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Study Reveals Role of Gut Microbes in Enhancing Children's Health

To address childhood malnutrition -; which affects 200 million children globally -; researchers at Washington University School of Medicine in St. Louis developed a therapeutic food that nourishes the collections of beneficial microbes that reside in the gut, and improves children's growth and other measures of their health.

25 Oct 2024

Mini-Gut Model Unlocks Secrets of COVID-19 Diarrhea

Researchers at Johns Hopkins Medicine claim to have identified multiple molecular pathways linked to diarrhea caused by COVID-19, offering possible therapeutic interventions utilizing human stem cells to create a sort of “mini intestine-in-a-dish.

7 Aug 2024

Neuregulin 3 Gene Variant Linked to Gabapentin Effectiveness in Chronic Pelvic Pain

Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows.

16 Jul 2024

New Cold-Sensing Protein Discovery Could Revolutionize Pain Management

The only available treatments for millions of people with chronic pain worldwide frequently involve the use of opioids, which pose the risk of addiction and overdose.

24 Jun 2024

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024

New Technology Enables Minimally-Invasive, High-Resolution Recording of Brain Activity

Sensors built with a new manufacturing approach are capable of recording activity deep within the brain from large populations of individual neurons–with a resolution of as few as one or two neurons–in humans as well as a range of animal models, according to a study published in the Jan. 17, 2024 issue of the journal Nature Communications.

18 Jan 2024

Novel Biosensors Uncover Brain Activity

Researchers have employed novel biosensors to uncover neuropeptide activity in the brain, introducing innovative tools for examining the release, function, and regulation of these vital signaling molecules in vivo.

17 Nov 2023

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

23 May 2023

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

Neuropathy is a type of chronic pain triggered by nerve injury or certain diseases. It affects millions of people worldwide, significantly deteriorating their quality of life.

5 May 2023

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

The protein PKMzeta has been strongly associated with long-term memory formation.

19 Apr 2023

Wearable microscopes produce real-time images of mouse spinal cord activity

The spinal cord acts as a messenger, carrying signals between the brain and body to regulate everything from breathing to movement.

23 Mar 2023

Long-term deep meditation may have a beneficial effect on gut microbiota, study suggests

Regular deep meditation, practised for several years, may help to regulate the gut microbiome and potentially lower the risks of physical and mental ill health, finds a small comparative study published in the open access journal General Psychiatry.

30 Jan 2023

New molecular profile of endometriosis to help improve therapeutic options

At Cedars-Sinai, a special and elaborate molecular profile of endometriosis has been engineered by investigators to help enhance therapeutic options for the millions of women suffering from the disease.

11 Jan 2023

Novel molecules alleviate pain, avoid sedating effect

According to new research headed by UC San Francisco scientists, a newly found group of molecules relieved pain in mice whilst preventing the sedating effect that limits the usage of opiates.

3 Oct 2022

Research outlines how stem cells become sensory interneurons

In a first-of-its-kind blueprint, scientists have shown how stem cells mature into sensory interneurons, which are responsible for feelings including touch, pain, and itching.

22 Jul 2022

Researchers focus to create a new class of molecules for curing biofilm infections

Chronic skin wounds are a rising global issue among the elderly, individuals with severe burns, and people with underlying medical diseases such as diabetes.

1 Apr 2022

Researchers identify the underlying molecular mechanism for development of chronic pain

One epigenetic factor as well as one organic anion transporter (OAT1), whose function in the nervous system was hitherto unknown, contribute to the development of chronic pain.

9 Mar 2022

Tropical sea anemone stings could hold key to new pain-relieving drugs

QUT PhD researcher Lauren Ashwood has studied sea anemones' venom makeup extensively, in particular, Telmatactis stephensoni a reef-based sea anemone that can grow from 8 to 10 cm.

8 Feb 2022

Loss of mitochondrial respiration alters mechanical properties of the cartilage

A group of researchers headed by Professor Dr Bent Brachvogel, Head of Experimental Neonatology at the Faculty of Medicine and University Hospital Cologne, have identified regulatory mechanisms of tissue organization which were earlier unknown.

8 Oct 2021