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Plectasin's Velcro-Like Binding Holds Promise for Fighting Antimicrobial Resistance

A small antibiotic called plectasin uses an innovative mechanism to kill bacteria. By assembling into large structures, plectasin latches onto its target on the bacterial cell surface comparable to how both sides of Velcro form a bond.

24 May 2024

Researchers Develop Strategy to Replace Diseased Blood System Affected by Leukemia

Researchers have developed an approach to "deleting" a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells.

24 May 2024

How Immune Cells Decode Cancer's Turbocharged State

When cells become tumor cells, their metabolism changes fundamentally. Researchers at the University of Basel and the University Hospital Basel have now demonstrated that this change leaves traces that could provide targets for cancer immunotherapies.

22 May 2024

PhoreMost Introduces GlueSEEKER Platform for Discovery of Molecular Glue Degraders

PhoreMost Ltd., a leading UK biopharmaceutical company unlocking the next generation of drug targets, today announced the introduction of GlueSEEKER™. The new phenotypic screening platform expands the Company’s capabilities in this emerging therapeutic modality to support the systematic discovery and development of novel molecular glue degraders (MGDs) for targeted protein degradation (TPD).

From PhoreMost 22 May 2024

Sonification Reveals Hidden Patterns in Protein Folding Dynamics

By converting their data into sounds, scientists discovered how hydrogen bonds contribute to the lightning-fast gyrations that transform a string of amino acids into a functional, folded protein.

21 May 2024

Molecular Machinery Behind Plant Growth and Oil Production Deciphered

Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things -; and potentially how to change its effects.

20 May 2024

Study Reveals How tRNA Modification Influences Malaria Drug Resistance

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Massachusetts Institute of Technology (MIT), Columbia University Irving Medical Center (CUIMC), and Nanyang Technological University, Singapore (NTU Singapore), have discovered a link between malaria parasites’ ability to develop resistance to antimalarial drugs – specifically artemisinin (ART) – through a cellular process called transfer Ribonucleic acid (tRNA) modification.

20 May 2024

Discovery of Novel Adrenal Cell Type Linked to Monogamy in Oldfield Mice

What makes the oldfield mouse steadfastly monogamous throughout its life while its closest rodent relatives are promiscuous? The answer may be a previously unknown hormone-generating cell, according to a new study published online today in Nature from scientists at Columbia's Zuckerman Institute.

16 May 2024

Machine Learning Program Offers Insights Into Promoter Sequences and Transcription

A team led by researchers at UT Southwestern Medical Center developed deep learning models to identify a simple set of rules that govern the activity of promoters – regions of DNA that initiate the process by which genes produce proteins.

15 May 2024

Single-Molecule Study Reveals Unexpected Role of Protein Stiffness in Nuclear Transport

The degree of softness or rigidity in specific regions of proteins can affect how quickly or slowly those proteins enter the nucleus, according to research from the Francis Crick Institute and King's College London.

14 May 2024

Synthetic Anti-Clotting Agent Derived from Bloodsucking Organisms Saliva

Ticks, mosquitoes, and leeches are endowed by nature with a rapid method of preventing blood clotting while they feed on their host.

14 May 2024

Harnessing High-Performance Computing to Unravel the Emergence of Novel Viruses

Suddenly they appear and - like the SARS-CoV-2 coronavirus - can trigger major epidemics: Viruses that nobody had on their radar.

14 May 2024

LSTM Scientists Discover Treatment for Tissue Damage by African Spitting Cobra Venom

Scientists at Liverpool School of Tropical Medicine (LSTM) have discovered a groundbreaking new snakebite treatment to prevent the devastating tissue damage caused by African spitting cobra venom.

11 May 2024

Syntekabio to Unveil Novel Biologics Platform at 20th Annual PEGS Boston Summit

Syntekabio (226330.KQ), a global artificial intelligence (AI) drug discovery pioneer, today announced its participation at the 20th Annual PEGS Boston – The Essential Protein & Antibody Engineering Summit, where the company will highlight its novel biologics platform. The event is being held May 13-17, 2024 at the Omni Hotel at the Seaport, Boston, MA.

11 May 2024

Researchers Identify Natural Compounds for Parasitic Worm Treatment

An international team led by researchers at the University of Toronto has found a family of natural compounds with potential as new and more effective treatments for parasitic worms.

9 May 2024

New Insights Into PARP1 Biology Could Open Avenues to Improve Cancer Treatments

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.

8 May 2024

Targeting RNA Modifications: A Novel Approach for Neuroblastoma Treatment

Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain.

6 May 2024

Unveiling the Role of NCLX Protein in Mitochondrial Calcium Regulation and Autophagy

An article published in The Faseb Journal describes a Brazilian study analyzing the correlation between two key energy metabolism regulation processes: the absorption and release of calcium ions by mitochondria, the organelles that generate energy for cells; and autophagy induced by calorie restriction.

3 May 2024

New Method Sheds Light on How Protein Modifications Power T Cells

Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit.

30 Apr 2024

Mapping Small Molecule-Protein Interactions for Drug Development

For most human proteins, there are no small molecules known to bind them chemically (so called "ligands"). Ligands frequently represent important starting points for drug development but this knowledge gap critically hampers the development of novel medicines.

30 Apr 2024

Molecule News and Research

Plectasin's Velcro-Like Binding Holds Promise for Fighting Antimicrobial Resistance

Researchers Develop Strategy to Replace Diseased Blood System Affected by Leukemia

How Immune Cells Decode Cancer's Turbocharged State

PhoreMost Introduces GlueSEEKER Platform for Discovery of Molecular Glue Degraders

Sonification Reveals Hidden Patterns in Protein Folding Dynamics

Molecular Machinery Behind Plant Growth and Oil Production Deciphered

Study Reveals How tRNA Modification Influences Malaria Drug Resistance

Discovery of Novel Adrenal Cell Type Linked to Monogamy in Oldfield Mice

Machine Learning Program Offers Insights Into Promoter Sequences and Transcription

Single-Molecule Study Reveals Unexpected Role of Protein Stiffness in Nuclear Transport

Synthetic Anti-Clotting Agent Derived from Bloodsucking Organisms Saliva

Harnessing High-Performance Computing to Unravel the Emergence of Novel Viruses

LSTM Scientists Discover Treatment for Tissue Damage by African Spitting Cobra Venom

Syntekabio to Unveil Novel Biologics Platform at 20th Annual PEGS Boston Summit

Researchers Identify Natural Compounds for Parasitic Worm Treatment

New Insights Into PARP1 Biology Could Open Avenues to Improve Cancer Treatments

Targeting RNA Modifications: A Novel Approach for Neuroblastoma Treatment

Unveiling the Role of NCLX Protein in Mitochondrial Calcium Regulation and Autophagy

New Method Sheds Light on How Protein Modifications Power T Cells

Mapping Small Molecule-Protein Interactions for Drug Development

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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