Kinase News and Research

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Caterpillar Fungus Compound Blocks Cancer Growth Signals Within 30 Minutes

Cordycepin, derived from fungi, shows promise in cancer therapy by inhibiting growth factor signaling pathways critical for cell proliferation and survival.

15 Nov 2024

Researchers Develop Fluorescent Biosensor to Study PKC Activity

Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival.

14 Oct 2024

Unveiling the Protective Role of KLF6 in Diabetic Kidney Disease

Research by Stony Brook Medicine nephrology specialists may help prevent or reduce diabetic kidney disease progression by targeting cellular signaling between kidney cells and inducing a specific gene.

11 Oct 2024

New Method for Identifying Kinase Inhibitors for Cancer Therapy

The most difficult subtype of breast cancer to treat is triple-negative breast cancer (TNBC). Over 20,000 cases of TNBC are reported each year in the United States alone.

10 Oct 2024

Scientists Uncover Secrets of Circadian Rhythm Control

Scientists from Duke-NUS Medical School and the University of California, Santa Cruz, have discovered the secret to regulating our internal clock.

8 Oct 2024

Motor And Extracellular Matrix Proteins Play A Critical Role In Cleft Palate Formation

The study reveals 44 differentially expressed proteins in cleft palate models, shedding light on molecular mechanisms and potential prenatal diagnostic markers.

30 Sep 2024

High-throughput screening identifies potential drugs for low-grade serous ovarian cancer

In a recent study, researchers used high-throughput drug screening to identify potential therapeutic targets and novel treatments for low-grade serous ovarian cancer (LGSOC), offering hope for more effective and personalized therapies.

26 Sep 2024

Harnessing the Power of Beneficial Bacteria to Fight Enterobacteriaceae

Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time. Gram-negative bacteria such as Enterobacteriaceae are a common cause of these infections and have few treatment options. Fecal microbiota transplants have shown promise to curb some of these infections, but their composition varies between batches and they aren't always successful.

23 Sep 2024

PKN Inhibition Reduces Cardiac Fibrosis and Improves Heart Function

The number of people suffering from heart failure is rising quickly as society ages. Heart failure progression is linked to fibrosis, or the overgrowth of fibrotic tissue in the heart.

16 Sep 2024

Breakthrough Nanoparticle Therapy Boosts Immune Response Against Aggressive Pancreatic Cancer

Innovative use of lipid nanoparticles to deliver immune agonists shows promise in activating anti-tumor immunity in pancreatic ductal adenocarcinoma models.

9 Sep 2024

RYBREVANT Receives EC Nod for Advanced Lung Cancer Treatment

Janssen-Cilag International NV, a Johnson & Johnson company, today announced that the European Commission (EC) has approved a Type II extension of indication for RYBREVANT®▼ (amivantamab) in combination with chemotherapy (carboplatin and pemetrexed), for the treatment of adults with advanced non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) Exon 19 deletions (ex19del) or Exon 21 L858R substitution (L858R) mutations, after failure of prior therapy including an EGFR tyrosine kinase inhibitor (TKI).

30 Aug 2024

The Molecular Process That Causes MS and Autoimmune Diseases

A human immune system suppressor known as “regulatory T cells” was first identified more than 20 years ago by a research team working in the lab of Yale researcher David Hafler, who was at Harvard at the time.

29 Aug 2024

Novel Technique to Study Ubiquitination

Once human proteins are synthesized, they go through some chemical changes. These adjustments control their stability, functionality, and structure.

13 Aug 2024

Emerging Treatments and Drug Repositioning for NAFLD and NASH

The current research on drug candidates and molecular targets being clinically tested for the treatment of non-alcoholic steatohepatitis (NASH) and NAFLD.

9 Aug 2024

New Findings Shed Light on ATM Activation in DNA Repair

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

9 Aug 2024

The Importance of Antioxidant Therapy in Preventing Parkinson's Disease

The neurodegenerative condition known as Parkinson's disease is caused by the death of neurons that generate dopamine, a neurotransmitter essential for both motor control and cognitive function.

6 Aug 2024

Researchers Uncover Unique Protective Mechanism in Pancreatic Cells

Researchers from the University of Cologne have revealed a mechanism protecting pancreatic β-cells, which are crucial for insulin production from inflammatory cell death. The study investigated the role of receptor-interacting protein kinase 1 (RIPK1) in regulating β-cell survival.

1 Aug 2024