Immune System News and Research

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UNC Researchers Unveil CAR-NKT Therapy for Enhanced Antitumor Activity

In the fight against cancer, chimeric antigen receptor T cell (CAR-T) therapy has achieved notable success in treating blood cancers. However, it has been largely ineffective against solid tumors.

8 Oct 2024

Scientists Successfully Map the Entire Fruit Fly Brain

A team of scientists supported by the National Institutes of Health (NIH)'s The BRAIN Initiative, including Davi Bock, Ph.D., Associate Professor of Neurological Sciences at UVM's Robert Larner, M.D. College of Medicine, recently made a substantial advancement in neurobiological research by successfully mapping the entire brain of Drosophila melanogaster, more commonly known as the fruit fly.

3 Oct 2024

Understanding the Impact of Natural Flu Infections on Vaccine Effectiveness

Researchers from the University of Georgia discovered in a recent study supported by the National Institutes of Health that the effectiveness of upcoming influenza vaccinations is significantly influenced by the body's innate immunity from prior flu episodes.

1 Oct 2024

Targeting the TCA Cycle to Reduce Post-TB Mortality

Researchers at Baylor College of Medicine and other institutions have discovered a mechanism that causes the long-term decline in immune response observed after tuberculosis (TB) is successfully treated.

1 Oct 2024

29 Novel Antibodies Targeting Drug-Resistant Klebsiella Pneumoniae Identified

Research at UMC Utrecht has identified 29 novel antibodies against the bacterium Klebsiella pneumoniae, an important cause of drug-resistant infections.

27 Sep 2024

New Method Detects Peroxymonocarbonate and Its Role in Cellular Responses

High levels of carbon dioxide (CO2) in the atmosphere can alter not only the climate of our planet but also the functioning of our cells.

24 Sep 2024

A New Understanding of the Effects of Fever on Immune Cells

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -; in a particular subset of T cells -; cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.

23 Sep 2024

The Role of Ancient Viral Sequences in Gene Regulation

For any organism to survive and thrive, its cells must tightly control which genes are activated when, and where.

19 Sep 2024

Research Shows a Causal Role of Histone Modifications in Gene Regulation

For any organism to survive and thrive, its cells must strictly control which genes are active when and where.

19 Sep 2024

Modified Nucleotides Boost saRNA Vaccine Efficacy and Protection Against SARS-CoV-2

Modified nucleotides like m5C in saRNA enhance vaccine efficacy, stability, and reduce inflammation, offering a promising approach for SARS-CoV-2 protection.

18 Sep 2024

Lipids Found to Play Key Role in Cancer Immune Evasion

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes.

18 Sep 2024

Innovative Approach Supercharges T Cells by Transferring Healthy Mitochondria

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion.

16 Sep 2024

CRISPR and Antibodies Offer New Hope for Improving CAR-T Cell Therapy Outcomes

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

13 Sep 2024

Developing Techniques for Imaging Biomolecules

Scientists are working to create quicker, more quantitative, and more publicly available methods of seeing biomolecules in living cells to speed up biotechnology discoveries, such as the production of lifesaving drugs.

11 Sep 2024

Decoding the Infant Microbiome's Three Pioneers

Researchers discovered that newborn newborns had one of three pioneer bacteria in their stomach immediately after birth, one of which might be exploited to generate novel personalized infant therapeutic probiotics.

9 Sep 2024

Atypical B Cells Play a Central Role in COVID-19 Vaccine Response

Vaccines function by strengthening defenses against viruses that invade human bodies. Vaccination against COVID-19 teaches the human immune system's specialized B cells how to identify the virus.

5 Sep 2024

Innovative Computational Tool Analyzes Gut Microbiome for Early Health Insights

A team of Mayo Clinic researchers has developed a unique computational tool that analyzes the gut microbiome, a complex ecosystem of trillions of bacteria, fungi, viruses, and other microorganisms within the digestive system, to provide insights about general well-being.

5 Sep 2024

Insights into Peptide Clumping Could Transform Drug Design and Material Science

Scientists from China have investigated how short peptide chains aggregate together in order to deepen our understanding of the process, which is crucial for drug stability and material development.

4 Sep 2024

Melbourne Researchers Achieve Breakthrough in Creating Human-Like Blood Stem Cells

Melbourne researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body.

3 Sep 2024

Microbiotica Secures Approvals to Begin Clinical Studies in EU and UK for New Microbiome Medicines

Microbiotica, a biopharma company developing a pipeline of oral precision microbiome medicines called live biotherapeutic products (LBPs), is pleased to announce that it has received regulatory approvals to initiate clinical studies for its first two programmes in advanced melanoma (MELODY-1) and ulcerative colitis (COMPOSER-1) in selected EU countries and the UK. Both studies are due to start shortly, with initial data readouts expected by the end of 2025.

30 Aug 2024