Hemoglobin News and Research

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Enhancing Laboratory Performance with Comprehensive HIL Monitoring

The release of the new version of ISO 15189 (2022), introduced increased focus on risk stratification and mitigation for patients and laboratory stakeholders as well as more emphasis on quality control to improve accuracy and validity of results. Interference caused by hemolysis, icterus and lipemia is responsible for many rejected results and incorrect diagnosis. It is therefore of the upmost importance to accurately capture the presence of interfering substances in samples before quantitative analysis is carried out.

29 Jul 2024

St. Jude Researchers Discover NLRC5's Role in Inflammatory Cell Death

The innate immune system is responsible for protecting the human body from threats that could cause disease or infection.

17 Jun 2024

LC-MS/MS analysis provides new insights into early childhood health and development

The impact of a hydrolyzed formula dietary intervention on β-cell autoimmunity development.

30 May 2024

Engineering Blood Vessels to Image Bioluminescence Deep Within the Brain

Researchers frequently tag cells with fluorescent proteins, which enable them to monitor tumor growth or quantify alterations in gene expression that transpire during cell differentiation.

13 May 2024

New Method Designs Proteins With Complex Shapes

A team of researchers has developed an innovative method to design complicated all-α proteins, characterized by their non-uniformly arranged α-helices as seen in hemoglobin.

5 Jan 2024

Novel Technique for High-Resolution Spectral Analysis of the Eye Fundus

Many ocular diseases involve changes in the structure and function of different regions of the back of the eye, also known as the "eye fundus."

18 Dec 2023

Brain Scans Reveal Touch Response in Infants

Scientists at Tokyo Metropolitan University have gauged the fluctuations in oxygenated hemoglobin levels in the brains of infants in response to tactile stimuli.

11 Dec 2023

Unveiling Epidermal Hemoglobin: A Breakthrough in Skin Research

Scientists have, for the first time, demonstrated the presence of hemoglobin—a protein primarily known for its role in binding with oxygen within red blood cells—in the epidermis, the outermost tissue layer of human skin.

20 Nov 2023

New Proof-of-Concept Model for Delivering Gene Editing Tools to Treat Blood Disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

28 Jul 2023

Scientists Develop Method to Create Artificial Allosteric Sites in Protein Complexes

According to a recently published research paper by a team of scientists, a groundbreaking approach has been developed to create artificial allosteric sites (where by binding an effector molecule, activity at the distal active site is regulated) in protein complexes.

7 Jul 2023

Computational Approach Could Uncover Transcriptional Regulatory Mechanisms and Causal Noncoding Variants

Less than two percent of the human genome codes for proteins, with the rest being noncoding and likely helping with gene regulation.

31 May 2023

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

5 May 2023

Sickle Cell Disease Cure? Prime Editing Offers Hope for Blood Disorder

At St Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard, researchers have shown how prime editing could help correct the mutation that results in sickle cell disease in a possibly curative method.

18 Apr 2023

Researchers provide an entirely new perspective on tissue oxygenation

Cardiovascular medicine, hematology and pulmonary medicine may soon have the first-ever therapies to correct poor tissue oxygenation, a key driver of disease in millions, including peripheral artery disease, sickle cell disease, heart failure, stroke, emphysema and many others.

2 Mar 2023

Prolonged longevity in mice with gene clusters

Numerous candidate genes that affect longevity have recently been found, according to research from the Interventions Testing Program, which is supported by the National Institute on Aging (NIA).

14 Oct 2022

Iron-sulfur cofactors are moved with the help of glutathione, experts reveal

The creation and movement of an essential class of molecules in human cells are now better understood according to a recent study.

8 Sep 2022

National DNA Day 2022: an interview with Professor Matthew Cobb

To celebrate National DNA Day 2022, we spoke to science communicator Professor Matthew Cobb.

From The University of Manchester 25 Apr 2022

Researchers use CRISPR gene editing tool to analyze globin gene switching

CRISPR gene editing—a form of “molecular scissors”—was used by UNSW researchers to investigate how deletions in one section of the genome might impact the expression of surrounding genes.

From The University of New South Wales (UNSW) 19 Apr 2022

Globins in the body help fight liver disease

Anti-fibrotic therapy is still a medical necessity in the treatment of chronic liver disease in humans. The anti-fibrotic activity of globin family members in hepatic stellate cells (HSCs), the principal cell type involved in liver fibrosis, was reported by a research group led by Professor Norifumi Kawada of Osaka Metropolitan University (OMU).

24 Mar 2022