in vitro News and Research

RSS

The Function of Stem Cell Barriers in the Treatment of Fertility

A set of molecules controls cells as they proliferate and take on certain identities and spatial placements within a human embryo as it develops.

18 Jul 2023

Genetically Modified iPS Cell Applications for Fabry Disease

iPS cells have had a significant impact on biology and medicine, and they are expected to increase regenerative medicine. Clinical trials with various cell types derived from iPS cells have been performed since 2014 when a sheet of retinal pigment epithelial cells obtained from iPS cells was transplanted into patients with age-related macular degeneration.

4 Jul 2023

Study Links Timing of Childhood Adversity With Epigenetic Patterns in Adolescents

Childhood adversity-;circumstances that threaten to a child's physical or psychological well-being--has long been associated with poorer physical and mental health throughout life, such as greater risks of developing cardiac disease, cancer, or depression.

14 Jun 2023

Exploring the Regulatory Mechanism and Physiological Significance of P62 Phosphorylation

Nuclear factor erythroid 2-related factor 2 (NRF2) is a master transcription factor with a role in maintaining oxidative stress response. It can be triggered by both redox-dependent and redox-independent pathways.

13 Jun 2023

Researchers Discover Novel Combination Therapy to Counter Antibiotic-resistant Mycobacterium Abscessus Infections

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Nanyang Technological University Singapore (NTU Singapore) and National University Hospital (NUH), have discovered a novel therapy by combining two antibiotics, rifaximin and clarithromycin, to treat Mycobacterium abscessus (M. abscessus), a non-tuberculous mycobacterium (NTM) that causes chronic lung-related infections.

9 Jun 2023

Breakthrough: Sequencing Functional Antibody Proteins Directly from Human Blood

Rapid Novor Inc., the world’s leader in mass spectrometry (MS)-based antibody protein sequencing, announced today that its REpAb® antibody discovery platform was used to successfully sequence a complex mixture of functional antibodies directly from the serum of a human patient after receiving a COVID-19 vaccine.

6 Jun 2023

Chemical in Widely Used Sweetener is "Genotoxic", Study Finds

A new study finds a chemical formed when we digest a widely used sweetener is "genotoxic," meaning it breaks up DNA.

1 Jun 2023

Researchers Design Artificial Fibers that can Change Shape and Generate Force Like a Muscle

In two new studies, North Carolina State University researchers designed and tested a series of textile fibers that can change shape and generate force like a muscle.

26 May 2023

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Proteins are large, complex molecules that play many critical roles in the body and are produced following the instructions encoded in DNA.

18 May 2023

Discovery of Shanghai APP Mutation Offers New Avenues for Treatment of Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting tens of millions of people worldwide, and it is the most common cause of dementia.

15 May 2023

Study Reveals How the Formation of Microtubules Drives Cell Division

Cellular life hinges on a network of hollow cables called microtubules dynamically lengthening and shortening according to the needs of the moment.

2 May 2023

Computational Models can Help Determine the Identities and Roles of Individual Neurons

Investigators at Cedars-Sinai have created computer-generated models to bridge the gap between "test tube" data about neurons and the function of those cells in the living brain.

26 Apr 2023

Integrated-Gut-Liver-on-a-Chip can Improve Understanding of Non-Alcoholic Fatty Liver Disease

A new chip that holds different cell types in tiny, interconnected chambers could allow scientists to better understand the physiological and disease interactions between organs.

10 Apr 2023

Study Establishes Two Distinct Regulatory T Cell Populations

According to a recent study headed by the Children’s Hospital of Philadelphia (CHOP), a regulatory class of human T cells is descended from two distinct origins, one related to autoimmunity and one related to protective immunity.

10 Apr 2023

Novel Tridimensional Anticancer Agents Have the Ability to Overcome Drug Resistance in Cancer Cells

A research team co-led by chemists from City University of Hong Kong recently discovered novel, highly effective anticancer agents with tridimensional structures, which have high anticancer activity, low toxicity and the ability to overcome drug resistance in cancer cells.

7 Apr 2023

Generation of Monkey Blastoids Using Optimized Protocol

Human embryo development and early organ development remain unclear due to ethical concerns about using embryos for research and a scarcity of materials to investigate.

7 Apr 2023

MET+LEU Cocktail Prevents Cellular Senescence and Disrupted Proteostasis Induced by Myotube Atrophy

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 6, entitled, "Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail."

3 Apr 2023