Herpes Simplex Virus News and Research

RSS

New Study Uncovers How Viral Infections Trigger Pain, Identifies Potential Target for Relief

Findings indicate nociceptors detect viral nucleic acids, activating STING and TRPV1, highlighting new pain mechanisms in viral infections like HSV-1.

23 Oct 2024

New Discovery Reveals How MX Protein Traps HIV and Herpes Viruses

A group of researchers led by Xavier Saelens and Sven Eyckerman at the VIB-UGent Center for Medical Biotechnology discovered how a protein linked to the human immune system wards off HIV-1 and herpes simplex virus-1 by assembling structures in the cell that lure in these viruses and then trap them or even take them apart.

11 Oct 2024

Cryo-EM Study Sheds Light on HSV Drug Resistance Mechanisms Through Protein Movement

All organisms -; from fungi to mammals -; have the capacity to evolve and adapt to their environments. But viruses are master shapeshifters with an ability to mutate greater than any other organism. As a result, they can evade treatments or acquire resistance to once-effective antiviral medications.

28 Aug 2024

New Assay Fast-Tracks Virucidal Testing

An innovative technique that can quickly ascertain whether a virus is contagious or not has the potential to completely transform how humans respond to pandemics in the future.

24 Jul 2024

Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

16 May 2024

Research Reveals Conserved Neutralizing Epitope in Herpesvirus gB Protein

Human herpesviruses comprise the alpha, beta, and gamma subfamilies and are a widely prevalent group of DNA-enveloped viruses, capable of establishing lifelong latent infections in humans and causing various diseases.

27 Feb 2024

The Potential of Monoclonal Antibodies for Neonatal Herpes

The results of a recent study led by the Geisel School of Medicine and Thayer School of Engineering at Dartmouth, and published in Cell Reports Medicine, provide new information about the role that antibodies play in preventing herpes simplex virus (HSV) infections.

13 Feb 2024

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

Effective backup mechanism ensures efficient antimicrobial responses in humans

In the human body, virus particles are identified by pattern recognition receptors (PRRs) either within or on the cell surface. When a receptor is activated, a signaling cascade is initiated, which results in the production and release of signaling molecules like interferons and cytokines.

14 Mar 2023

Chemically attenuated live DNA virus vaccine prevents viral infection

Rutgers researchers have devised a new way to prevent viral infections: a live-attenuated, replication-defective DNA virus vaccine that utilizes the substance centanamycin to create an altered virus for vaccine development.

From Rutgers University 22 Nov 2022

Research highlights how cornea T cells may track and combat viral infections

According to a new study, the cornea creates a sensitive and restricted immune response to combat infections without causing visual damage.

30 May 2022

Study identifies protein complex that confers neuroprotection against HSV-1 infection

Recent research by scientists from the University of Illinois demonstrates a process that halts the herpes simplex virus 1 from inducing severe brain damage and death.

15 Oct 2021

Study details the role of PANoptosome in activating innate immune response

Immunologists discovered how immune sensors in infected cells organize and initiate an immune response to infections with living bacteria and viruses.

3 Sep 2021

Small synthetic molecules could one day cure or prevent COVID-19, herpes

In addition to antibodies and white blood cells, the immune system deploys peptides to fight viruses and other pathogens.

24 Aug 2021

Key protein regulates cells’ innate defense mechanisms

Scientists from the University of Illinois Chicago (UIC) have found that heparanase (HPSE) is an important regulator of innate defense mechanisms of cells.

17 Mar 2021

Researchers use new decoding method to identify novel proteins encoded by HSV-1

Comprehensive identification of viral proteins encoded by viral genes is required to understand the pathophysiology of viral infections.

8 Dec 2020

Genetically edited form of herpes simplex virus outperforms key vaccine candidate

A genetically edited form of a herpes simplex virus -- rewired to keep it from taking refuge in the nervous system and eluding an immune response -- has outperformed a leading vaccine candidate in a new study from the University of Cincinnati, Northwestern University and the University of Nebraska-Lincoln.

9 Nov 2020

Study shows immune cells contribute to brain infection

A new study shows how the immune system has a damaging effect on a severe brain condition, which is most commonly caused by the cold sore virus.

17 Sep 2020

STING protein activates a pathway that kills tumor-fighting immune cells

The immune protein STING has long been noted for helping protect against viruses and tumors by signaling a well-known immune molecule. Now, UT Southwestern scientists have revealed that STING also activates a separate pathway, one that directly kills tumor-fighting immune cells.

25 Aug 2020

Novel gene editing approach removes latent herpes simplex virus 1

Infectious disease researchers at Fred Hutchinson Cancer Research Center have used a gene editing approach to remove latent herpes simplex virus 1, or HSV-1, also known as oral herpes.

19 Aug 2020