Antisense News and Research

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Antisense is the non-coding strand in double-stranded DNA. The antisense strand serves as the template for mRNA synthesis.

The Influence of 'Silent' Mutations on Genetic Disorders

Genetic disorders -; like cystic fibrosis and Huntington's disease -; are considered incurable, with gene mutations occurring in essentially every cell of the body.

29 Aug 2024

Antisense Therapy Shows Promise Against Parkinson's

Parkinson's disease (PD), as well as many other neurodegenerative disorders, has shown a link between the abnormal aggregation of a protein called α-synuclein (aSyn) and neuronal death. These aggregates, known as Lewy bodies and Lewy neurites depending on their subcellular localization, can spread by continuously causing normal endogenous aSyn to misfold.

26 Jul 2024

Unlocking the Role of Antisense RNA as a Gene Expression Booster

The function of non-coding RNA in the cell has long been a mystery to researchers. Unlike coding RNA, non-coding RNA does not produce proteins – yet it exists in large quantities.

25 Jun 2024

Secarna and Orbit Discovery Partner to Develop Next-Generation Targeted ASO Therapeutics

Secarna Pharmaceuticals GmbH & Co. KG (Secarna), a leading independent European antisense drug discovery and development company, and Orbit Discovery Ltd. (Orbit), a leader in the discovery of therapeutic peptide hits, today announced that they have entered into a collaboration to discover and develop peptide-conjugated targeted antisense oligonucleotide (ASO) therapeutics.

3 Jun 2024

New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

Diseases that affect the brain and spinal cord can be particularly devastating, and finding new and more effective ways to treat these conditions is an important goal for researchers and clinicians alike.

23 May 2024

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

A significant research paper published in the journal Cell Metabolism by the team of Prof. LIU Qiang at the University of Science and Technology of China (USTC) reveals the critical role of glutamate tRNA fragments in brain aging and Alzheimer's disease.

14 May 2024

New Delivery System Opens the Door to Gene-Silencing Therapy

The next generation of medications, known as antisense oligonucleotides (ASOs), works by preventing the transmission of damaging genetic messages.

16 Apr 2024

Researchers Create Groundbreaking RNA and DNA Solutions to Shield Plants from Viral Attacks

Customized RNA or DNA molecules have been shown to effectively combat viral infections in plants, as demonstrated in a recent study conducted by Martin Luther University Halle-Wittenberg (MLU) and published in the International Journal of Molecular Sciences.

1 Mar 2024

Versatility of Rfamgen using Diverse RNA Families

The world’s first deep generative model for RNA design was created through a joint research project between Professors Hirohide Saito (Department of Life Science Frontiers, CiRA, Kyoto University) and Michiaki Hamada (Waseda University).

22 Jan 2024

'Orphan' Gene may Have Evolved to Give Seahorses Their Unique Brood Pouch

Teleost fish encompass a diverse group, among which seahorses display a unique morphology. The characteristic spines and brood pouch seen in seahorses feature distinctive epithelial cells-;called flame cone cells-;covered by a mucous cap.

25 Jul 2023

The Evolutionary Enigma: Unraveling the Origins of Seahorses' Flame Cone Cells

A brood pouch in male fish and bony plates gives seahorses their distinctive shape.

24 Jul 2023

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Proteins are large, complex molecules that play many critical roles in the body and are produced following the instructions encoded in DNA.

18 May 2023

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

Neuropathy is a type of chronic pain triggered by nerve injury or certain diseases. It affects millions of people worldwide, significantly deteriorating their quality of life.

5 May 2023

A Study on Gene Silencing Through a Recent Trial

Dr Catherine Mummery, a consultant neurologist at UCL Queen Square Institute of Neurology & the National Hospital for Neurology and Neurosurgery, has led a trial. The trial signifies for the first time that a “gene silencing” method has been taken in Alzheimer’s and dementia disease.

From University College London 27 Apr 2023

Antisense News and Research

The Influence of 'Silent' Mutations on Genetic Disorders

Antisense Therapy Shows Promise Against Parkinson's

Unlocking the Role of Antisense RNA as a Gene Expression Booster

Secarna and Orbit Discovery Partner to Develop Next-Generation Targeted ASO Therapeutics

New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

New Delivery System Opens the Door to Gene-Silencing Therapy

Researchers Create Groundbreaking RNA and DNA Solutions to Shield Plants from Viral Attacks

Versatility of Rfamgen using Diverse RNA Families

'Orphan' Gene may Have Evolved to Give Seahorses Their Unique Brood Pouch

The Evolutionary Enigma: Unraveling the Origins of Seahorses' Flame Cone Cells

Predictive Models to Determine the Structure, Stability, Flexibility and Biology of RNA-Targeted Drugs

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

A Study on Gene Silencing Through a Recent Trial

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

DNA drugs help restore the normal processing of protein-encoding RNA

Delaying paralysis in ALS by using designer DNA drug

New puzzle challenge taps into the intelligence of Eterna’s users to advance RNA therapeutics

New technique reveals how environmental changes affect the dynamic structures of RNAs in living cells

New computer model helps identify mutations that drive tumor growth

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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