Infectious Diseases News and Research

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Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Insilico Medicine, a clinical-stage biotech company powered by generative AI, today announces that China National Medical Products Administration (NMPA) has approved the Investigational New Drug (IND) application for ISM3312, an orally available 3CLpro inhibitor generated and designed with the support of Insilico's proprietary generative chemistry platform Chemistry42 for the treatment of COVID-19.

24 Feb 2023

Earthquakes pose severe long-term impacts on the health of Syrian refugees

Among those in greatest peril after the devasting earthquakes in the Middle East are some 6.6 million internally displaced persons in Syria, as well as 1.9 million Syrian refugees living in Turkey, according to estimations from the United Nations High Commissioner for Refugees.

24 Feb 2023

Genetic study emphasizes the significance of “balancing selection” in evolution

Nature can maintain various genetic features in balance as a species grows over millions of years, much like a merchant of old would do when balancing the weights of two distinct products on a scale.

23 Feb 2023

Limiting antibiotic use in livestock associated with reduction in antibiotic-resistant infection

A California policy restricting antibiotic use in animals raised for food is associated with a reduction in one type of antibiotic-resistant infection in people in the state, according to a new study published today in the journal Environmental Health Perspectives.

23 Feb 2023

Mount Sinai researchers reveal mechanisms underlying autoimmunity in Down syndrome

Scientists at the Icahn School of Medicine at Mount Sinai in New York have identified which parts of the immune system go awry and contribute to autoimmune diseases in individuals with Down syndrome.

23 Feb 2023

Study shows how convalescent plasma can be used as effective treatment during future pandemics

Three years into the COVID-19 pandemic, new variant outbreaks continue to fuel economic disruptions and hospitalizations across the globe.

22 Feb 2023

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

This study is led by Dr. Anjian Xu (Beijing Clinical Research Institute, Beijing Friendship Hospital, Capital Medical University), Dr. Min Cong (Liver Research Center, Beijing Friendship Hospital, Capital Medical University) and Dr. Junying Ding (Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University).

20 Feb 2023

High diversity in T-cell receptor genes explains diverse response to infections

Researchers from Karolinska Institutet have demonstrated that the genes that encode the T cell receptors change significantly between individuals and communities, which could help explain why people react differently to certain diseases.

17 Feb 2023

AutoPLP helps detect mutating pathogenic variants quickly and accurately

As we now know from our experience with the COVID-19 pandemic, the microbes responsible for some infections can rapidly mutate into variants that evade detection and treatment.

16 Feb 2023

B lymphocytes stimulate the in-demand production of innate immune cells during infection

An SOS signals a call for immediate action during an emergency to request a need for protection. The immune system, a network of defense mechanisms, enhances protection to recover the body's internal stability.

16 Feb 2023

LJI receives funding from NIAID to lead the biggest human immunoprofiling effort

A new grant of over $17 million from the National Institute of Allergy and Infectious Diseases (NIAID) has established La Jolla Institute for Immunology (LJI) as the leading institute for human immunology data curation, analysis, and dissemination. With this funding, LJI has taken the helm of the Human Immunology Project Consortium Data Coordinating Center, a critical tool in the effort to fuel scientific collaboration in immunoprofiling and highlight findings from the overall Human Immunology Project Consortium (HIPC).

16 Feb 2023

Experts demonstrate clear differences in virulence among the major clades of mpox virus

Scientists from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have removed a major roadblock to better understanding of mpox (formerly, monkeypox).

15 Feb 2023

Study reveals how two proteins enable drug-resistant MRSA bacterium to secrete toxins

Antimicrobial resistance represents one of the top 10 global public health threats according to the World Health Organization, and scientists have been scrambling to find new tools to cure the most deadly drug-resistant infections.

14 Feb 2023

Extracts from two common wild plants block SARS-CoV-2 from entering human cells

Two common wild plants contain extracts that inhibit the ability of the virus that causes COVID-19 to infect living cells, an Emory University study finds.

13 Feb 2023

Novel compound curtails influenza virus replication

Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of influenza.

10 Feb 2023

Protein that facilitates cancer-causing viruses dodge the immune system

Numerous cancers have been related to the viruses Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV). For the first time, UNC School of Medicine researchers have shown that these viruses elude the innate immune response by using a human protein called barrier-to-autointegration factor 1, or BAF, which enables the viruses to propagate and cause disease.

7 Feb 2023

Gaining insights into human disease biology through CRISPR platforms

In this interview, we speak with Laralynne Przybyla about how she is utilizing CRISPR platforms to understand human disease biology in greater detail.

From Society for Laboratory Automation and Screening (SLAS) 7 Feb 2023

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

A genetic mutation in the SPTSSA gene is identified as the cause of Hereditary Spastic Paraplegia, a rare disease that causes progressive weakness, stiffness and spasticity in the lower extremities, according to a study, "SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia," published in Brain on on Jan. 30.

1 Feb 2023

Novel chemical tool reveals how bacteria adapt to the host environment

A research team guided by Professor Xiang David Li of The University of Hong Kong’s (HKU) Department of Chemistry created a new chemical tool to unveil how bacteria adjust to the host environment and control host cells.

1 Feb 2023

UNC research describes another layer to the challenge of HIV latency

When people living with HIV take antiviral therapy (ART), their viral loads are driven so low that a standard blood test cannot detect the virus.

1 Feb 2023

Infectious Diseases News and Research

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Earthquakes pose severe long-term impacts on the health of Syrian refugees

Genetic study emphasizes the significance of “balancing selection” in evolution

Limiting antibiotic use in livestock associated with reduction in antibiotic-resistant infection

Mount Sinai researchers reveal mechanisms underlying autoimmunity in Down syndrome

Study shows how convalescent plasma can be used as effective treatment during future pandemics

Revealing a novel form of ferroptosis that may be implicated in diseases caused by acute injury

High diversity in T-cell receptor genes explains diverse response to infections

AutoPLP helps detect mutating pathogenic variants quickly and accurately

B lymphocytes stimulate the in-demand production of innate immune cells during infection

LJI receives funding from NIAID to lead the biggest human immunoprofiling effort

Experts demonstrate clear differences in virulence among the major clades of mpox virus

Study reveals how two proteins enable drug-resistant MRSA bacterium to secrete toxins

Extracts from two common wild plants block SARS-CoV-2 from entering human cells

Novel compound curtails influenza virus replication

Protein that facilitates cancer-causing viruses dodge the immune system

Gaining insights into human disease biology through CRISPR platforms

Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

Novel chemical tool reveals how bacteria adapt to the host environment

UNC research describes another layer to the challenge of HIV latency

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