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Study sheds light on the ability of melanomas to form early metastases

Research led by Queen Mary University of London has revealed novel insights into the mechanisms employed by melanoma cells to form tumours at secondary sites around the body.

21 Oct 2020

UNM researchers identify medications that could help fight COVID-19 infection

University of New Mexico researchers who combed through a "library" of previously approved drugs believe they have identified a medication with the potential to help speed a patient's recovery from SARS-CoV-2 infection.

19 Oct 2020

New nanoparticles can destroy drug-resistant cancer cells

Multidrug resistance, or MDR, is a process in which tumors become impervious to numerous drugs and is a major cause of failure in cancer chemotherapy.

19 Oct 2020

Researchers develop a new method for siRNA stabilization

In the gene controlling mechanism, known as RNA interference, the expression of particular genes is downregulated by siRNAs or endogenic microRNAs.

19 Oct 2020

New mechanism of metastatic cancer cells discovered in substrates of different stiffness

During metastasis, cancer cells actively interact with microenvironments of new tissues. How metastatic cancer cells respond to new environments in the secondary tissues is a crucial question in cancer research but still remains elusive.

19 Oct 2020

Key blood marker could offer the most effective treatment for melanoma

An Edith Cowan University (ECU) study has revealed that a key blood marker of cancer could be used to select the most effective treatment for melanoma.

19 Oct 2020

New laboratory test can capture and analyze the deadliest cells in brain cancer

Researchers have designed a laboratory test that can precisely examine the deadliest cells found in the most common and aggressive type of brain cancer.

19 Oct 2020

Study shows cocaine use in mice leads to formation of synapses

Drugs of abuse, like cocaine, are so addictive due in part to their cellular interaction, creating strong cellular memories in the brain that promote compulsive behaviors.

16 Oct 2020

Researchers identify potential drugs that could be repurposed as pan-coronavirus treatments

A large international consortium of almost 200 researchers from 14 leading institutions in six countries has studied three different coronaviruses - SARS-CoV-1, SARS-CoV-2, and MERS-CoV - with the aim of finding vulnerabilities shared by these three pathogens.

16 Oct 2020

Researchers identify drug that could overcome tumor resistance

Scientists have discovered that a drug that may make some melanoma tumors perceptible to the immune system, enabling them to be better targeted.

15 Oct 2020

Virus-mimicking drugs may overcome immunotherapy resistance in tumors

Researchers at the UCLA Jonsson Comprehensive Cancer Center have found that a drug that activates the body's natural defenses by behaving like a virus may also make certain stealthy melanoma tumors visible to the immune system, allowing them to be better targeted by immunotherapy.

15 Oct 2020

Study offers renewed hope for children suffering from myofibrillar myopathies

Stephen Greenspan and Laura Zah were devastated when they learned their son Alexander had a rare genetic mutation, which causes a deadly neuromuscular disease with no known treatment or cure.

15 Oct 2020

Innovative machine learning concepts can help develop new drugs

Tandem mass spectrometry is a powerful analytical tool used to characterize complex mixtures in drug discovery and other fields.

15 Oct 2020

Statins can reduce risk of heart attacks and other cardiovascular diseases

According to a study recently published in the eLife journal, cholesterol-lowering drugs, known as statins, may lower cancer risk in humans via a pathway unassociated with cholesterol.

15 Oct 2020

A combinational approach to fight against cancer

In their quest to destroy cancer cells, researchers are turning to combinational therapies more and more. Scientists from Germany and China have now combined a chemotherapeutic and photodynamic approach.

14 Oct 2020

Researchers discover a new mechanism to regulate nerve impulses

Researchers at Linköping University, Sweden, have discovered a new mechanism by which substances can open a certain type of ion channel and in this way regulate nerve impulses.

13 Oct 2020

Scientists develop new antimicrobial molecules from toxic proteins in wasp venom

A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has engineered powerful new antimicrobial molecules from toxic proteins found in wasp venom.

13 Oct 2020

Enzyme SSH1 impairs disposal of damaged tau and mitochondria leaking toxins

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

13 Oct 2020

Components leaking from broken muscle fibers activate 'satellite' muscle stem cells

While building a muscle damage model in a cultured system, a research collaboration between Kumamoto University and Nagasaki University in Japan has found that components leaking from broken muscle fibers activate "satellite" muscle stem cells.

13 Oct 2020

Severe cases of COVID-19 resemble systemic lupus erythematosus

Scientists from Emory Health Sciences have been observing an intense stimulation of immune cells in severe cases of COVID-19 disease. This activation of immune cells is similar to acute flares of systemic lupus erythematosus (SLE)—an autoimmune disease.

13 Oct 2020