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Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

18 Feb 2021

Research links blood-clotting protein with CNS B-cell lymphoma growth

In people with central nervous system (CNS) lymphoma, cancerous B cells--a type of white blood cell--accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels.

18 Feb 2021

Testing for inherited genes can help understand future cancer risk in pediatric patients

Because cancers in children are rare, many details about their biology remain unknown. In the field of cancer genetics, there's a limited understanding of how inherited genetic changes may contribute to the formation and growth of tumors.

17 Feb 2021

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Cancer cells and immune cells share something in common: They both love sugar. Sugar is an important nutrient. All cells use sugar as a vital source of energy and building blocks. For immune cells, gobbling up sugar is a good thing, since it means getting enough nutrients to grow and divide for stronger immune responses. But cancer cells use sugar for more nefarious ends.

17 Feb 2021

Combining cholesterol-lowering medications and lifestyle interventions may yield better benefits

Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife.

17 Feb 2021

New understanding of tumor microenvironment could help enhance immunotherapy

A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.

From University of Pittsburgh 16 Feb 2021

Machine learning approach to identify drugs that could be repurposed to fight Covid-19

When the Covid-19 pandemic struck in early 2020, doctors and researchers rushed to find effective treatments.

16 Feb 2021

Antioxidant in green tea may lead to new anti-cancer drugs

Green tea contains an antioxidant that may boost the concentrations of p53, called the “guardian of the genome,” for its potential to kill cancerous cells.

15 Feb 2021

Gene-based blood test may predict treatment success in people with metastatic melanoma

A test that monitors blood levels of DNA fragments released by dying tumor cells may serve as an accurate early indicator of treatment success in people in late stages of one of the most aggressive forms of skin cancer, a new study finds.

From New York University (NYU) 15 Feb 2021

Study reveals the structure of heat shock proteins that could treat Huntington's disease

In Huntington's disease, a faulty protein aggregates in brain cells and eventually kills them. Such protein aggregates could, in principle, be prevented with a heat shock protein.

15 Feb 2021

Researchers identify protein sequences that might be used by SARS-CoV-2 to infect cells

Researchers at EMBL Heidelberg have identified sequences in human proteins that might be used by SARS-CoV-2 to infect cells. They have discovered that the virus might hijack certain cellular processes, and they discuss potentially relevant drugs for treating COVID-19.

12 Feb 2021

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

With two commercially available inhibitors, the cell cycle of the cancer cells in the childhood tumor neuroblastoma can be disrupted at a key point causing tumor cell death.

12 Feb 2021

Scientists identify mystery protein that explains the origins of Parkinson's Disease

Researchers have made a “vital step” toward inferring the origins of Parkinson’s disease—a neurological condition that is rapidly growing in the world.

11 Feb 2021

An outlook on latest trends in peptide drug discovery and development

Currently, there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.

11 Feb 2021

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond.

11 Feb 2021

Scientists use new approach to avert drug resistance in glioblastomas

In far too many cases over the years, scientists have discovered promising new cancer treatments, only to report later that the tumor cells found ways to become resistant. These disappointing results have made overcoming drug resistance a major goal in cancer research.

11 Feb 2021

New simplified approach for producing pharmaceutical substances

Tetrahydroisoquinolines (THIQ) are organic compounds, whose structure includes a benzene ring merged with a nitrogen-containing cycle.

11 Feb 2021

New therapeutic approach to restore the effectiveness of immune cells

Prompted by the need to improve conventional treatments for people infected with the human immunodeficiency virus (HIV-1), a team from the Institut national de la recherche scientifique (INRS) has identified a therapeutic approach to restore the effectiveness of immune cells.

10 Feb 2021

New protein quality control system could enhance full-length translation in bacteria

Professor Sang Woo’s research group has designed a synthetic protein quality control system to improve the full-length translation in bacteria.

9 Feb 2021

New platform may accelerate genomic medicine research, drug therapies

A research team, headed by Cleveland Clinic, has designed a novel personalized genomic medicine platform that would help speed up genomic medicine studies as well as genome-informed drug discovery. The results of the new study have been recently published in the Genome Biology journal.

9 Feb 2021

Drugs News and Research

Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

Research links blood-clotting protein with CNS B-cell lymphoma growth

Testing for inherited genes can help understand future cancer risk in pediatric patients

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Combining cholesterol-lowering medications and lifestyle interventions may yield better benefits

New understanding of tumor microenvironment could help enhance immunotherapy

Machine learning approach to identify drugs that could be repurposed to fight Covid-19

Antioxidant in green tea may lead to new anti-cancer drugs

Gene-based blood test may predict treatment success in people with metastatic melanoma

Study reveals the structure of heat shock proteins that could treat Huntington's disease

Researchers identify protein sequences that might be used by SARS-CoV-2 to infect cells

Cell cycle of cancer cells can be disrupted using two commercially available inhibitors

Scientists identify mystery protein that explains the origins of Parkinson's Disease

An outlook on latest trends in peptide drug discovery and development

Inherited genetic variation plays a role in how patients respond to cancer immunotherapy

Scientists use new approach to avert drug resistance in glioblastomas

New simplified approach for producing pharmaceutical substances

New therapeutic approach to restore the effectiveness of immune cells

New protein quality control system could enhance full-length translation in bacteria

New platform may accelerate genomic medicine research, drug therapies

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