeraj Agarwal, MD, FASCO, demonstrated that using TALZENNA, in combination with XTANDI, may reduce the risk of disease progression or death by 37%.

20 Mar 2023

Cancer cells use new DNA repair mechanism to recover from next-generation cancer radiation therapy

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover from next-generation cancer radiation therapy.

20 Mar 2023

Delaying paralysis in ALS by using designer DNA drug

In virtually all persons with amyotrophic lateral sclerosis (ALS) and in up to half of all cases of Alzheimer's disease (AD) and frontotemporal dementia, a protein called TDP-43 is lost from its normal location in the nucleus of the cell.

20 Mar 2023

Neoadjuvant dual immunotherapy and chemotherapy improve outcomes in patients with resectable NSCLC

In a Phase II trial led by researchers from The University of Texas MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC).

20 Mar 2023

Using a programmable control switch to deliver therapeutic RNA molecules to target cells

Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene.

17 Mar 2023

Potential approach to improve solid tumor T cell therapy

Researchers at the Perelman School of Medicine at the University of Pennsylvania have been working on a preclinical study that focuses on a new strategy that uses a “one-two punch” to assist T cells in attacking solid tumors.

17 Mar 2023

The impact of genome doubling on the development of cancer

Since a single cell has 2–3 m of DNA, the only method to store it is in tight coils. The answer is chromatin, a DNA-protein complex that is wrapped around histone proteins.

17 Mar 2023

Highlighting a potential sex‐specific precision immunotherapy strategy

Immunotherapy is an effective form of treatment for various types of cancer. However, its effect on pancreatic cancer is restricted and varies between men and women. Karolinska Institutet scientists have observed a possible explanation for this gender difference.

17 Mar 2023

Using PET and electron microscopy to generate 3D maps of mitochondrial networks in lung tumors

Scientists have long known that mitochondria, the "powerhouses" of cells, play a crucial role in the metabolism and energy production of cancer cells.

16 Mar 2023

High doses of sucralose limit T cell proliferation and differentiation

Scientists at the Francis Crick Institute have found that high consumption of a common artificial sweetener, sucralose, lowers activation of T-cells, an important component of the immune system, in mice.

16 Mar 2023

First molecular images of olfaction sets the stage to create novel smells

Breaking a longstanding impasse in our understanding of olfaction, scientists at UC San Francisco (UCSF) have created the first molecular-level, 3D picture of how an odor molecule activates a human odorant receptor, a crucial step in deciphering the sense of smell.

16 Mar 2023

Study examines the role of dietary vitamin A in preventing or treating AAP

Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment.

16 Mar 2023

Age-related sarcopenia prevented by AAV1.NT-3 gene therapy

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "AAV1.NT-3 gene therapy prevents age-related sarcopenia."

16 Mar 2023

Aston University receives funding for the development of a diagnostic tool for children with brain tumors

Birmingham based charity, Help Harry Help Others and Aston University researchers, are working together to develop a pioneering pre-surgical diagnostic tool, which could see the eventual outcome of children with brain tumors drastically improve.

15 Mar 2023

High correlation between the product of a gene in the majority of cancers

The product of a gene expressed in most cancers, including the most prevalent type of head and neck cancer, has been linked to elevated levels of white blood cells that produce antibodies inside tumors, according to researchers at the University of California San Diego School of Medicine and UC San Diego Moores Cancer Center.

14 Mar 2023

Rice biologists embark on a three-year project to create genetically encoded antibiotics

Synthetic biologists at Rice University are embarking on a three-year project to create "genetically encoded antibiotics," strands of RNA that bacteria will readily copy and share that will selectively kill only disease-causing, pathogenic bacteria.

14 Mar 2023

Gut microbiome may modulate the efficacy of CAR-T cell cancer immunotherapy

Scientists from German Cancer Research Center (DKFZ), together with colleagues from Germany, Israel, and the USA, have found that the gut microbiome may modulate the efficacy of CAR-T cellular immunotherapy CAR-T cells in patients with B cell lymphomas.

14 Mar 2023

Cancer News and Research

Study discovers the ability of certain blood immune cells to proliferate

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

Immune landscape in invasive ER+ breast cancers reveals a macrophage-driven microenvironment

New combination therapy regimen may reduce prostate cancer progression or death by 37%

Cancer cells use new DNA repair mechanism to recover from next-generation cancer radiation therapy

Delaying paralysis in ALS by using designer DNA drug

Neoadjuvant dual immunotherapy and chemotherapy improve outcomes in patients with resectable NSCLC

Using a programmable control switch to deliver therapeutic RNA molecules to target cells

Potential approach to improve solid tumor T cell therapy

The impact of genome doubling on the development of cancer

Highlighting a potential sex‐specific precision immunotherapy strategy

Using PET and electron microscopy to generate 3D maps of mitochondrial networks in lung tumors

High doses of sucralose limit T cell proliferation and differentiation

First molecular images of olfaction sets the stage to create novel smells

Study examines the role of dietary vitamin A in preventing or treating AAP

Age-related sarcopenia prevented by AAV1.NT-3 gene therapy

Aston University receives funding for the development of a diagnostic tool for children with brain tumors

High correlation between the product of a gene in the majority of cancers

Rice biologists embark on a three-year project to create genetically encoded antibiotics

Gut microbiome may modulate the efficacy of CAR-T cell cancer immunotherapy

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