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Study Finds Key Mechanism Behind Plasma Cell Migration for Lasting Immunity

Vaccine effectiveness relies on creating a strong antibody response that can be reactivated to fight future infections.

13 Mar 2025

Macrophages Use Bacterial Debris To Fine-Tune Immune Responses

Findings reveal macrophages' role in immune modulation through bacterial metabolites, paving the way for improved therapies for infections and inflammation.

6 Mar 2025

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

5 Mar 2025

Viking Skulls Show Evidence of Disease and Painful Conditions

Sweden's Viking Age population appears to have suffered from severe oral and maxillofacial disease, sinus and ear infections, osteoarthritis, and much more.

24 Feb 2025

Dysfunctional Memory B Cells Identified as Key Cancer Therapy Target

University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center scientists have discovered a novel subset of cancer-fighting immune cells that reside outside of their normal neighborhood – known as the tertiary lymphoid structure – where they become frustratingly dysfunctional when in close contact with tumors.

20 Feb 2025

New CRISPR Tool Reveals Key Lymphoma Genes

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

7 Feb 2025

Inflammasome Helps Block Malignancy in Blood Stem Cells

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity, according to a preclinical study by Weill Cornell Medicine investigators.

17 Jan 2025

New Approach Aims to Make CRISPR Therapy Safer and More Effective

CRISPR is a powerful gene-editing tool that holds enormous potential for treating genetic diseases by allowing scientists to cut, replace, or delete mutations in DNA.

16 Jan 2025

Unveiling Human Stem Cell Model with Functional Notochord

For the first time, the notochord a tissue in the developing embryo that serves as a navigation system, telling cells where to build the spine and nervous system (the trunk) has been included in human stem cell models created by researchers at the Francis Crick Institute.

19 Dec 2024

New Study Links Ancient Human Remains from Zlatý kůň and Ranis in Genetic Findings

After modern humans left Africa, they met and interbred with Neandertals, resulting in around two to three percent Neandertal DNA that can be found in the genomes of all people outside Africa today. However, little is known about the genetics of these first pioneers in Europe and the timing of the Neandertal admixture with non-Africans.

13 Dec 2024

The Mechanics Behind Crocodile Morphology: A Breakthrough in Evolutionary Biology

How do humans account for the variety of morphologies found in living things? Genetics is usually the first explanation that comes to mind, but it is not the only one.

12 Dec 2024

Unveiling the Epigenetic Landscape of Blood Cancers

In recent years, biomedical laboratory research has undergone tremendous change, to the extent that computers have frequently replaced test tubes.

27 Nov 2024

Researchers Provide Genetic Diagnosis for 30 Long-Term Undiagnosed Cases

An international team of researchers has provided a genetic diagnosis for 30 individuals whose condition was undiagnosed for years despite extensive clinical or genetic testing.

11 Nov 2024

New GIFT Method Outshines GWAS in Genetic Breakthrough

Genomic Informational Field Theory (GIFT) enhances genetic association detection, outperforming GWAS in mapping complex traits and subtle genetic interactions.

8 Nov 2024

AI and Bioinformatics Reveal Genes Linked to Rheumatoid Arthritis and Osteoporosis

Rheumatoid arthritis is a common disease affecting an estimated 17 million people worldwide. The disease is caused by immune cells attacking the joints and can result in pain, swelling, and damage to the cartilage and bone.

6 Nov 2024

A New Statistical Method to Mitigate AI Bias in Genetic Research

Researchers at the University of Wisconsin–Madison are cautioning that the growing use of artificial intelligence techniques in genetics and medicine may result in incorrect inferences regarding the relationship between genes and physical traits, such as risk factors for diseases like diabetes.

5 Nov 2024