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Novel method enables quick identification of small active substance molecules

Secondary natural substances that occur in numerous plants, bacteria and fungi can be anti-inflammatory, can ward off pathogens or even prevent the growth of cancer cells. However, making use of the riches provided by nature's medicine cabinet and identifying new natural substances is time-consuming, costly and labour-intensive. A team of bioinformaticians at Friedrich Schiller University Jena has now developed a method that enables much faster and easier identification of small active substance molecules.

18 Oct 2021

AI-powered tool rapidly identifies genetic causes of rare disorders with high accuracy

An artificial intelligence (AI)-based technology rapidly diagnoses rare disorders in critically ill children with high accuracy, according to a report by scientists from University of Utah Health and Fabric Genomics, collaborators on a study led by Rady Children's Hospital in San Diego. The benchmark finding, published in Genomic Medicine, foreshadows the next phase of medicine, where technology helps clinicians quickly determine the root cause of disease so they can give patients the right treatment sooner.

From The University of Utah 18 Oct 2021

Researchers develop chimeric exosomes that co-activate immune response and tumor microenvironment

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed macrophage–tumor chimeric exosomes that co-activate the immune response and tumor microenvironment to support cancer immunotherapy.

18 Oct 2021

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

At the beginning of neurodegenerative disease, the immune cells of the brain – the "microglia" – take up glucose, a sugar molecule, to a much greater extent than hitherto assumed.

18 Oct 2021

Pioneering gene therapy has long-lasting effects on children with deadly immune disorder

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.

18 Oct 2021

Mutant clones outcompete and eliminate early tumors, mouse study shows

Cells carrying mutations can out compete early tumors in the mouse esophagus, so they never make it into cancers, new research has shown.

15 Oct 2021

Type A immunoglobulins play a key role in keeping the intestinal flora in balance

The bacteria living in the intestine consist of some 500 to 1000 different species. They make up what is known as the intestinal flora, which plays a key role in digestion and prevents infections.

15 Oct 2021

Scientists show how skin T cells can damage other organs in stem cell transplant patients

More than 40,000 allogeneic hematopoietic stem cell transplants are carried out worldwide every year, mostly for patients suffering from leukemia or other diseases of the hematopoietic system.

15 Oct 2021

Study identifies DNA mutations that impact metabolism and insulin sensitivity in liver disease patients

For the first time, DNA mutations in liver cells have been identified that impact metabolism and insulin sensitivity in patients with liver disease.

15 Oct 2021

Study reveals gene responsible for food-dependent form of Cushing's Syndrome

A team of scientists in Montreal and Paris has succeeded in identifying the gene responsible for the development of a food-dependent form of Cushing's Syndrome, a rare disease affecting both adrenal glands.

15 Oct 2021

New research center brings advancements in genomic medicine to admixed individuals

One way to make health care more personalized is to use a person's DNA sequence -; or genome -; to predict their risk of disease. But as the field of precision medicine grows, so have concerns that we may be leaving a large fraction of Americans out.

From UC San Diego 13 Oct 2021

Study: Sex matters when it comes to susceptibility to infections and other health conditions

A University of Alberta-led study shows that when it comes to susceptibility to infections and other health conditions, sex matters.

13 Oct 2021

Study finds higher levels of air pollutants in regions near oil and gas wells

In a 14-year analysis of air quality across California, Stanford researchers observed higher levels of air pollutants within 2.5 miles of oil and gas wells, likely worsening negative health outcomes for nearby residents.

13 Oct 2021

Eating mushrooms may benefit a person's mental health, study reveals

Mushrooms have been making headlines due to their many health advantages. Not only do they lower one's risk of cancer and premature death, but new research led by Penn State College of Medicine also reveals that these superfoods may benefit a person's mental health.

From Penn State University 13 Oct 2021

Regulatory network impacting brain evolution found in “junk DNA,” says study

Human DNA has a close resemblance to that of the chimpanzee, which in evolutionary terms is the closest living relative of humans.

13 Oct 2021

Study details metabolic processes employed by SARS-CoV-2 to attack lung tissue

Scientists from the Karolinska Institutet discovered certain metabolic mechanisms that SARS-CoV-2 employs to attack lung tissue.

13 Oct 2021

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging.

12 Oct 2021

New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.

12 Oct 2021

Researchers unravel impacts of protein BRD4 on how DNA folds

Recent research enhances the understanding of certain cancers and complex congenital disorders.

8 Oct 2021

$Mesenchymal stem cells with enhanced fracture healing abilities identified$

Mesenchymal stem cells with enhanced fracture healing abilities identified

Mesenchymal stem cells (MSCs) are anticipated to harbor great potential in the area of regenerative medicine, which aims at restoring damaged tissues.

8 Oct 2021

Medicine News and Research

Novel method enables quick identification of small active substance molecules

AI-powered tool rapidly identifies genetic causes of rare disorders with high accuracy

Researchers develop chimeric exosomes that co-activate immune response and tumor microenvironment

Brain immune cells take up large amounts of sugar at the beginning of neurodegenerative disease

Pioneering gene therapy has long-lasting effects on children with deadly immune disorder

Mutant clones outcompete and eliminate early tumors, mouse study shows

Type A immunoglobulins play a key role in keeping the intestinal flora in balance

Scientists show how skin T cells can damage other organs in stem cell transplant patients

Study identifies DNA mutations that impact metabolism and insulin sensitivity in liver disease patients

Study reveals gene responsible for food-dependent form of Cushing's Syndrome

New research center brings advancements in genomic medicine to admixed individuals

Study: Sex matters when it comes to susceptibility to infections and other health conditions

Study finds higher levels of air pollutants in regions near oil and gas wells

Eating mushrooms may benefit a person's mental health, study reveals

Regulatory network impacting brain evolution found in “junk DNA,” says study

Study details metabolic processes employed by SARS-CoV-2 to attack lung tissue

Oral diuretic pill may potentially be repurposed to treat Alzheimer's in people with genetic risk

New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Researchers unravel impacts of protein BRD4 on how DNA folds

Mesenchymal stem cells with enhanced fracture healing abilities identified

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