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Ribonucleic acid (RNA) is a biologically important type of molecule that consists of a long chain of nucleotide units. Each nucleotide consists of a nitrogenous base, a ribose sugar, and a phosphate.

Genetic Influences on Lifespan Variance and Healthspan in Caenorhabditis elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

25 Jun 2024

Integrated Cellular Map of Heart Fibrosis Unlocks New Treatment Avenues

Scientists at the Victor Chang Cardiac Research Institute in Australia have produced a first of its kind integrated map of heart cells which unlocks the process of cardiac fibrosis – a major cause of heart failure.

24 Jun 2024

New Gene-Editing Tool Offers More Precision and Flexibility

Researchers at the University of Sydney have created a gene-editing instrument that is more precise and adaptable than the industry standard CRISPR, which has transformed genetic engineering in biotechnology, agriculture, and medicine.

24 Jun 2024

Study Identifies Three Distinct Subtypes of Clear Cell Renal Cell Carcinoma Using Radiomics and Transcriptomics

Using transcriptomics and radiomics data clustering and its association with molecular characteristics, clinical pathologies, and prognosis to define intrinsic subtypes of ccRCC.

24 Jun 2024

Detecting Auto-Antibodies for Early Identification of High-Risk COVID-19 Cases

Researchers recently discovered that auto-antibodies against their type 1 interferons, crucial immunological signaling proteins, were present in some COVID-19 patients.

20 Jun 2024

Scientists Discover Impact of Mycoviral Infection on Fungicide Sensitivity in Oomycete Pathogens

As detrimental as viruses may sound, they can be helping hands for farmers when it comes to dealing with plant pathogens.

20 Jun 2024

Ancestry Bias can Cause CRISPR Screens to Miss Cancer Dependencies

CRISPR/Cas9 gene editing has made possible a multitude of biomedical experiments including studies that systematically turn off genes in cancer cells to look for ones that the cancer cells heavily depend on to survive and grow.

17 Jun 2024

Johns Hopkins Scientists Engineer Synthetic Cells to Mimic Symmetry Breaking

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists at Johns Hopkins Medicine say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called "symmetry breaking."

14 Jun 2024

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Whether forcing adult cardiomyocytes to reverse from the oxidative phosphorylation phenotype to the glycolysis phenotype would also restore their mitotic ability.

13 Jun 2024

Simplified Proteomics Method Could Open the Door Toward Precision Medicine

Proteins are workhorses that carry out most of the biological functions in our cells.

12 Jun 2024

Innovative ssREAD Database Provides Rich Alzheimer's Disease RNA-Seq Resources for Researchers

The Single-cell and Spatial RNA-seq databasE for Alzheimer’s Disease, or ssREAD.

12 Jun 2024

CSHL Researchers Reveal New Protein Networks in RNA Splicing Regulation

Bodybuilders and cellular mechanisms agree generating protein is a heavy lift. To complete the task, cells rely on complexes called spliceosomes.

11 Jun 2024

Innovative Gene Editing Elevates Photosynthetic Efficiency in Food Crops

A team from the Innovative Genomics Institute at the University of California, Berkeley (UCB) has produced an increase in gene expression in a food crop by changing its upstream regulatory DNA.

10 Jun 2024

New research identifies and mitigates bias in CRISPR-Cas9 gene editing

A phenomics approach to study proximity bias and the unrelated chromosomal truncations.

10 Jun 2024

Multiciliated Cell Differentiation Regulated by an Alternative Cell Cycle

A fertilized egg can develop into a baby through the amazing process of cell division, while a malignant cell can become a malignant tumor. Since there is so much on the line, nature maintains strict control over it through a mechanism known as the cell cycle that scientists once believed they thoroughly understood.

7 Jun 2024

Columbia Studies Uncover Misidentification of Gut Stem Cells

Two independent studies by Columbia scientists suggest that research into the gut's stem cells over the past 15 years has been marred by a case of mistaken identity: Scientists have been studying the wrong cell.

7 Jun 2024

Determining Sex in Ants

Researchers at the universities of Mainz and Lausanne have identified a noncoding gene as the deciding factor in determining sex in Argentine ants.

From University of Mainz 7 Jun 2024

Critical NPC Protein Nup358 Linked to Myeloid Disorders

Nuclear pore complexes (NPCs) are channels composed of multiple proteins that ferry molecules in and out of the nucleus, regulating many critical cellular functions, such as gene expression, chromatin organization and RNA processes that influence cell survival, proliferation, and differentiation.

6 Jun 2024

CRISPR/Cas Biosensors Address Sensitivity and Specificity Challenges in Detection

The mechanisms of CRISPR-Cas-based biosensors.

5 Jun 2024

New Microscopy Reveals Secrets of SARS-CoV-2 Replication

Recent research published in Nature Communications by a Stanford University team may provide more accuracy in drug development by examining at the nanoscale how the SARS-CoV-2 virus replicates in cells.

4 Jun 2024