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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

3 Apr 2023

Tighter Core of SARS-CoV-2 Spike Protein in New Variants Likely Improved the Virus's Ability to Infect Host Cells

Just as a tight core is a component of good physical fitness for humans, helping to stabilize our bodies, mutations that tightened the core of the SARS-CoV-2 spike protein in new variants may have increased the virus's fitness.

3 Apr 2023

First Steps Driving Antibiotic Resistance Discovered

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

3 Apr 2023

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

31 Mar 2023

Newly developed toolkit uses small molecules to control the activity of synthetic RNA

The Okinawa Institute of Science and Technology, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression.

31 Mar 2023

First atomic-level structure of 'oil-eating' enzyme paves way for bioengineered catalysts

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have produced the first atomic-level structure of an enzyme that selectively cuts carbon-hydrogen bonds-;the first and most challenging step in turning simple hydrocarbons into more useful chemicals.

31 Mar 2023

Gene variants that improve nitrogen utilization identified

Nitrogen as a fertilizer can boost yields. Too much nitrogen, on the other hand, can have negative consequences such as high energy consumption in fertilizer manufacturing.

31 Mar 2023

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Engineers at MIT and the University of Massachusetts Medical School have designed a new type of nanoparticle that can be administered to the lungs, where it can deliver messenger RNA encoding useful proteins.

31 Mar 2023

Clearance of senescent cells by boosting anti-viral immune response

Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

31 Mar 2023

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

A new study conducted at the National Eye Institute (NEI) has identified incredibly rare genetic variants that might uncover the mechanisms underlying the development of AMD.

31 Mar 2023

Harnessing a natural bacterial system to deliver proteins in mice and human cells

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals.

30 Mar 2023

Study helps understand at the cellular level how physical activity contributes to fitness during aging

Regular exercise can guarantee quality of life and longevity, specialists agree. However, exactly how exercise influences the functioning of muscle cells is poorly understood.

30 Mar 2023

SARS-CoV-2 infection hijacks and damages parts of infected cells' vital RNA machinery

Coronavirus disease (COVID-19) hijacks parts of infected cells' vital RNA machinery, thereby blocking important functions in the cells. These damaging changes in the RNA can likely be reversed, potentially leading to new drugs against COVID-19, University of Gothenburg researchers show.

30 Mar 2023

Study reports a new target to fight against antibiotic-resistant pneumonia

Increases in multidrug-resistance in the bacteria Streptococcus pneumoniae have made it the fourth-leading cause of death associated with antibiotic resistance.

30 Mar 2023

Study expands understanding of PAK1-related IDDMSSD

A recent study from Texas Children's Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay (IDDMSSD) with the identification of the first recurrently affected residue identified in the protein kinase domain of PAK1 protein.

30 Mar 2023

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Nanoparticles can be used to deliver messenger RNA encoding proteins to the lungs, results of a new study carried out at MIT and the University of Massachusetts Medical School show.

From Massachusetts Institute of Technology (MIT) 30 Mar 2023

Two subtypes of cells that produce insulin discovered

A team of scientists from the Van Andel Institute and the Max Planck Institute for Immunobiology and Epigenetics uncovered two unique subtypes of insulin-producing beta cells, or ß cells, each having important traits that could potentially be used to better understand and treat Type 1 and Type 2 diabetes.

30 Mar 2023

Artificial cells to serve as the powerhouse of the future

Chloroplasts and mitochondria are responsible for producing energy in nature, which is essential for creating sustainable, artificial cells in the lab. In addition to being “the powerhouses of the cell,” as the adage from middle school biology goes, mitochondria are also one of the most difficult intracellular components to artificially clone.

30 Mar 2023

Cocklebur fruit shows potential to protect the skin and help enhance collagen production

The fruit of the cocklebur plant, which grows worldwide and is often considered a noxious weed, has antioxidant and anti-inflammatory components that could make it useful as a skin protectant, according to new research.

29 Mar 2023

Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer That...

Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.

29 Mar 2023

Protein News and Research

Further Reading

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Tighter Core of SARS-CoV-2 Spike Protein in New Variants Likely Improved the Virus's Ability to Infect Host Cells

First Steps Driving Antibiotic Resistance Discovered

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Newly developed toolkit uses small molecules to control the activity of synthetic RNA

First atomic-level structure of 'oil-eating' enzyme paves way for bioengineered catalysts

Gene variants that improve nitrogen utilization identified

New nanoparticles can deliver mRNA encoding CRISPR/Cas9 components to the lungs

Clearance of senescent cells by boosting anti-viral immune response

Rare genetic variants identified that point to MAC as a therapeutic target for age-related macular degeneration

Harnessing a natural bacterial system to deliver proteins in mice and human cells

Study helps understand at the cellular level how physical activity contributes to fitness during aging

SARS-CoV-2 infection hijacks and damages parts of infected cells' vital RNA machinery

Study reports a new target to fight against antibiotic-resistant pneumonia

Study expands understanding of PAK1-related IDDMSSD

New nanoparticles can perform gene editing in the lungs, paving the way for inhalable therapies

Two subtypes of cells that produce insulin discovered

Artificial cells to serve as the powerhouse of the future

Cocklebur fruit shows potential to protect the skin and help enhance collagen production

Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer That...

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