Gene Therapy News and Research

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Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery.

London Ranked Top City in Europe for Life Sciences

A newly released report has named London the #1 city in Europe and #3 globally for life sciences, behind Boston and New York, and ahead of Amsterdam, Munich, Paris, San Francisco, and Singapore.

18 Nov 2024

New Strategy Reinvigorates Exhausted T Cells to Fight Cancer

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

11 Nov 2024

Artificial Intelligence Designs Novel DNA Elements for Precise Gene Control

Using artificial intelligence, scientists at Yale University, the Broad Institute of MIT and Harvard, and The Jackson Laboratory have created thousands of novel DNA switches that can precisely regulate a gene's expression in many cell types.

24 Oct 2024

Magnetic Control of Brain Cells: A Step Forward in Neuromodulation

The introduction of magnetogenetics provides a noninvasive technique to modulate brain circuits, paving the way for innovative therapies in neuromodulation.

18 Oct 2024

Study Expands Potential of Retrons for DNA Editing

Within bacterial cells, specialized immune systems known as retrons fend off viral attacks. But that's not all they can do.

18 Sep 2024

Exploring Retrotransposon-Derived DNA Zip Codes in Myeloma Cell Internalization

A new editorial was published in Oncoscience (Volume 11) on July 13, 2024, entitled, "Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization."

12 Aug 2024

Scientists Develop AI-Powered Tool to Optimize Gene Delivery

Gene therapy could potentially cure genetic diseases but it remains a challenge to package and deliver new genes to specific cells safely and effectively. Existing methods of engineering one of the most commonly used gene-delivery vehicles, adeno-associated viruses (AAV), are often slow and inefficient.

9 Aug 2024

Noninvasive Ultrasound Method Enables Tracking of Gene Expression in Specific Brain Regions

The ability to alter or prevent the expression of faulty genes in the brain could be leveraged as a powerful therapeutic against neurodegenerative disease. However, the molecular underpinnings of the living brain are still largely inaccessible, hampering progress on such promising therapeutics.

9 Aug 2024

Innovative Nanosensing Method Promises Safer Gene Therapy with Improved AAV Vector Quality

Over the past few decades, there has been remarkable progress in genetic manipulation technologies, bringing us closer to the point where genes can be modified in vivo.

2 Aug 2024

New Gene Therapy Approach Improves Muscle Strength in DMD Mice

Indiana University School of Medicine researchers have made a significant breakthrough in developing a new gene therapy approach that restores full-length dystrophin protein, which could lead to new treatments for people with Duchenne muscular dystrophy (DMD).

29 Jul 2024

Developing DNA Test to Eliminate Inherited Blindness in English Shepherd Dogs

Researchers at Cambridge have discovered the genetic mutation that causes English Shepherd Dogs to suffer from progressive retinal atrophy, an irreversible form of blindness.

22 Jul 2024

TRPC5 Gene Alterations: A Key Player in Obesity and Postpartum Depression

Researchers at Baylor College of Medicine, the University of Cambridge and collaborating institutions have discovered that alterations in the human gene TRPC5 cause obesity and postpartum depression.

3 Jul 2024

Bridge RNA: The Revolutionary Tool in Genetic Recombination

In a leap forward for genetic engineering, a team of researchers from the Arc Institute have discovered the bridge recombinase mechanism, a precise and powerful tool to recombine and rearrange DNA in a programmable way.

27 Jun 2024

Tabulae Paralytica: Mapping Cellular Dynamics in Spinal Cord Injuries

Scientists at EPFL have achieved a significant research milestone in the field of spinal cord injuries-;mapping out the cellular and molecular dynamics of paralysis in unprecedented detail with their open-source project 'Tabulae Paralytica'.

20 Jun 2024

Engineered Enzyme Boosts Gene Editing Efficiency for Potential Cystic Fibrosis Treatment

Researchers at the Broad Institute of MIT and Harvard have enhanced a gene-editing technology, enabling it to efficiently insert or substitute entire genes in the genome of human cells.

11 Jun 2024

Efficient Gene Editing with Compact Cas12a Protein

Researchers have created an innovative version of a critical CRISPR gene-editing protein that has effective editing activity and is small enough to be bundled into a non-pathogenic virus capable of delivering it to targeted cells.

31 May 2024

Structural Insights into a Novel Gene-Editing Tool

Yutaro Shuto, Ryoya Nakagawa, and Osamu Nureki of the University of Tokyo conducted collaborative research to ascertain the spatial organization of different processes within a unique gene-editing instrument known as “prime editor.”

30 May 2024

Comprehensive Analysis of Gene-Isoform Variation Unlocks Secrets of Brain Development

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain.

24 May 2024

Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

16 May 2024

Bio-Techne Surpasses 10,000 Peer-Reviewed Publications Citing RNAscope Technology

Bio-Techne Corporation today announced that Advanced Cell Diagnostics (ACD), part of Bio-Techne's Spatial Biology Division, has surpassed 10,000 peer-reviewed publications referencing the use and application of RNAscope™ ISH technology.

From Bio-Techne 10 Apr 2024