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Synthetic Microbiome Treatment Prevents C. difficile Infection in Mice

A synthetic microbiome therapy, tested in mice, protects against severe symptoms of a gut infection that is notoriously difficult-to-treat and potentially life threatening in humans, according to a team of researchers at Penn State.

4 Mar 2025

Rare Gene Variants Increase Type 2 Diabetes Prevalence in Asian Indian Families

A new study published in Communications Medicine, a Nature publication, details the discovery of rare gene variants that increase the prevalence of Type 2 diabetes in multiple generations of Asian Indian people.

27 Feb 2025

Immunotherapy Breakthrough Targets Jumbled Proteins in Glioma

Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue.

20 Feb 2025

Groundbreaking Gene Switch Offers New Hope for Metabolic Disease Treatments

ETH researchers have developed a new gene switch that can be activated using a commercially available nitroglycerine patch applied to the skin.

17 Feb 2025

Single-Cell Analysis Reveals Critical Kidney Cell Types Involved in Disease

Researchers at the University of Pennsylvania's Perelman School of Medicine have published a new study in the journal Science that suggests over 1,000 genes could be potential targets for kidney disease treatment.

12 Feb 2025

New Research Identifies Brain Cells Linked to Alcohol-Induced Insomnia

Alcohol use disorder, which affects over 10% of Americans, can lead to persistent and serious insomnia.

8 Feb 2025

Gut Microbes May Explain Link Between Sugar-Sweetened Beverages and Diabetes

It is well known that consuming sugary drinks increases the risk of diabetes, but the mechanism behind this relationship is unclear.

3 Feb 2025

New Numbering System Advances Adhesion GPCR Research

Adhesion GPCRs are a group of cell-surface sensors associated with many body functions and diseases. However, they are not yet sufficiently understood to be exploited for therapies.

29 Jan 2025

Researchers Discover Key Factor Behind Disease Resistance in Gene Carriers

New work by Columbia researchers has turned a textbook principle of genetics on its head and revealed why some people who carry disease-causing genes experience no symptoms.

3 Jan 2025

Cleveland Clinic Study Reveals Link Between Kidney Microbiome and Kidney Stones

Cleveland Clinic researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal.

12 Dec 2024

Genetic Signatures Driving Early Type 2 Diabetes in South Asians Revealed

A genetic predisposition to having lower insulin production and less healthy fat distribution are major causes of early-onset type 2 diabetes in British Asian people.

28 Nov 2024

TRISCO Reveals 3D RNA Structures at Cellular Resolution

A novel microscopy technique created by researchers at the Karolinska Institutet and Karolinska University Hospital allows for in-depth, three-dimensional (3D) RNA analysis at the cellular level in complete, undamaged mouse brains.

22 Nov 2024

Hepatitis E Virus Impairs Neuronal Cells, Reducing Neurite Length

For the first time, scientists can examine the effects of hepatitis E viruses on nerve cells using a novel cell model.

19 Nov 2024

Mouse Aging Proteomic Atlas Provides Insight into Age-Related Protein Shifts

With the worldwide population aging at an unprecedented rate, the prevention of age-related diseases has become a prominent issue.

18 Nov 2024

Comprehensive Proteomic Atlas of Aging in Mice

Preventing age-related illnesses has become a major concern as the global population ages at a never-before-seen rate.

15 Nov 2024

Caterpillar Fungus Compound Blocks Cancer Growth Signals Within 30 Minutes

Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for cell proliferation and survival.

15 Nov 2024

CRISPR Reveals Hidden Functions of Noncoding RNA

Genes contain instructions for protein production, with the central dogma of biology stating that this information flows from DNA to RNA to proteins.

8 Nov 2024

Unveiling the Protective Role of KLF6 in Diabetic Kidney Disease

Research by Stony Brook Medicine nephrology specialists may help prevent or reduce diabetic kidney disease progression by targeting cellular signaling between kidney cells and inducing a specific gene.

11 Oct 2024

A New Understanding of Chromatin Regulation and its Implications

Human survival is dependent upon an extraordinarily intricate dance that takes place inside every cell and every nucleus. DNA is continually being wrapped and unwrapped by proteins, and even small mistakes might result in cancer.

3 Oct 2024

Macrophage-Specific MAFB Deficiency Leads to Poor Prognosis in Acute Kidney Injury

Acute kidney injury (AKI) is associated with a poor prognosis, and no effective treatment has been established to date. Understanding the mechanisms that prevent the progression of AKI is crucial. In AKI, immune cells known as macrophages produce lipid mediators (LMs), which are lipids with significant physiological activity and play a pivotal role in promoting and suppressing inflammation. Thus, elucidating their function is of paramount importance.

30 Sep 2024