High throughput screening News and Research

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High-throughput screening (HTS) allows scientists to test thousands of samples at once. These samples can be of a wide variety, and include, but are not limited to, amino acids, chemical compounds or cells.

High-throughput screening identifies potential drugs for low-grade serous ovarian cancer

In a recent study, researchers used high-throughput drug screening to identify potential therapeutic targets and novel treatments for low-grade serous ovarian cancer (LGSOC), offering hope for more effective and personalized therapies.

26 Sep 2024

Surface Plasmon Resonance Sensors: Transforming Drug Development and Clinical Diagnostics

The latest developments in SPR-based biosensors and their applications in drug discovery.

15 Jul 2024

DeepEvo: Revolutionizing Protein Engineering with Artificial Intelligence

Engineering proteins for desirable traits has been the holy grail of modern biotechnology.

1 Jul 2024

CRISPR Screening Reveals Peptide in Human RNA Regulating Inflammation

UC Santa Cruz researchers have discovered a peptide in human RNA that regulates inflammation and may provide a new path for treating diseases such as arthritis and lupus.

27 May 2024

SCIEX Expands High-Throughput Screening Solutions With Echo® MS+ System

SCIEX, a global leader in life science analytical technologies, launches the Echo® MS+ system at SLAS 2024.

From SCIEX 6 Feb 2024

Bacteria's Immune System Enhances the Effect of Antibiotics Against Cholera Pathogen

Bacteria have an immune system that protects them against viruses known as bacteriophages. A research team from the Universities of Tübingen and Würzburg has now shown how this immune system enhances the effect of specific antibiotics against the cholera pathogen Vibrio cholerae.

22 Jan 2024

EPFL Scientists Develop Platform for Orally Available Cyclic Peptide Drugs

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy.

29 Dec 2023

Yeast-Based Method Could Accelerate Discovery of Plant-Based Medicinal Compounds

Cornell researchers have harnessed the power of baker's yeast to create a cost-effective and highly efficient approach for unraveling how plants synthesize medicinal compounds, and used the new method to identify key enzymes in a kratom tree.

19 Oct 2023

Deep Learning Model Accurately Predicts RNA-Targeting CRISPR Activity

According to new research published in Nature Biotechnology, artificial intelligence can predict on- and off-target behavior of CRISPR tools that target RNA rather than DNA.

5 Jul 2023

High-Throughput Screening of Existing Drugs to Fight Multiple Myeloma More Effectively

Multiple myeloma is a rare blood cancer caused by the uncontrolled multiplication of abnormal plasma cells.

28 Apr 2023

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

The April 2023 issue of SLAS Discovery contains six full-length articles and one mini-review covering high-throughput screening (HTS) for protease-inhibiting drugs, high-content phenotypic screening and other life sciences research.

28 Apr 2023

A Nanoplasmonics Approach to Observe Real-Time Production of Cell Secretions

Researchers at the University of Geneva have developed a novel optical imaging approach that provides a four-dimensional view of cell secretions in real-time, including their spatial and temporal dynamics.

13 Apr 2023

FDA-approved compound promotes photoreceptor survival in lab models of inherited retinal ciliopathy

A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.

30 Mar 2023

MoBIE: New user-friendly, freely available tool for sharing large imaging data sets

High-resolution microscopy techniques, for example electron microscopy or super-resolution microscopy, produce huge amounts of data.

24 Feb 2023

A high-throughput drug discovery assay for the endoplasmic reticulum aminopeptidase 1

The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.

31 Jan 2023

Drug discovery method facilitates promising treatment approaches for metabolic diseases

The body’s chemical processes known as “metabolism” produce the raw materials needed for development and general health.

17 Oct 2022

Orbit Discovery awarded Innovate UK grant to expand high throughput cell-based functional screening platform capabilities in peptide drug discovery

Orbit Discovery Ltd., (“Orbit”) a privately held biopharmaceutical company focused on discovering candidate peptide therapeutics harnessing proprietary affinity and cell-based functional screening platforms, has been awarded a Smart grant by Innovate UK, the UK’s innovation agency.

From Orbit Discovery 14 Jun 2022

bit.bio launches Huntington’s disease human cell model

First neurodegenerative disease model launched from bit.bio's new ioDisease Model portfolio.

From bit.bio 10 May 2022

Dotphoton and Hamamatsu Photonics are partnering to provide the ultimate raw image compression and address the ever-growing biomedical image data volume

Dotphoton, an industry-leading raw image compression company and Hamamatsu Photonics, a world leader in optical systems and photonics manufacturing, are pleased to announce their new partnership.

From Hamamatsu Photonics Europe 26 Apr 2022

New 'disease-in-a-dish' system developed to study oculocutaneous albinism

Researchers at the National Eye Institute have developed the first patient-derived stem cell model for studying eye conditions related to oculocutaneous albinism (OCA).

12 Jan 2022