Chromosome News and Research

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In the nucleus of each cell, the DNA molecule is packaged into thread-like structures called chromosomes. Each chromosome is made up of DNA tightly coiled many times around proteins called histones that support its structure.

Chromosomes are not visible in the cell’s nucleus—not even under a microscope—when the cell is not dividing. However, the DNA that makes up chromosomes becomes more tightly packed during cell division and is then visible under a microscope. Most of what researchers know about chromosomes was learned by observing chromosomes during cell division.

Each chromosome has a constriction point called the centromere, which divides the chromosome into two sections, or “arms.” The short arm of the chromosome is labeled the “p arm.” The long arm of the chromosome is labeled the “q arm.” The location of the centromere on each chromosome gives the chromosome its characteristic shape, and can be used to help describe the location of specific genes.

Persistent tumor mutation load may help predict outcome of novel immunotherapies

Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy.

27 Jan 2023

Effective anticancer strategy for selective killing of cancer cells

A study team headed by Dr Yuanliang Zhai from The University of Hong Kong’s (HKU) School of Biological Sciences and his associates from The Hong Kong University of Science and Technology (HKUST) and Institut Curie in France discovered a new mechanism of the human MCM2-7 complex in controlling replication initiation, which can be employed as a unique and effective anticancer method with the potential for selective death of cancer cells.

11 Jan 2023

Chilling tolerance trait in rice with the codon repeats at a single site

A recent study performed by Professor Chong Kang’s group from the Institute of Botany of the Chinese Academy of Sciences (CAS) has disclosed a fact that a novel cold domesticated repair mechanism for DNA damage in rice.

11 Jan 2023

First-ever chromosome-level genome sequences completed for sharks

The first chromosome level genome sequences for great hammerhead and shortfin mako sharks have shown that both species have experienced major population declines over a 250,000-year history.

5 Jan 2023

Analysis of genetic factors contributing to cleft lip and palate

Cleft lip and palate, which are mainly caused by genetic reasons, are two of the most common congenital malformations. It is still unknown which genes are exactly affected.

19 Dec 2022

Revealing the mechanism that ensures genome stability in normal cells

To create new cells, the old cells must divide. This is a constant, frequent, and pervasive process that begins with conception and culminates with death.

30 Nov 2022

Newly developed tool helps snip out faulty genes in a safe manner

Scientists from the Massachusetts Institute of Technology (MIT) have come up with a new tool that has the potential to detach faulty genes and exchange them with new ones in a highly safe and effective way.

From Massachusetts Institute of Technology (MIT) 25 Nov 2022

RNA-targeting strategy to repair the genetic cause of ALS and dementia

Researchers at UF Scripps Biomedical Research have created a potential treatment for a major factor in the development of ALS and dementia that functions by removing disease-causing RNA segments.

24 Nov 2022

The genetic mechanisms that induce protein decline in modern maize

The wild ancestor of maize, teosinte, contains three times as much seed protein as the majority of cultivars of maize today. The mechanisms causing the declining seed protein content in maize hybrids and inbred lines were identified by researchers at the Chinese Academy of Sciences Headquarters.

17 Nov 2022

New study figures out which patients will react to immunotherapy

According to a new study, patients with head and neck cancer who have more chromosome 9 genetic material in their cancer cells survive three times longer after accepting immunotherapy than patients who have less of it.

From New York University (NYU) 15 Nov 2022

HIV’s covert methods of evading treatment and immunity

According to Duke Health researchers, the human immunodeficiency virus (HIV) appears to be driven into a latent state, lurking in cells only to erupt once more. This immune response likely evolved to help fight infections.

15 Nov 2022

Newly sequenced Honeycrisp apple genome could be a boon for scientists and breeders

A team of researchers has sequenced the Honeycrisp apple genome, a boon for scientists and breeders working with this popular and economically important cultivar.

27 Oct 2022

New explanation for how chromosome recombination is regulated during sexual reproduction

Scientists from the Max Planck Institute for Plant Breeding Research and the Max Planck Institute for Dynamics and Self-Organization (MPI-DS) suggest an explanation for the century-old mystery of how chromosome recombination is regulated during sexual reproduction.

From The Max Planck Institute 25 Oct 2022

High-quality chromosome-level reference genome for A. gigantea

According to the International Union for Conservation of Nature’s Red List, Aldabra giant tortoises are in danger of extinction, which means the species stands a high risk of extinction in the wild.

14 Oct 2022

Genetic speciation method to make new hybrid species

The evolution of a new species by hybridization from two already described species without a change in chromosome number is very rare in the animal kingdom.

12 Oct 2022

Insights into the evolution of banana domestication

People on the island of New Guinea are said to have domesticated bananas 7,000 years ago. However, the history of banana domestication is convoluted, and their categorization is widely discussed, as the boundaries between species and subspecies are frequently ambiguous.

10 Oct 2022

Genome of domesticated banana varieties contains traces of three unknown ancestors

Bananas are thought to have been first domesticated by people 7,000 years ago on the island of New Guinea.

10 Oct 2022

Research team outlines three-step technique that lets human body defend against Hep B

A team from the University of Geneva (UNIGE) has unraveled the precise operation of this defensive mechanism after finding a crucial protein complex that is active when our body is infected by the virus, paving the path for novel treatment targets.

5 Oct 2022

Genome of the earliest common ancestor of all mammals identified

From a platypus to a blue whale, all living mammals today are derived from a single ancestor that existed around 180 million years ago. Although nothing much is known about this species, an international team of experts has now computationally rebuilt how its DNA is organized.

From The University of California, Davis 28 Sep 2022