Glutamine News and Research

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Glutamine is an amino acid used in nutrition therapy. It is also being studied for the treatment of diarrhea caused by radiation therapy to the pelvis.

Nutrient Deprivation Strategy Kills Breast Cancer Cells by Blocking Adaptive Pathways

Cancer cells have voracious appetites. And there are certain nutrients they can't live without. Scientists have long hoped they might stop tumors in their tracks by cutting off an essential part of cancer cells' diet. But these cells are crafty and often find a new way to get what they need. How? By reprogramming their metabolism and switching to backup food supplies.

29 Aug 2024

Metabolic Priming of CAR T Cells for Treatment of Solid Tumors

A promising therapy that treats blood cancers by harnessing the power of the immune system to target and destroy cancer cells could now treat solid tumors more efficiently.

3 Jul 2024

Unlocking the Spatial Dynamics of Amino Acid Metabolism in Tea Plants

Amino acids are vital for plant growth and significantly influence tea flavor and health benefits. Tea plants, particularly Camellia sinensis, exhibit unique amino acid profiles that contribute to their distinctive taste and nutritional value.

25 Jun 2024

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

A significant research paper published in the journal Cell Metabolism by the team of Prof. LIU Qiang at the University of Science and Technology of China (USTC) reveals the critical role of glutamate tRNA fragments in brain aging and Alzheimer's disease.

14 May 2024

Study Identifies Significant Changes in Peptides During Pyroglutamination

Peptides are biomolecules formed when two or more amino acids that perform key functions in the human organism, such as hormones, neurotransmitters, painkillers and antibiotics, bind together. For this reason, they are much studied and used by the pharmaceutical industry, for example.

2 Nov 2023

Researchers Target Pancreatic Cancer’s Metabolic Switch

In a recent study, a novel combination of treatments was discovered to effectively reduce the growth of pancreatic cancer in mice by inhibiting cancer cells from seeking fuel sources.

11 Oct 2023

New Synthetic Biology Approach Offers Promise for Treating Neurodegenerative Diseases

Researchers at the University of Cologne's CECAD Cluster of Excellence for Aging Research and the CEPLAS Cluster of Excellence for Plant Sciences have found a promising synthetic plant biology approach for the development of a therapy to treat human neurodegenerative diseases, especially Huntington's disease.

3 Oct 2023

Nutrient Tug-of-War Between Tumor and Immune Cells Could Be Targeted for Cancer Therapy

Scientists at St. Jude Children's Research Hospital found immune and tumor cells compete over glutamine, a major nutrient in their local environment, with significant implications for anti-cancer activity.

6 Jul 2023

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

6 Jul 2023

Targeting Cellular Respiration for the Treatment of Glioblastoma

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Targeting cellular respiration as a therapeutic strategy in glioblastoma."

22 May 2023

New insights into the mechanism underlying the immunomodulatory effects of polyphenols

PCB2DG, a polyphenol with anti-inflammatory properties, works by targeting and directly interacting with the major glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2), to inhibit the uptake of glutamine, an important amino acid found in the blood.

22 Feb 2023

Glutamine News and Research

Nutrient Deprivation Strategy Kills Breast Cancer Cells by Blocking Adaptive Pathways

Metabolic Priming of CAR T Cells for Treatment of Solid Tumors

Unlocking the Spatial Dynamics of Amino Acid Metabolism in Tea Plants

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

Study Identifies Significant Changes in Peptides During Pyroglutamination

Researchers Target Pancreatic Cancer’s Metabolic Switch

New Synthetic Biology Approach Offers Promise for Treating Neurodegenerative Diseases

Nutrient Tug-of-War Between Tumor and Immune Cells Could Be Targeted for Cancer Therapy

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Targeting Cellular Respiration for the Treatment of Glioblastoma

New insights into the mechanism underlying the immunomodulatory effects of polyphenols

The link between tandem repeats and development of Schizophrenia

Preventing protein-protein interactions with a new tool

ZDHHC18-mediated MDH2 palmitoylation upholds mitochondrial respiration and boosts ovarian cancer malignancy

Metabolic restoration could provide natural protection against HIV

Researchers upend the models of cancer metabolism

Nutritional supplement may reduce the risk of strokes caused by a rare genetic disorder

Study reveals the structure of heat shock proteins that could treat Huntington's disease

Study shows metabolic state of disease-causing parasite influences its resistance to drugs

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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