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Researchers identify key molecular processes used by coronaviruses to survive

When a coronavirus--including SARS-CoV-2, which causes COVID-19--infects someone, it hijacks the person's cells, co-opting their molecular machinery for its own survival and spread.

9 Dec 2020

Gene therapy and medication can provide certain beneficial effects of physical exercise

Jose Bianco Moreira from NTNU is now convinced that gene therapy can be used to achieve the positive health benefits of physical exercise.

7 Dec 2020

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial, Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting.

7 Dec 2020

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

A subcutaneous injection of the immune-boosting drug teclistamab was found to be safe and elicit responses in a majority of patients with relapsed or refractory multiple myeloma, according to findings from a multi-institutional phase I study being presented by Alfred L. Garfall, MD, an assistant professor of Medicine in the division of Hematology-Oncology in the Perelman School of Medicine at the University of Pennsylvania, at the annual American Society of Hematology & Exposition Meeting on Dec. 5 (abstract #180).

7 Dec 2020

Researchers determine 3D structures of RNA hybridization with artificial nucleic acids

As medical research progresses, traditional treatment protocols are being rapidly exhausted. New approaches to treat diseases that do not respond to conventional drugs are the need of the hour.

4 Dec 2020

Drug meant for bacterial infections can combat weight gain

A drug originally developed to treat bacterial infections has proved capable of boosting the metabolism and attenuating the weight gain induced by a fatty diet in tests with mice. The study was conducted at the University of Campinas (UNICAMP) with FAPESP's support, and the findings have just been published in the journal Science Advances.

3 Dec 2020

Specific immune mechanism in COVID-19 patients triggers inflammatory process

Researchers at the University of São Paulo (USP) in Brazil have demonstrated for the first time that in COVID-19 patients an immune mechanism known as the inflammasome participates in activation of the inflammatory process that can damage several organs and even lead to death.

3 Dec 2020

Researchers determine role of NLRP1 protein in detecting the common cold virus

The role of a protein in detecting the common cold virus and kickstarting an immune response to fight infection has been uncovered by a team of scientists from Nanyang Technological University, Singapore (NTU Singapore), the Agency for Science, Technology and Research (A*STAR) and the National University of Singapore.

From Nanyang Technological University Singapore (NTU Singapore) 3 Dec 2020

Environmental and exogenous compounds can interact with therapeutic drugs, shows study

According to scientific estimations, humans are exposed to at least 10,000 to 100,000 environmental and exogenous compounds in an individual lifetime, which are mainly absorbed through our dietary.

3 Dec 2020

Study identifies a promising target for cancer treatment

If there is a positive aspect in cancer’s random biology, it is that the same characteristics that promote the growth of cancer cells usually present opportunities for destroying them.

2 Dec 2020

Study shows metabolic state of disease-causing parasite influences its resistance to drugs

A new study has revealed how a disease-causing parasite is able to resist the present range of therapies. The study was recently published in eLife.

2 Dec 2020

Study: Painkillers interfere with auxin flow essential for developmental processes in plants

For centuries humans were using willow barks to treat a headache or an inflamed tooth. Later, the active ingredient, the plant hormone salicylic acid, was used to develop painkillers like Aspirin.

2 Dec 2020

UofL researcher finds less toxic way to deliver medicines

University of Louisville researchers have found a less toxic way to deliver medicines by using the natural lipids in plants, particularly grapefruit and ginger.

30 Nov 2020

Researchers explain the effectiveness of anti-diabetic drug

An international team of researchers has explained the action mechanism of incretin-based medications in diabetes treatment.

27 Nov 2020

Researchers identify potential new treatments for blindness

Vision loss associated with inherited genetic disease or aging is predicted to affect as many as 16 million people in the world.

27 Nov 2020

CAR T cells display signs of efficacy against hard-to-treat pediatric cancer in phase 1 trial

A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue.

26 Nov 2020

Warwick researchers design computational model to enable drug predictions against COVID-19

A computational model of a human lung cell has been used to understand how SARS-CoV-2 draws on human host cell metabolism to reproduce by researchers at the University of Warwick.

From The University of Warwick 26 Nov 2020

Cell survival protein could protect the kidneys from 'bystander' damage during cancer therapy

Australian researchers have identified a protein that could protect the kidneys from 'bystander' damage caused by cancer therapies.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 26 Nov 2020

Study shows how bacteria develop resistance to antibiotics

A group of researchers has successfully evolved the common microorganisms Escherichia coli at the experimental level.

25 Nov 2020

Study: Benefits of immunotherapy can be improved by boosting stem cell activity

Immune-system T cells have been reprogrammed into regenerative stem cell-like memory (TSCM) cells that are long-lived, highly active "super immune cells" with strong antitumor activity, according to new research from Georgetown Lombardi Comprehensive Cancer Center.

24 Nov 2020

Drugs News and Research

Researchers identify key molecular processes used by coronaviruses to survive

Gene therapy and medication can provide certain beneficial effects of physical exercise

CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Subcutaneous injection of teclistamab drug shows promise in treating aggressive multiple myeloma

Researchers determine 3D structures of RNA hybridization with artificial nucleic acids

Drug meant for bacterial infections can combat weight gain

Specific immune mechanism in COVID-19 patients triggers inflammatory process

Researchers determine role of NLRP1 protein in detecting the common cold virus

Environmental and exogenous compounds can interact with therapeutic drugs, shows study

Study identifies a promising target for cancer treatment

Study shows metabolic state of disease-causing parasite influences its resistance to drugs

Study: Painkillers interfere with auxin flow essential for developmental processes in plants

UofL researcher finds less toxic way to deliver medicines

Researchers explain the effectiveness of anti-diabetic drug

Researchers identify potential new treatments for blindness

CAR T cells display signs of efficacy against hard-to-treat pediatric cancer in phase 1 trial

Warwick researchers design computational model to enable drug predictions against COVID-19

Cell survival protein could protect the kidneys from 'bystander' damage during cancer therapy

Study shows how bacteria develop resistance to antibiotics

Study: Benefits of immunotherapy can be improved by boosting stem cell activity

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